Resources

Proteomics Databases



Metabolomics Databases

• • Biomarker Discovery Methods

  Biomarker discovery methods encompass a suite of technologies and strategies aimed at identifying and validating biomolecules indicative of specific biological states or disease conditions. These biomarkers may include genes, proteins, metabolites, or even cellular-level alterations. Biomarker discovery methods involve a broad range of techniques from genomics, proteomics, metabolomics, and bioinformatics. In genomics, frequently employed approaches include genome-wide association studies (GWAS) and .......

• • E. coli HCP Assay

  The E. coli HCP assay is a critical analytical procedure used for the qualitative and quantitative assessment of residual non-target proteins—i.e., host cell-derived impurities—within the E. coli expression system during recombinant protein production. This procedure plays a pivotal role in ensuring the safety, purity, and consistency of biopharmaceutical products. Due to its well-characterized genetics, rapid growth, and high protein expression yields, E. coli is widely employed as a host organism in......

• • Molecular Glue Screening

  Molecular glue screening is a systematic strategy for identifying or optimizing small molecules that can induce or enhance protein–protein interactions (PPIs). Unlike traditional inhibitors or agonists that typically act on a single target, molecular glues are a unique class of small molecules that function as “molecular bridges,” selectively facilitating the interaction between two proteins. This interaction can modulate cellular processes or even trigger the degradation of target proteins. By.........

• • Residual DNA Testing

  Residual DNA testing is an analytical approach used to quantify host cell-derived DNA present in biological products. This technique plays a critical role in the fields of biopharmaceuticals and biotechnology, primarily serving to evaluate whether residual host cell DNA levels exceed acceptable thresholds, thereby ensuring product safety and quality assurance. During the development and manufacturing of recombinant proteins, vaccines, monoclonal antibodies, as well as cell and gene therapy products.........

• • PFAS Mass Spectrometry

  PFAS mass spectrometry is a crucial analytical technique for detecting and quantifying the widespread presence of PFAS compounds in the environment. Owing to their unique chemical stability and extensive industrial and consumer applications, PFAS are often referred to as "forever chemicals," with detectable traces across environmental matrices, industrial processes, and consumer products. However, their extreme persistence and resistance to degradation pose significant environmental and public health ......

• • GC-MS Screening

  Gas chromatography–mass spectrometry (GC-MS) screening is an integrated analytical approach that combines gas chromatographic separation with mass spectrometric detection to identify and quantify compounds within complex sample matrices. Gas chromatography primarily serves to separate individual analytes present in a mixture, whereas mass spectrometry performs qualitative and quantitative analysis of the separated constituents. In the domain of environmental monitoring, GC-MS screening is extensively.......

• • Amino Acid Mass Spectrometry

  Amino acid mass spectrometry refers to analytical methods utilizing mass spectrometry to achieve highly sensitive and specific qualitative and quantitative analysis of amino acids and their derivatives. As the fundamental building blocks of proteins, amino acids play critical roles in various biological processes, including metabolism, signal transduction, and the pathogenesis of diseases. Amino acid mass spectrometry enables accurate profiling of amino acid composition and concentration changes in trace...

• • LCMS Proteomics

  LCMS proteomics represents a cutting-edge analytical platform for characterizing protein composition and abundance within complex biological matrices. This approach has broad utility in biomedical research, offering insights into disease mechanisms and enabling the discovery of candidate biomarkers that facilitate the development of personalized medicine. For instance, by profiling proteomic alterations in cancer patients, researchers can identify proteins associated with disease progression, thereby.......

• • Biomarker-Based Drug Development

  Biomarker-based drug development is a systematic approach that drives the discovery, validation, and clinical application of novel therapeutics through the identification and utilization of specific biomarkers. Biomarkers are typically defined as molecules or characteristics that objectively indicate physiological or pathological states within the body—such as proteins, nucleic acids, and metabolites—which are commonly found in biological samples including blood, urine, and tissue. The primary objective....

• • Tandem LC-MS

  Tandem Liquid Chromatography–Mass Spectrometry (LC-MS/MS) is a powerful analytical technique that integrates the separation efficiency of liquid chromatography (LC) with the sensitivity and specificity of tandem mass spectrometry (MS/MS). This method has been widely applied across diverse fields, including life sciences, pharmaceutical development, clinical diagnostics, environmental monitoring, and food safety. The core strength of Tandem LC-MS lies in its ability to first separate compounds in complex....