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Proteomics Databases
Metabolomics Databases
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Ion channel drug discovery is an intricate process that integrates the study of membrane protein functions with high-throughput screening technologies. This approach aims to identify and develop compounds that specifically target ion channels to treat diseases associated with electrophysiological imbalances. Ion channels, which regulate the transmembrane transport of ions like sodium, potassium, calcium, and chloride, are crucial for cellular excitability, signal transduction, and osmotic regulation. ......
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X-ray analysis of protein is a fundamental technique for determining the three-dimensional structures of proteins at atomic resolution. This method leverages X-ray diffraction principles to probe the atomic arrangement within protein crystals, enabling detailed insights into protein function and molecular mechanisms. The ability to obtain high-resolution structural data through biophysical characterization is essential for elucidating protein roles in cellular processes, guiding rational drug design, ......
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Proteomic biomarkers are specific proteins or expression profiles indicative of diseases, pathological conditions, or physiological changes, identified through comprehensive protein analysis. These biomarkers, present in bodily fluids such as blood, urine, and saliva, are pivotal in linking protein levels, structures, or modifications to the onset, progression, treatment response, or prognosis of diseases. The clinical relevance of proteomic biomarkers is profound, especially for early disease diagnos......
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• Proteomics in Drug Discovery
Proteomics in drug discovery refers to the comprehensive analysis of all proteins in a biological system to investigate their critical roles throughout the drug development process. As the primary functional molecules in living organisms, proteins are essential participants in nearly every cellular process, including gene regulation, signal transduction, and metabolism. Proteomics in drug discovery provides crucial biological insights that support various stages of pharmaceutical research, such as tar......
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SILAC labeling is a widely utilized technique in proteomics that enables precise quantitative comparison of protein expression across different biological samples under defined cell culture conditions. This method incorporates stable isotope-labeled amino acids into cellular proteins during cultivation, allowing experimental and control groups to be distinguished based on isotopic differences. As these isotopically labeled amino acids do not interfere with protein structure or function, SILAC labeling......
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• Protein-Protein Interactions Pull-Down Assays
Protein-protein interactions pull-down assays are biochemical techniques that utilize affinity enrichment principles to investigate the physical binding relationships between proteins within cellular environments. By mimicking protein binding states in vitro, these assays enrich target complexes, which are subsequently identified and qualitatively analyzed using various detection methods. This approach is instrumental in elucidating signaling pathways, regulatory networks, and functional complexes inv......
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The synthesis of semaglutide refers to the integrated chemical and biological process of constructing this long-acting glucagon-like peptide-1 (GLP-1) receptor agonist. As a peptide-based therapeutic, semaglutide has demonstrated superior efficacy in the treatment of type 2 diabetes and obesity. Its primary mechanism of action involves mimicking the function of endogenous GLP-1 to regulate blood glucose and body weight by enhancing insulin secretion, delaying gastric emptying, and suppressing appetite......
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• Target Identification in Drug Discovery Process
Target identification in drug discovery process constitutes a foundational step in modern drug development, serving as a critical prerequisite for ensuring that therapeutic agents exert their intended biological effects. A target refers to the specific molecular entity—typically a protein such as an enzyme, receptor, or ion channel—that a drug interacts with to modulate its activity or signaling, thereby altering cellular functions and influencing disease progression. Due to the inherent complexity of .....
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Visual proteomics represents a rapidly evolving interdisciplinary domain at the intersection of proteomics and vision science. It is dedicated to systematically elucidating the composition, function, regulatory mechanisms, and dynamic modulation of proteins in the visual system. As one of the most intricate and refined sensory systems in humans, vision depends on the coordinated activity of thousands of proteins across processes such as phototransduction, signal relay, energy metabolism, cellular ..........
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• Activity-Based Protein Profiling of the Serine Hydrolases
Activity-based protein profiling of the serine hydrolases is an analytical approach that integrates enzyme-reactive probe chemistry with high-resolution mass spectrometry to investigate the expression patterns and functional states of serine hydrolase family members. Serine hydrolases are ubiquitous in both eukaryotic and prokaryotic systems, playing vital roles in digestion, immune regulation, development, and apoptosis. Their catalytic mechanism involves a conserved serine residue at the active site......
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