Resources

Proteomics Databases



Metabolomics Databases

• • How Is Histone Butyrylation Linked to Short-Chain Fatty Acid Metabolism?

  With the rapid advancement of epigenetics, histone post-translational modifications (PTMs) have emerged as a central avenue for elucidating mechanisms of gene expression regulation. In recent years, histone butyrylation (Kbu), an emerging type of acylation modification, has attracted increasing attention in the life sciences. Concurrently, short-chain fatty acids (SCFAs), key metabolites produced by the gut microbiota, are increasingly recognized for their roles in host metabolism and epigenetic regul......

• • How Does Butyryl-CoA Drive Histone Kbu Formation?

  In the field of epigenetic regulation, the repertoire of histone post-translational modifications is continually expanding. Lysine butyrylation (Kbu), a recently recognized acylation modification, has gradually emerged as a key regulator of chromatin architecture and gene expression. Compared with classical acetylation, Kbu possesses a longer carbon chain and greater hydrophobicity, enabling it to exert distinct effects on protein conformation and molecular interactions. Meanwhile, butyryl coenzyme A ......

• • How to Perform Histone Acetylation Analysis?

  Histone acetylation, as one of the most well-established epigenetic modifications, plays a central role in regulating chromatin structure and activating gene transcription. Acetyl groups neutralize the positive charge of lysine residues, thereby weakening the interaction between DNA and histones and promoting the transition of chromatin from a compact to a more open state. This dynamic regulatory process is widely involved in biological processes such as cell differentiation, tumorigenesis, and immune......

• • Ultimate Guide to Antibody Characterization Assays: Methods and Applications

  With the rapid advancement of antibody drug development, antibody characterization has evolved from a discrete technical step into a core capability spanning the entire research and development pipeline. From early-stage molecular design to late-stage quality control, the extent to which antibody structure and function are comprehensively elucidated directly determines the reliability of research outcomes and the success of drug development. Therefore, a systematic understanding of the technical frame......

• • How Professional Antibody Characterization Platforms Accelerate Biotherapeutic Development?

  In the current era of rapid biotherapeutic development, antibody drugs have emerged as central agents in the treatment of cancer, autoimmune disorders, and infectious diseases. Nevertheless, prolonged development timelines and high attrition rates from candidate antibody screening to clinical drug approval remain significant challenges in the industry. Within this context, antibody characterization has evolved from a supporting analytical technique into a critical technological milestone throughout th......

• • Mass Spectrometry-Based Targeted Metabolomics: The Science Behind Precision

  In modern life sciences research, metabolomics has emerged as a critical tool for elucidating biological system functions and disease mechanisms. In particular, mass spectrometry-based targeted metabolomics, characterized by high sensitivity, high specificity, and robust quantitative accuracy, has become a preferred approach for mechanism validation and biomarker investigation. Targeted metabolomics refers to a research strategy focused on the quantitative analysis and dynamic monitoring of predefined......

• • Immunopeptidomics Powers Vaccine Design and Target Discovery

  Vaccine design has traditionally relied on protein sequence-based prediction and immunological assays. However, when applied to complex biological contexts, such as viral variants or tumor neoantigens, this strategy is often constrained by insufficient precision in antigen identification. Immunopeptidomics, an emerging field that integrates mass spectrometry with immunobiology, is providing innovative approaches for efficient vaccine design and precise target discovery. What Is Immunopeptidomics? 1. ......

• • What Is The Link Between Histone β-Hydroxybutyrylation And Ketone Body Metabolism?

  Over the past decade, the intersection of epigenetics and metabolic regulation has emerged as a frontier in life sciences research. Histone modifications play a crucial role in regulating gene expression. Beyond traditional methylation and acetylation, researchers have recently identified a novel histone modification, β-hydroxybutyrylation (Kbhb). Remarkably, this modification is closely linked to energy metabolism, particularly ketone body metabolism, offering new insights into how cells respond to e......

• • How to Perform Quantitative Exosome Proteomics Using TMT/DIA?

  Exosomes are cell-secreted vesicles with diameters ranging from 30 to 150 nm, widely distributed in blood, urine, and other body fluids. Rich in proteins, RNA, and lipids, exosomes serve as critical mediators of intercellular signaling and play significant roles in disease diagnosis, drug target identification, and therapeutic research. With advances in mass spectrometry, high-throughput and precise protein quantification methods have become essential tools for exosome research. Among these, Tandem Ma......

• • What Are the Common Methods for Histone Propionylation Analysis?

  In the rapidly evolving field of epigenetics, post-translational modifications of histones have emerged as a central focus in life sciences research. Among these, histone propionylation (Kpr), an emerging lysine acylation modification, has attracted considerable attention due to its potential roles in metabolic regulation and gene expression. Histone propionylation occurs on lysine residues and is chemically similar to acetylation, but with an additional carbon atom (C3). Even this minor structural di......