Resources

Proteomics Databases



Metabolomics Databases

• • Cancer Genomics and Proteomics

  Cancer genomics and proteomics are two foundational disciplines for exploring the molecular mechanisms of cancer. They respectively reveal the nature and evolution of tumors from the perspectives of genetic information and protein function. Cancer genomics focuses on alterations at the DNA level in cancer cells, including gene mutations, copy number variations, chromosomal rearrangements, and epigenetic modifications, all of which constitute the genetic basis of tumorigenesis. In contrast, cancer prot......

• • GTEx Proteomics

  GTEx (Genotype-Tissue Expression) Proteomics represents a systematic research initiative that extends the scope of the original GTEx project. It aims to construct a comprehensive landscape of protein expression across diverse human tissues and to further investigate how genetic variation influences the spatial distribution and functional modulation of proteins. While the initial GTEx project primarily focused on uncovering inter-individual variability and tissue specificity in gene expression using ........

• • Photoaffinity Labeling in Target and Binding Site Identification

  Photoaffinity labeling in target and binding site identification represents an advanced approach at the interface of chemistry and biotechnology. It is designed to accurately elucidate the interactions between small molecules and their protein targets, with a particular focus on the spatial localization and binding mechanisms of interaction sites. In contemporary drug discovery and molecular mechanism studies, understanding where and how small molecules engage with target proteins underpins the .........

• • TAILS Proteomics

  TAILS proteomics (Terminal Amine Isotopic Labeling of Substrates) is a high-resolution proteomic strategy designed to characterize the structural features of protein N-termini and to identify protease cleavage sites. This approach involves chemical labeling of protein N-terminal amines using isotopic reagents, followed by selective enrichment and mass spectrometry analysis, enabling sensitive and systematic detection of both native N-termini and neo-N-termini generated by proteolytic processing.

• • Detection Methods for Changes in Protein Glycosylation Levels

  Glycosylation is a crucial post-transcriptional modification process that influences the folding, stability, activity, and intercellular interactions of proteins. There are various methods to determine if the glycosylation modification level on a protein has changed, and each method has its characteristics and applicable scenarios. Here are some commonly used techniques: 1. Mass Spectrometry (MS) MS is a very powerful tool, especially when combined with liquid chromatography (LC-MS/MS)

• • Detection of Protein Phosphorylation Levels at Specific Sites

  Quantitative analysis of phosphorylation levels plays a crucial role in studying cell signaling, disease development, and drug mechanisms. The phosphorylation level at specific sites reflects the activity status of proteins and their involvement in biological processes.

• • Principles of Proteomics

  Proteomics is an important research field in the biopharmaceutical industry, which focuses on the study of the entire collection of proteins in an organism, helping us to gain deeper insights into the physiological and pathological processes of living organisms. Proteins are the most diverse and functionally rich molecules in living systems, and understanding the principles of proteomics is pivotal in exploring the molecular mechanisms within cells and organisms.

• • The Similarities and Differences in Histone Modifications in Glycosylation and Acetylation

  Within each tiny nucleus of our bodies, a multitude of different protein molecules are dancing together in the choreography of life. Some of them are histones, whose importance is undeniable. Histone modifications can impact the expression of billions of genes throughout the body, making them comparable to an orchestra within the nucleus.

• • Glycomics Unveiling the Full Scope of Glycan Modification Regulation

  Glycosylation, as an important protein modification, is a common regulatory mechanism in cells. Glycan modifications on proteins can regulate their structure and function, thereby affecting biological processes in organisms. Glycomics, as a significant branch in the exploration of protein modifications, aims to study glycan modifications on proteins.

• • CIq Affinity Measurement of Recombinant Protein Drugs

  Recombinant protein drugs refer to protein products derived from animals and plants through biotechnological research and development, which have certain biological activity and can prevent, diagnose, and treat human, animal, and plant diseases. Compared to small molecule drugs, recombinant protein drugs have advantages such as high activity, high specificity, and low toxicity, making them favored by researchers.