MtoZ Biolabs’ 200 µL Pipette Tips are high-performance, low-binding tips specifically engineered for fully automated protein sample preparation workflows, ensuring accurate low-volume liquid handling while preserving sample integrity.
Product Overview
When performing high-throughput, automated protein sample preparation, the reliability of each liquid-handling step is critical. However, conventional pipette tips often introduce several challenges in automated proteomics workflows:
1. Sample Adsorption-Induced Loss and Variability
Rough inner surfaces or inappropriate surface hydrophobicity in standard tips can lead to irreversible adsorption of trace-level proteins, peptides, or nucleic acids. This results in sample loss and inaccurate concentration measurements, particularly compromising detection sensitivity and quantitative accuracy for low-abundance targets.
2. Contamination From Chemical Leachables
During manufacturing, some pipette tips may introduce plasticizers, lubricants, or oligomeric residues. When exposed to organic solvents such as acetonitrile or methanol, or to detergents commonly used in proteomics workflows, these substances can leach out and appear as background ions in mass spectrometry analyses, interfering with analyte identification and quantification.
3. Poor Solvent Compatibility Affecting Performance
In automated workflows that routinely involve solvents such as acetonitrile, DMSO, or TFA, conventional tips may deform, soften, or even partially dissolve. Such material instability can compromise volumetric accuracy and generate particulates that clog liquid-handling channels, potentially leading to workflow interruptions.
4. Inconsistent Batch-to-Batch Performance
Variations in dimensional tolerances, elasticity, or surface properties between production batches can directly affect aspiration and dispensing accuracy on automated workstations. This variability undermines reproducibility and makes it difficult to establish standardized and scalable workflows.
Advantages
✅ Ultra-Low Binding for Maximum Sample Recovery
MtoZ Biolabs’ 200 µL Pipette Tips utilize a proprietary surface hydrophilization treatment to create an ultra-smooth, low-binding inner surface that significantly reduces nonspecific adsorption of biomolecules. Performance testing demonstrates adsorption losses for model proteins and peptides below industry benchmarks, ensuring quantitative transfer and high recovery of valuable samples.
✅ High-Purity Materials With No Background Contamination
Manufactured from high-quality medical-grade polypropylene under tightly controlled production conditions, the material is free of plasticizers, heavy metal ions, and RNase/DNase contamination. Even after prolonged exposure to high-percentage organic solvents, no detectable leachables are observed, ensuring clean and reliable mass spectrometry data.
✅ Outstanding Chemical and Physical Stability
The tips exhibit excellent resistance to solvents commonly used in proteomics workflows, including acetonitrile, methanol, isopropanol, acids, and mild detergents. Structural integrity and mechanical strength are maintained throughout extended automated operation, ensuring long-term reliability and liquid-handling accuracy.
✅ Precision Manufacturing for Automation Compatibility
Each tip is produced using high-precision molding and subjected to automated optical inspection. Tight dimensional tolerances meet the requirements of mainstream automated liquid-handling platforms, enabling smooth loading and unloading, accurate positioning, and reliable volumetric transfer in high-throughput workflows.
Technical Support
1. Protocol Downloads
MtoZ Biolabs provides comprehensive experimental protocols and product manuals to help ensure smooth and reproducible workflows. For access to specific documents or detailed instructions, please contact our support team.
2. Customized Service Support
Our experienced scientists offer tailored technical assistance and customized solutions based on your specific research goals, helping you achieve optimal experimental outcomes.
3. FAQ and Expert Assistance
We provide responsive and professional technical support to address your questions efficiently. Our experts are ready to help you identify and resolve experimental challenges quickly and accurately.
