Resources

Proteomics Databases



Metabolomics Databases

• • Scoping an MRM Quantitation Project: Transition Design, Sample Count, and Validation Deliverables

  MRM quantitation projects move faster when scope is defined before samples ship. Teams often request a large peptide panel and high sample count without confirming whether transitions are optimized in matrix, whether cycle time supports the panel size, or whether the final report must satisfy biomarker validation, biopharmaceutical QC, or internal research standards.

• • Multiple Reaction Monitoring or Discovery Proteomics? Matching MRM to Biomarker Validation and QC Needs

  Quantitative proteomics projects rarely fail because teams lack mass spectrometry capability. They fail because the selected workflow does not match the study stage or evidence standard required for the next decision. One team may need to survey thousands of proteins to generate biomarker hypotheses. Another may need to measure ten predefined peptides across five hundred clinical samples with tight reproducibility.

• • Weak or Missing MRM Peaks? Troubleshooting Transition Selection, Matrix Effects, and LC Separation

  An MRM assay can be fully configured yet fail to deliver usable quantitative data. Transitions may be defined, internal standards may be spiked, and the LC-MS run may complete without error, yet target peptides show weak peaks, missing transitions, poor linearity, or high variability across replicates.

• • What is LC-MS in proteomics?

  Learn what LC-MS means in proteomics, how liquid chromatography and mass spectrometry work together, how LC-MS differs from LC-MS/MS, and common uses in protein analysis.

• • What is LC-MS in bioactivity screening and proteomics?

  Learn what LC-MS means in bioactivity screening and proteomics, how each field uses liquid chromatography mass spectrometry, and where screening and proteomics workflows overlap.

• • Non-Reducing Peptide Mapping vs. Intact Mass Analysis for Disulfide Bond Mapping

  Compare non-reducing peptide mapping and intact mass analysis for disulfide bond mapping, including method differences, decision workflow, use cases, and combined characterization strategies.

• • MS-based proteomics: A short introduction to the core concepts of proteomics and mass spectrometry

  A short introduction to MS-based proteomics covering core concepts of proteomics and mass spectrometry, including peptide measurement, MS/MS, PSM assignment, protein inference, and quantitation basics.

• • Mass Spectrometry: Structural Proteomics

  Learn how mass spectrometry supports structural proteomics via HDX-MS, cross-linking MS, native MS, and connectivity mapping for biologics and complexes.

• • Mass Spectrometry Proteomics: Turning Complex Protein Samples into Interpretable Biological Evidence

  Learn how mass spectrometry proteomics converts complex protein samples into interpretable evidence via LC-MS/MS, inference, and quantitation.

• • Mass Spectrometry Proteomics: Methods, Workflow, and Applications

  Learn mass spectrometry proteomics methods, LC-MS/MS workflow, quantification strategies, applications, and project design for protein analysis.