Resources
Proteomics Databases
Metabolomics Databases
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• Application of High-Resolution Mass Spectrometry in Molecular Weight Identification
In proteomics and biopharmaceutical research and development, molecular weight determination is a fundamental yet critical analytical step. Accurate molecular weight measurement is essential for recombinant protein expression verification, monoclonal antibody quality control, and structural characterization of unknown proteins. Conventional methods such as SDS-PAGE can provide approximate molecular weight information; however, their limited resolution cannot fully meet the requirements of modern bioan......
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• How HPLC-MS/MS Enables Accurate Protein Disulfide Bond Localization Analysis?
Disulfide bonds are critical structural elements that support the higher-order structure and function of proteins. Their formation and disruption play key roles in protein folding, structural stability, and functional regulation. Accurate identification of disulfide-bond positions in proteins is essential for understanding protein conformation, developing biopharmaceuticals, and investigating disease mechanisms. However, because disulfide bonds are embedded in complex protein matrices, their localizat......
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• What Drives Cost in a Peptide Mapping Service?
Learn what drives peptide mapping service cost, including product complexity, digestion strategy, sample number, PTM scope, reporting depth, and rework risk for biologics projects.
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• Peptide Mapping Service or In-House Testing?
Compare peptide mapping service with in-house LC-MS/MS or HPLC testing by documentation needs, internal capacity, reporting depth, and project phase for biologics characterization.
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• Before You Submit: Peptide Mapping Service Essentials
Prepare your peptide mapping service submission with this pre-submission checklist covering reporting goals, reference sequence, sample purity, buffer review, and expected deliverables.
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• Peptide Mapping Service for Biologics Characterization
Learn how peptide mapping service supports biologics characterization through LC-MS/MS sequence coverage, PTM localization, and comparability evidence for therapeutic proteins.
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In allergen-related antibody studies, the main difficulty is often not whether antibody reactivity can be detected, but whether that reactivity can be converted into a workable set of candidates for downstream investigation. Many projects begin with a broad biological question rather than a predefined target.
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Selecting PhIP-Seq for allergen-related antibody profiling helps define candidate priorities before targeted validation by supporting peptide-level reactivity analysis, protein-level ranking, and downstream study planning.
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• Common Pitfalls and Optimization Strategies in Shotgun Proteomics Analysis
Shotgun proteomics is one of the core technologies in modern proteomics research. Owing to its high-throughput capacity and broad proteome coverage, it plays an important role in many areas of the life sciences. However, in practical applications, researchers often encounter challenges related to sample preparation, instrument configuration, and data analysis, which may affect the depth of proteome coverage, data accuracy, and reproducibility. This article systematically summarizes common misconceptio......
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• What Is Site-Specific Histone Ubiquitination Analysis?
Histone ubiquitination is an important epigenetic modification that regulates chromatin structure and gene expression through the covalent attachment of the small regulatory protein ubiquitin to lysine residues on histones. Ubiquitination at different histone sites has distinct functions in transcriptional regulation, chromatin remodeling, and DNA damage repair, and its role in gene silencing or activation often depends on the modification status of specific sites. Site-specific histone ubiquitination......
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