Glioblastoma Exosome Research Service
- Isolated Exosomes: ≥200 μg total protein or ≥100 μL in PBS
- Plasma/Serum: ≥2 mL per sample
- Cerebrospinal Fluid (CSF): ≥300 μL per sample
- Cell Culture Supernatants: ≥5 mL per sample
- Other Body Fluids: Please inquire for specific requirements
Glioblastoma (GBM), the most aggressive form of primary brain tumor in adults, is characterized by rapid proliferation, diffuse infiltration, and strong resistance to standard therapies. Despite advances in surgery, radiation, and chemotherapy, the prognosis for GBM remains poor. As a result, there is a critical need to identify novel biomarkers and therapeutic targets that reflect the biological complexity of GBM. Exosomes, nano-sized extracellular vesicles secreted by all cell types, including tumor cells, have emerged as central mediators of intercellular communication in the GBM tumor microenvironment. They carry a diverse cargo of proteins, lipids, DNA, and various RNA species (mRNA, miRNA, lncRNA), playing essential roles in tumor growth, angiogenesis, immune suppression, and treatment resistance. Exosomes derived from glioblastoma cells can cross the blood–brain barrier, making them ideal candidates for non-invasive liquid biopsy and real-time disease monitoring.
Figure 1. The Roles of Exosomes in Glioma's Development
Given the heterogeneity and invasiveness of GBM, analyzing exosomal cargo and functional dynamics offers unique opportunities to unravel the molecular mechanisms underlying tumor progression and therapeutic failure. MtoZ Biolabs provides an end-to-end Glioblastoma Exosome Research Service that enables researchers to harness the diagnostic and functional potential of exosomes in GBM with high precision and scientific rigor.
Service at MtoZ Biolabs
MtoZ Biolabs has established a comprehensive glioblastoma exosome research platform that integrates advanced multi-omics, imaging, and functional assays to support various stages of discovery and validation. Our solutions include:
💠Custom Experimental Design
💠Exosome Isolation and Purification
💠Exosomal Cargo Multi-Omics (Proteomics, Transcriptomics, Lipidomics, and Metabolomics)
💠Exosome Labeling and Tracking
💠Functional Assays (In Vitro & In Vivo)
💠Exosomal Biogenesis and Identification Studies
Analysis Workflow
Service Advantages
☑️Advanced Analysis Platform: MtoZ Biolabs established an advanced Glioblastoma Exosome Research Service platform, guaranteeing reliable, fast, and highly accurate analysis service.
☑️Integrated Multi-Omics Capability: We combine proteomics, transcriptomics, lipidomics, and metabolomics to deliver a comprehensive understanding of glioblastoma–related exosomal biology.
☑️End-to-End Customization: From isolation and characterization to functional validation, all steps are tailored to your sample type, research goals, and specific glioblastoma subtype.
☑️Strict Quality Control & Confidentiality: All workflows follow standardized SOPs with validated reagents, ensuring data integrity, compliance, and full confidentiality of client projects.
Applications
Our glioblastoma-focused exosome services support a wide range of academic and translational research goals:
1️⃣Non-Invasive Biomarker Discovery: Identification of glioblastoma-specific exosomal miRNAs or proteins in CSF or plasma for early diagnosis and monitoring.
2️⃣Tumor Microenvironment Analysis: Understanding exosome-mediated crosstalk between glioma cells and astrocytes, endothelial cells, or immune cells.
3️⃣Therapy Resistance Mechanism Elucidation: Investigating how exosomal transfer of RNAs or proteins contributes to the development of resistance to therapeutic interventions.
4️⃣Drug Delivery Development: Engineering exosomes as natural carriers for siRNA, drugs, or immunomodulators targeting GBM cells.
5️⃣Immunotherapy Enhancement: Evaluating the impact of tumor-derived exosomes on T cell activation, exhaustion, and immune checkpoint expression.
Sample Submission Suggestions
We accept the following sample types:
Samples should be stored at -80°C and shipped on dry ice. Avoid repeated freeze–thaw cycles.
*Please consult us for tailored collection and storage protocols to maximize data quality.
Deliverables
1. Comprehensive experimental details (materials, instruments, and methods)
2. Raw data
3. Processed omics data files
4. Quality control reports (NTA, Western blot, TEM images)
5. Functional assay results
6. Bioinformatics analysis
7. Customized report based on project requirements
MtoZ Biolabs is committed to advancing glioblastoma research by providing a comprehensive, high-resolution exosome analysis platform tailored to the complexities of brain tumor biology. Free project evaluation, welcome to learn more details!
Related Services
Pancreatic Cancer Exosome Research Service
Exosome-Based Drug Delivery Service
Exosome Antibody Development Service
How to order?
