Resources

Proteomics Databases



Metabolomics Databases

• • Top 5 Methods for Protein Structure Analysis and Their Applications

  The function of a protein is intrinsically linked to its three-dimensional structure. Protein structure analysis not only facilitates the interpretation of biological behavior but is also extensively utilized in diverse research areas, including drug discovery, antibody engineering, and the elucidation of metabolic pathways. Currently, researchers have access to multiple analytical techniques for analyzing protein structure, each with distinct advantages, limitations, and suitability for specific protein...

• • Protein Primary Structure Characterization Methods

  Proteins are fundamental biomolecules essential for life processes, and their structures are intrinsically linked to their functions. The primary structure of a protein refers to the linear sequence of amino acids, which serves as the foundation for the formation of higher-order structures such as secondary, tertiary, and quaternary conformations. Accurate determination of a protein’s primary structure is critical for elucidating its biological functions, investigating structural alterations, developing....

• • How Single Cell Proteomics Accelerates Precision Medicine

  Precision medicine aims to formulate scientifically informed diagnostic and therapeutic strategies tailored to individual patient characteristics. This approach fundamentally depends on a deep understanding of disease mechanisms and the ability to monitor therapeutic responses dynamically. With the advancement of omics technologies, platforms such as genomic sequencing, transcriptome analysis, and single-cell RNA sequencing have laid the groundwork for precision medicine. However, precision medicine......

• • Single Cell Proteomics Strategies in Immunology Research

  The immune system exhibits a highly sophisticated capacity for dynamic regulation, playing pivotal roles in processes such as host defense, tumor surveillance, autoimmunity, and tissue repair. Emerging evidence indicates that immune cells display substantial functional heterogeneity depending on developmental stages, microenvironmental cues, or external stimuli. In recent years, advances in single-cell technologies have significantly enhanced the resolution at which immunological processes can be studied...

• • How to Efficiently Identify Protein Structures: Technologies and Tools Explained

  The three-dimensional structure of a protein is fundamental for understanding its biological functions, molecular mechanisms, and therapeutic potential. Compared to sequence analysis, protein structure determination provides greater explanatory power in elucidating functional mechanisms, mapping protein interaction networks, and facilitating drug discovery. Consequently, how to identify protein structures effectively has become a central challenge in contemporary life sciences. With advances in both .......

• • Optimized Workflow for Single Cell Proteomics Using Mass Spectrometry

  Single cell proteomics (SCP) represents one of the most innovative technologies in modern life sciences, enabling high-resolution analysis of protein expression and functional dynamics at the individual cell level. Particularly in highly heterogeneous systems such as tumors, the immune system, and stem cell populations, SCP offers a powerful approach to elucidate cell fate decisions, state transitions, and disease progression from a functional standpoint. Within the SCP experimental framework, the .......

• • Methods and Applications of Protein Circular Dichroism (CD) Spectroscopy

  Circular Dichroism (CD) spectroscopy is a chiroptical technique that detects the differential absorption of left- and right-circularly polarized light by chiral molecules. It has been widely employed to investigate protein secondary structure, conformational dynamics, thermal stability, and folding pathways. Owing to its non-destructive nature, high sensitivity, and ease of use, CD spectroscopy has become an essential tool for protein structural characterization. In the fields of life sciences and ......

• • How to Interpret High-Dimensional Data in Single Cell Proteomics

  Single cell proteomics (SCP) is rapidly emerging as a powerful tool for dissecting cellular heterogeneity and the dynamic nature of biological processes. By profiling protein expression at the resolution of individual cells, researchers can gain critical insights into the molecular underpinnings of tissue homeostasis, disease progression, immune responses, and more. However, SCP data are inherently high-dimensional, typically involving the quantification of hundreds to thousands of proteins per cell........

• • Integrating Single Cell Proteomics with scRNA-seq: Methods and Tools

  The rapid advancement of single-cell sequencing technologies has enabled researchers to dissect cellular heterogeneity at single-cell resolution. Among various approaches, single-cell RNA sequencing (scRNA-seq) primarily captures the transcriptomic landscape by profiling mRNA expression, whereas single cell proteomics (scProteomics) offers insights into protein-level expression, which more directly reflects functional cellular output. These two modalities represent distinct yet complementary dimension......

• • Using CD Spectroscopy to Evaluate Protein Thermal Stability

  Protein thermal stability is a key indicator of structural integrity and functional retention, and it is widely applied in basic research, protein engineering, and biopharmaceutical development. Circular Dichroism (CD) spectroscopy is a sensitive, rapid, and low–sample-volume technique commonly used to monitor conformational changes in protein secondary structure. It is particularly suitable for evaluating thermal denaturation behavior and thermal stability parameters such as the melting temperature .......