Automated Protein Sample Preparation Systems

Efficient, Standardized Automation Solutions, Reliable and Reproducible Workflows for High-Throughput Proteomics and Standardized Sample Preparation.

In mass spectrometry-based proteomics, biomarker discovery, and large-scale clinical sample analysis, manual protein extraction, enzymatic digestion, labeling, and cleanup are time-consuming, labor-intensive, and highly susceptible to operator-dependent variability. These factors can significantly compromise data reproducibility and cross-study comparability.

The Fully Automated Protein Sample Preparation Workstation from MtoZ Biolabs integrates precise liquid handling, temperature control, incubation, and online purification into a single, unified platform. Through preconfigured or fully programmable standardized protocols, this system enables end-to-end automation, from cell or tissue lysis to MS-ready peptide samples, ensuring consistent and traceable sample processing. Designed to support large-cohort studies, multicenter collaborative projects, and laboratories with limited experience in proteomic sample preparation, the MtoZ Biolabs Fully Automated Protein Sample Preparation Workstation dramatically improves throughput while minimizing human error. Enforcing workflow consistency and standardization, it provides a robust foundation for generating high-quality, reproducible, and comparable proteomics data across experiments and time points.

Products

1. Integrated Instrument Platform

The MtoZ Biolabs Fully Automated Protein Sample Preparation Workstation is built as an integrated, modular platform equipped with a high-precision liquid handling system supporting volumes from nanoliters to milliliters. It incorporates multifunctional temperature control modules with a wide operating range (4 °C to 99 °C), an orbital shaking and incubation unit, and built-in online solid-phase extraction (SPE) or filtration capabilities.

Through an intuitive graphical software interface, users can easily create, modify, or deploy standardized workflows tailored to different sample types, such as cells, tissues, or plasma, and to diverse downstream proteomics applications, including label-free quantification, TMT labeling, and phosphopeptide enrichment. This design enables fully automated, end-to-end processing with a true “sample in, peptides out” workflow, delivered by the MtoZ Biolabs Fully Automated Protein Sample Preparation Workstation.

2. Compatible Consumables

MtoZ Biolabs compatible consumables are specifically designed for seamless integration with the automated workstation and are supplied in ready-to-use formats to ensure ease of operation and workflow consistency. The consumables portfolio includes:

(1) Preloaded Deep-Well Reagent Plates

containing lysis buffers, reduction and alkylation reagents, digestion buffers, and trypsin, allowing direct installation without manual reagent preparation and minimizing formulation-related variability.

(2) Automated Purification Plates or Cartridges

for online cleanup steps such as desalting, peptide cleanup, and phosphopeptide enrichment, delivering improved recovery and reproducibility.

(3) Standardized Sample Plates and Pipette Tips

precisely calibrated to ensure pipetting accuracy, system compatibility, and reliable long-term performance across automated workflows.

Advantages

1. High Throughput and Exceptional Efficiency

The MtoZ Biolabs Fully Automated Protein Sample Preparation Workstation supports parallel processing of up to 96 samples in a single run, compressing manual workflows that traditionally take several days into just a few hours. This dramatic gain in efficiency significantly increases research output and accelerates project turnaround timelines.

2. Substantially Reduced Human Error and Lower Technical Barriers

By eliminating manual pipetting, timing, and temperature-control steps, the MtoZ Biolabs Fully Automated Protein Sample Preparation Workstation minimizes operator-dependent variability. Even users without extensive experience in proteomic sample preparation can reliably generate stable, reproducible results.

3. Outstanding Workflow Standardization andReproducibility

Predefined, standardized protocols ensure highly consistent processing conditions within the same project, across different batches, and even between laboratories. This level of standardization delivered by MtoZ Biolabs greatly enhances data comparability, reliability, and scientific confidence.

4. Flexible Programmability and Broad Workflow Compatibility

The open and programmable software environment of the MtoZ Biolabs Fully Automated Protein Sample Preparation Workstation allows users to customize or optimize workflow steps based on specific experimental needs. This flexibility ensures seamless compatibility with a wide range of commonly used proteomics sample preparation strategies.

5. Comprehensive Traceability and Quality Control Documentation

The system automatically records critical information for each sample, including processing steps, reagent lot numbers, and operation timestamps. This complete audit trail provided by MtoZ Biolabs supports data quality assessment, workflow traceability, and compliance with regulatory or quality management requirements.

Technical Support

1. Protocol Downloads

MtoZ Biolabs provides comprehensive experimental protocols and product manuals to help ensure smooth and reproducible workflows. For access to specific documents or detailed instructions, please contact our support team.

2. Customized Service Support

Our experienced scientists offer tailored technical assistance and customized solutions based on your specific research goals, helping you achieve optimal experimental outcomes.

3. FAQ and Expert Assistance

We provide responsive and professional technical support to address your questions efficiently. Our experts are ready to help you identify and resolve experimental challenges quickly and accurately.