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      Proteomics Databases

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    • • Zebrafish High Throughput Screening

      Zebrafish High Throughput Screening is a rapidly emerging technology in the fields of biomedical research and drug development. As a vertebrate model, zebrafish combines the high-throughput capabilities of in vitro experiments with the systemic physiological advantages of mammalian models, making it an ideal bridge between basic research and clinical applications. The core of zebrafish high throughput screening lies in utilizing its biological characteristics—embryonic transparency, rapid development ......

    • • Quantitative Proteomics Techniques

      In modern life science research, merely identifying the presence of proteins is no longer sufficient. Scientists are increasingly concerned with deeper questions: How much is a protein expressed? What are its dynamic trends? Is it involved in disease pathogenesis? Addressing these questions requires the power of quantitative proteomics techniques. These approaches not only comprehensively identify the proteins present in a sample but also precisely measure their expression levels, making them indispen......

    • • Organoid High Throughput Screening

      Organoid high throughput screening represents a revolutionary upgrade in the development of in vitro models. Conventional cell lines, while enabling high-throughput analysis, lack the native microenvironment and three-dimensional (3D) structure required to faithfully replicate human disease. Animal models, though physiologically relevant, remain constrained by high costs, extended timelines, and ethical barriers. The emergence of organoids overcomes these limitations. Derived from stem cells or tissue......

    • • High Throughput Screening (HTS) Significance in Drug Discovery

      The high throughput screening (HTS) significance in drug discovery cannot be overstated, as it is integral to the identification and optimization of potential drug candidates. Before the successful development of a new drug, it typically must emerge from an initial pool of millions of candidate molecules. This process resembles isolating a single pearl from the depths of an ocean. One of the pivotal technologies enabling this formidable task is high throughput screening (HTS). As the foundational step......

    • • Drug Discovery High Throughput Screening

      Drug discovery high throughput screening is a cornerstone technology in modern pharmaceutical research. It enables the systematic and rapid evaluation of thousands to millions of small molecules, biomolecules, or natural products for potential biological activity using automated platforms and large-scale experimental systems. By integrating robotics, micro-volume liquid handling, multiplexed detection systems, and data analytics, drug discovery high throughput screening significantly enhances the effi......

    • • High Throughput Compound Screening

      High throughput compound screening is a pivotal technology designed for the rapid evaluation and identification of biologically active compounds from large-scale chemical libraries. This technique enables the screening of thousands to millions of compounds within a short time frame, making it indispensable in the early stages of drug discovery. Pharmaceutical companies and research institutions leverage this approach to systematically examine vast compound collections, aiming to identify chemical enti......

    • • Mass Spectrometry High Throughput Screening

      Mass spectrometry high throughput screening is an analytical approach that leverages mass spectrometry to rapidly identify and quantify compounds within complex biological matrices, without the need for prior separation. This technique plays a crucial role in enabling precise, high-throughput molecular analysis directly from biological samples.   In the pharmaceutical industry, it is frequently employed to screen thousands of candidate compounds to identify those with potential therapeutic efficacy. B......

    • • Full Name of MS/MS (Tandem Mass Spectrometry)

      MS/MS (Tandem Mass Spectrometry), also referred to as MS2, is a powerful analytical technique widely used for structural elucidation of molecules. In this method, molecules are first ionized and separated based on their mass-to-charge ratio (m/z) in the first stage of mass spectrometry (MS1). Selected precursor ions are then further fragmented in a second mass spectrometry stage (MS2 or MS/MS), enabling detailed structural analysis of the original compound.   The core workflow of MS/MS (Tandem Mass Sp......

    • • Mass Spectrometry (MS)

      Mass spectrometry (MS) is an analytical technique used to determine the molecular mass and structural characteristics of compounds within a sample. By analyzing the mass-to-charge ratio (m/z) and relative abundance of ionized molecules, mass spectrometry (MS) enables the identification of diverse compounds, quantitative assessment of sample components, and elucidation of molecular structures. This technique is widely applied across multiple disciplines, including chemistry, biology, pharmaceutical dev......

    • • PROTAC Drug Discovery

      PROTAC drug discovery represents an innovative approach to therapeutic development that leverages the technology of proteolysis-targeting chimeras (PROTACs) to achieve targeted protein degradation. A PROTAC molecule typically consists of two functional ligands: one specifically binds to the target protein, while the other recruits an E3 ubiquitin ligase. These ligands are connected via an appropriate linker, forming a bifunctional molecule that facilitates ubiquitination and subsequent proteasomal deg......

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