Resources

Proteomics Databases



Metabolomics Databases

• • The Crucial Role of Mass Spectrometry in Acetylproteomics: From Identification to Quantification

  Protein post-translational modifications (PTMs) constitute a central mechanism for regulating cellular functions. Among them, acetylation, one of the most prevalent PTMs, plays critical roles in gene expression regulation, chromatin remodeling, and metabolic processes. As proteomics research advances, systematic identification and quantification of acetylation are essential to elucidate its mechanistic roles in disease progression, cellular stress responses, and drug effects. Mass spectrometry (MS), a......

• • LC‑MS/MS Techniques for Glycosylation Site Occupancy Quantification

  Glycosylation is one of the most prevalent and structurally complex post-translational modifications in eukaryotic organisms. A substantial body of evidence has demonstrated that glycans are not only involved in protein folding, secretion, and intercellular recognition, but also play critical roles in regulating protein biological activity, stability, and immune-related functions. In studies of antibody therapeutics, recombinant protein drugs, and disease biomarkers, in addition to glycan structural c......

• • How to Analyze Histone Succinylation Sites?

  Histones are core structural components of chromatin, and diverse covalent modifications of lysine residues within histones play critical regulatory roles in gene expression and chromatin dynamics. Succinylation (Ksucc), an emerging histone modification, involves the covalent addition of negatively charged succinyl groups to lysine residues. This modification not only markedly alters the electrostatic properties of nucleosomes and chromatin accessibility, but also links cellular metabolic status to ep......

• • How to Quantify Histone Succinylation Levels?

  Histone succinylation is an important post-translational modification that regulates chromatin structure and gene expression through the covalent addition of succinyl groups to lysine residues. This modification not only alters the electrostatic properties of nucleosomes and promotes chromatin accessibility, but also participates in transcriptional activation, DNA damage repair, and cellular metabolic regulation. Quantitative analysis of histone succinylation levels enables precise assessment of gene ......

• • Why Intact Mass Analysis Can Miss Minor Variants

  Learn why intact mass analysis can miss minor variants in biologics, including resolution limits, low abundance, and deconvolution issues, plus practical steps to improve detection.

• • When Targeted Mass Spectrometry Outperforms Discovery

  Learn when targeted mass spectrometry outperforms discovery profiling for fixed-panel quantitation, cohort validation, selective MRM or PRM acquisition, and QC reporting.

• • What Affects Targeted Proteomics Project Costs?

  Learn what affects targeted proteomics project costs, including panel size, sample matrix, MRM or PRM platform, assay development, sample number, and reporting depth.

• • What Affects Parallel Reaction Monitoring Costs?

  Learn what drives parallel reaction monitoring cost, including assay development, isolation windows, panel size, matrix complexity, cohort size, and reporting before requesting a quote.

• • What Affects AQUA Peptide Assay Development Costs?

  Learn what drives AQUA peptide assay development cost, including synthesis, labeling, calibration design, matrix validation, panel size, and reporting before requesting a quote.

• • What Affects Absolute Protein Quantification Costs?

  Learn what affects absolute protein quantification costs, including AQUA standard design, calibration scope, sample matrix, MRM or PRM platform, and QC reporting depth.