Resources

Proteomics Databases



Metabolomics Databases

• • DIA Proteomics Services for Cancer Biomarker Discovery

  Cancer is a highly heterogeneous and complex disease, characterized by diverse molecular mechanisms and intricate biological pathways underlying its initiation and progression. Despite continued advancements in therapeutic strategies, early diagnosis remains a critical determinant for improving cancer prognosis. The discovery and validation of biomarkers represent a pivotal approach for enabling early detection, disease surveillance, and therapeutic response prediction. Among the various omics .......

• • Typical Applications of DIA-Based Quantitative Proteomics in Clinical Research

  In the post-genomic era, proteomics has emerged as a powerful approach for elucidating disease mechanisms, identifying biomarkers, and informing therapeutic decisions. Mass spectrometry (MS), with its high throughput, label-free capabilities, and broad dynamic range, holds significant promise in clinical research. Among various MS acquisition methods, Data-Independent Acquisition (DIA) has become a central technology in clinical proteomics, owing to its superior data reproducibility and comprehensive ......

• • DIA vs DDA Proteomics: Key Differences and Applications Explained

  In proteomics research, mass spectrometry serves as a central technique for elucidating cellular protein composition, changes in protein abundance, and post-translational modifications. Notably, liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based analytical approaches have been extensively employed across a range of domains, including basic research, clinical studies, and biomarker discovery. Among various acquisition strategies, Data-Dependent Acquisition (DDA) and Data-Independent .......

• • Principles and Workflow of DIA Proteomics: A Case Study of SWATH-MS

  In the post-genomic era, researchers have increasingly turned their attention to dynamic changes at the proteomic level, aiming to address the limitations of genomic and transcriptomic data. Mass spectrometry (MS), as a central tool in modern proteomics, continues to expand both the depth and breadth of biomedical research. Among the various acquisition strategies, Data-Independent Acquisition (DIA)—particularly the SWATH-MS technique—has emerged as a prominent approach in quantitative proteomics, owing....

• • Advantages and Disadvantages of SWATH-MS

  What Is SWATH-MS? SWATH-MS is a mass spectrometry technique based on data-independent acquisition (DIA), first introduced by SCIEX. Unlike the traditional data-dependent acquisition (DDA) approach, SWATH-MS does not rely on on-the-fly precursor ion selection. Instead, it divides the full m/z scan range into a series of fixed-width windows and fragments all ions within each window, thereby systematically acquiring all detectable fragment ion spectra. Its core strengths include high throughput, excellent.....

• • SWATH-MS Data Analysis Workflow and Common Pitfalls

  Introduction: The Power of SWATH-MS Relies on Proper Data Analysis SWATH-MS (Sequential Window Acquisition of All Theoretical Fragment Ion Spectra), a representative technique in data-independent acquisition (DIA), has significantly advanced large-scale, highly reproducible, and label-free quantitative proteomics. However, the intrinsic complexity of the data poses challenges, including intricate analysis workflows, strong parameter dependencies, and high variability in analytical outcomes. This article....

• • Application and Analysis of Advantages of SWATH-MS in Plasma Proteomics

  Plasma is among the most complex and research-relevant biological sample types. It carries protein signatures secreted from tissues throughout the body and is widely used in biomarker discovery, early disease diagnosis, and precision medicine due to its accessibility and high stability. However, plasma proteomics faces two major challenges: 1. An extremely wide dynamic range (>10¹⁰), with a small number of high-abundance proteins (e.g., albumin, globulin) accounting for over 90% of the total protein .......

• • How to Use SWATH-MS for Label-Free Protein Quantification?

  In proteomics research, label-free quantification (LFQ) has become an increasingly prominent approach for differential protein profiling and mechanistic studies. This is largely attributed to its advantages, including the elimination of costly labeling reagents, scalability with respect to sample number, and compatibility with clinical specimens. Among the diverse LFQ strategies, SWATH-MS—representing a data-independent acquisition (DIA)-based method—integrates the broad identification capability of........

• • Yellow Skin: Glycation? MtoZ Biolabs Unravels the Mystery

  Skin - an essential part of our body, not only a marker of external beauty, but also an important reflection of our health status. Glycation is a natural process in the human body that occurs when sugars such as glucose or fructose bind with skin's collagen and elastin proteins, making the skin's collagen stiff, causing the skin to lose its natural structural support, resulting in wrinkles, fine lines, and sagging. Skin glycation is a non-enzymatic biochemical process that involves the reaction betwee......

• • Explore Protein Peptides: MtoZ Biolabs' Solution

  Food protein bioactive peptides are small molecular peptides composed of short-chain amino acids. They not only exist naturally in food but can also be derived from protein degradation in food. These peptides have multiple biological activities, including antioxidant, anti-inflammatory, hypotensive, and immune-regulating properties, making them of significant value in the development of healthy and functional foods.   The Importance of Bioactive Peptides Bioactive peptides are organic, isolated fragme......