MtoZ Biolabs’ Acetonitrile, LC-MS Grade delivers exceptional purity and consistent performance, providing a reliable mobile-phase foundation for high-sensitivity LC-MS analyses.
Product Overview
In liquid chromatography-mass spectrometry (LC-MS) analyses, the purity of the mobile-phase solvent directly determines background noise levels, chromatographic peak shape, and the sensitivity and accuracy of mass spectrometric detection. When conventional or low-purity acetonitrile is used, the following issues commonly arise:
1. High Background Noise and Interfering Peaks
UV-absorbing impurities, organic residues, or trace metal ions present in impure solvents can generate persistent chemical background noise and difficult-to-interpret ghost peaks in mass spectra. These interferences severely compromise the detection and accurate quantification of target analytes, particularly low-abundance peptides or metabolites in LC-MS workflows.
2. System Contamination and Component Degradation
Non-volatile residues in low-quality solvents can gradually accumulate within the LC flow path, injection valves, chromatographic columns, and the MS ion source. This buildup may lead to increased backpressure, peak tailing, and ion source contamination, ultimately increasing instrument maintenance frequency and operational costs.
3. Batch-to-Batch Variability Affecting Reproducibility
Fluctuations in solvent quality can cause unstable chromatographic retention times, making cross-batch and inter-laboratory data comparison more challenging. Such variability undermines reproducibility and compromises the reliability of long-term proteomics and metabolomics studies conducted with LC-MS systems.
Advantages
✅ Ultra-High Purity Optimized for Mass Spectrometry
Acetonitrile, LC-MS Grade from MtoZ Biolabs is produced using advanced purification technologies and stringent multi-level quality control to ensure exceptionally low UV absorbance background, minimal non-volatile residues, and ultra-low metal ion content. This ultra-high purity effectively minimizes MS background noise and eliminates interfering peaks, providing a clean analytical environment for high-sensitivity proteomics and metabolomics research.
✅ Ensures Superior Chromatographic Performance
When paired with optimized aqueous phases and appropriate additives, this LC-MS grade acetonitrile enables sharp, symmetrical chromatographic peak shapes and highly reproducible retention times. This performance significantly improves separation resolution and data reliability for complex biological samples, forming the foundation for high-quality LC-MS results.
✅ Protects Instruments and Reduces Operating Costs
Its low corrosivity and low-residue characteristics help extend the service life of critical components such as chromatographic columns, pump seals, and MS ion sources. By reducing solvent-related contamination, it minimizes system downtime and maintenance frequency, ultimately lowering long-term instrument operating and maintenance costs.
✅ Outstanding Batch-to-Batch Consistency
Each production batch undergoes rigorous quality validation to ensure consistent key physicochemical parameters, including purity, water content, and absorbance. This high level of consistency provides a stable experimental foundation, ensuring data comparability and reproducibility in long-term research projects.
✅ Broad Compatibility and Flexible Packaging Options
This product is compatible with all LC-MS platforms, from conventional HPLC to UHPLC and nano-LC systems, and is one of the most essential organic modifiers for reversed-phase chromatography. Multiple packaging sizes, ranging from 100 mL to 4 L, are available to support diverse needs from method development to high-throughput analytical workflows.
Technical Support
1. Protocol Downloads
MtoZ Biolabs provides comprehensive experimental protocols and product manuals to help ensure smooth and reproducible workflows. For access to specific documents or detailed instructions, please contact our support team.
2. Customized Service Support
Our experienced scientists offer tailored technical assistance and customized solutions based on your specific research goals, helping you achieve optimal experimental outcomes.
3. FAQ and Expert Assistance
We provide responsive and professional technical support to address your questions efficiently. Our experts are ready to help you identify and resolve experimental challenges quickly and accurately.
