Resources
Proteomics Databases
Metabolomics Databases
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10x Genomics sequencing is a cutting-edge high-throughput sequencing technology that leverages microfluidic systems combined with innovative sequencing strategies to deliver highly detailed and accurate genomic information. The cornerstone of this technology is its capability to perform single-cell sequencing, effectively distinguishing the genomic information of individual cells from others. This single-cell resolution significantly enhances our comprehension of complex biological systems and disease......
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• Single-Cell Sequencing Microbiome
Single-cell sequencing microbiome enables the analysis of complex microbial communities at the single-cell level. By isolating individual microbial cells and performing genomic sequencing, this technology provides an unprecedented level of detail for observing the diversity and functions of microbial ecosystems. This capability has found applications in a variety of fields, particularly in environmental science, clinical research, and biotechnology development. For instance, in human health, single-ce......
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• Protein Structure X-Ray Crystallography
Protein structure X-ray crystallography is a technique employed to elucidate the three-dimensional structures of proteins. Since the early 20th century, following the discovery of X-rays, scientists have developed methodologies to utilize this powerful tool to explore the internal structures of protein molecules. This technology allows researchers to observe protein structures at atomic precision, which is fundamental for understanding their functions. Proteins are responsible for numerous critical ro......
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• Single-Cell Sequencing Immune Cells
Single-cell sequencing immune cells has emerged as an innovative technology in recent years, designed to analyze the genomic, transcriptomic, or other omics data of individual immune cells. Traditional sequencing methods typically rely on mixed samples from large populations of cells, which can obscure cell heterogeneity, resulting in the loss of critical information. In contrast, single-cell sequencing immune cells overcomes this limitation. By sequencing individual cells, researchers can uncover the......
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• Single-Cell Sequencing Technology
Single-cell sequencing technology is an advanced genomic analysis approach designed for investigating the genome, transcriptome, and epigenome of individual cells. Traditional sequencing methods typically require large numbers of cells, and the resulting data represents averages across cell populations, thus failing to capture the specific differences of individual cells. However, organisms are composed of diverse cell types, each with its unique functions and gene expression profiles. Single-cell seq......
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• Single-Cell Sequencing from Frozen Tissue
Single-cell sequencing from frozen tissue is a biotechnology designed to deconstruct complex tissue samples to the single cell level and carry out comprehensive analyses, such as genomic and transcriptomic analyses. This technology is particularly well-suited for preserved tissue samples, allowing researchers to collect high-quality single cell data while maintaining sample integrity. The introduction of this technology has significantly advanced medical research, particularly in the areas of tumor he......
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Host cell protein assays are crucial techniques used to assess the residual amounts of exogenous proteins derived from production cells in biopharmaceutical products. These proteins may be inadvertently introduced during the manufacturing of biologics and can persist in the final product despite purification efforts. The presence of HCPs can compromise drug safety and efficacy, potentially triggering immune responses or interfering with the intended therapeutic functions. As such, host cell protein as......
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• Advancements in Targeted Drug Delivery Systems
Targeted drug delivery systems represent a crucial area in contemporary medical research, aimed at enhancing the precision and effectiveness of therapeutic interventions. Traditional drug delivery methods encounter challenges such as uneven drug distribution, limited drug half-life, and substantial side effects, which can restrict therapeutic efficacy and patient tolerance. Targeted drug delivery systems utilize specific carriers to precisely deliver drugs to affected sites, thereby increasing drug co......
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• Tandem Mass Spectrometry Protein Sequencing
Tandem mass spectrometry protein sequencing is a pivotal technique for determining the sequence and structural characteristics of protein molecules. By integrating liquid chromatography with mass spectrometry, it enables the identification and quantification of proteins within complex biological samples. The fundamental principle involves initially fragmenting protein samples into smaller peptides using a mass spectrometer, followed by further fragmentation of these peptides to glean detailed structur......
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Charge variant analysis is an important method in proteomics, primarily used to investigate the subtle structural variations of proteins and their impacts on biological function. As key molecules in life processes, the structure and charge state of proteins influence their physiological functions in organisms. During protein synthesis and post-translational modifications, various charge variants may arise. While these variants are nearly identical in amino acid sequence, they may differ in isoelectric......
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