The LTQ ESI Positive Ion Calibration Solution from MtoZ Biolabs is a ready-to-use, high-purity standard solution specifically designed to deliver accurate and reliable positive ion mode mass calibration for Thermo Scientific ion trap and Orbitrap mass spectrometers.
Product Overview
Regular and accurate mass calibration of Thermo Scientific ion trap mass spectrometers (such as the LTQ series) and Orbitrap high-resolution platforms is a critical step for maintaining stable instrument performance and ensuring reliable data quality. However, the use of non-dedicated or self-prepared calibration solutions often presents several challenges:
1. Complex Preparation and High Risk of Error
Users must precisely weigh and mix multiple reference compounds, making the preparation process time-consuming and prone to systematic errors caused by inaccurate weighing, solvent impurities, or operational variability, ultimately compromising calibration accuracy and reproducibility.
2. Inconsistent Calibration Quality
Non-standardized compositions or concentrations can result in weak calibration signals, incomplete mass coverage, or unstable MS responses, making it difficult to achieve optimal mass axis fitting.
3. Insufficient Purity Leading to Background Interference
Impurities originating from reagents or containers may generate interfering peaks or elevated background signals during calibration, affecting accurate peak assignment and integration, and potentially contaminating the ion source.
4. Inconvenient Handling and Storage
Some calibration standards are not supplied in ready-to-use formats and require frequent preparation and aliquoting, increasing operational complexity and contamination risk. Improper storage conditions may also lead to degradation or loss of performance.
Advantages
✅ Ready-to-Use, Standardized Calibration Solution
The LTQ ESI Positive Ion Calibration Solution from MtoZ Biolabs is supplied as a ready-to-use liquid formulation containing precisely defined concentrations of caffeine, MRFA (methionine-arginine-phenylalanine-alanine tetrapeptide), and Ultramark 1621 (a fluorinated phosphazene mixture). These highly ionizable compounds are dissolved in an optimized solvent system composed of acetonitrile, methanol, and acetic acid. The solution can be directly introduced via the ESI needle or syringe pump without any preparation steps, eliminating handling errors and ensuring consistent and reproducible calibration results.
✅ Carefully Selected Components for Comprehensive Mass Coverage
The optimized mixture generates a series of strong and stable calibration peaks across a wide mass range, spanning from low-molecular-weight compounds to high-mass polymer cluster ions. This comprehensive coverage supports accurate mass axis calibration for LTQ, Orbitrap, and related mass analyzers across typical application ranges.
✅ High-Purity Manufacturing and Stable Packaging
Manufactured in an ISO 9001-certified facility, each production batch undergoes stringent quality control to ensure exceptional purity and performance. The solution is packaged in high-quality, non-leaching PTFE (polytetrafluoroethylene) bottles to prevent leakage, adsorption, and contamination, ensuring long-term stability during storage and transportation.
✅ Broad Compatibility with Thermo Scientific MS Platforms
Optimized for positive ion mode operation on Thermo Scientific mass spectrometers, this calibration solution is compatible with a wide range of instruments, including the LTQ series, LTQ Velos series, LTQ Orbitrap series, LXQ, LCQ FLEET, and Exactive systems. It is an ideal standardized tool for routine performance verification, method validation, and instrument condition monitoring.
Technical Support
1. Protocol Downloads
MtoZ Biolabs provides comprehensive experimental protocols and product manuals to help ensure smooth and reproducible workflows. For access to specific documents or detailed instructions, please contact our support team.
2. Customized Service Support
Our experienced scientists offer tailored technical assistance and customized solutions based on your specific research goals, helping you achieve optimal experimental outcomes.
3. FAQ and Expert Assistance
We provide responsive and professional technical support to address your questions efficiently. Our experts are ready to help you identify and resolve experimental challenges quickly and accurately.
