Desalting Spin Columns

MtoZ Biolabs Desalting Spin Columns: Fast and Efficient Centrifugal Desalting of Peptide and Protein Samples for LC-MS/MS Analysis in Minutes

In LC-MS/MS sample preparation, rapid removal of salts, detergents, and reducing agents from peptide digests or purified proteins is essential. The Desalting Spin Columns from MtoZ Biolabs are packed with high-performance size-exclusion chromatography media and enable desalting and buffer exchange of small-volume samples (typically 5-100 µL) within 5-15 minutes through a simple centrifugation workflow. The approach provides high recovery and minimal operational complexity and is a standard step for preparing samples prior to LC-MS/MS injection in proteomics workflows.

Advantages

Ultra-Fast Processing

With the MtoZ Biolabs Desalting Spin Columns, desalting is completed within a single or several short centrifugation steps, saving hours to days compared with traditional dialysis or precipitation methods and improving experimental efficiency.

Excellent Recovery

Optimized hydrophilic inert media surfaces and column formats minimize non-specific adsorption losses, particularly for low-abundance peptide samples, supporting high recovery.

Superior Cleanup Performance

Common LC-MS/MS interfering substances such as Triton X-100, urea, DTT, and salts are efficiently removed, improving chromatographic peak shape and enhancing mass spectrometric signal quality.

Simple Operation Without Specialized Equipment

Only a standard laboratory microcentrifuge is required, and samples can be loaded, centrifuged, and collected following standardized steps without the need for additional devices or specialized training.

Technical Support

Protocol Downloads

MtoZ Biolabs provides comprehensive experimental protocols and product manuals to help ensure smooth and reproducible workflows. For access to specific documents or detailed instructions, please contact our support team.

Customized Service Support

Our experienced scientists offer tailored technical assistance and customized solutions based on your specific research goals, helping you achieve optimal experimental outcomes.

FAQ and Expert Assistance

We provide responsive and professional technical support to address your questions efficiently. Our experts are ready to help you identify and resolve experimental challenges quickly and accurately.