Peptidomics-Based Drug Discovery Service
- Tissues (e.g., liver, brain, kidney)
- Cultured cells (adherent or suspension)
- Biofluids (e.g., plasma, serum, cerebrospinal fluid)
- Tissues: ≥ 200 mg
- Biofluids: ≥ 200 µL
- Cells: ≥ 1 × 10⁷ cells per sample
- Samples should be stored at -80℃ and shipped with dry ice.
Peptides are short chains of amino acids, typically composed of 2 to 50 residues, that serve as crucial signaling molecules in a wide range of physiological processes. They regulate cellular communication, immune responses, metabolic balance, neurological activity, and more. Many therapeutic agents, such as insulin, glucagon, and oxytocin, are naturally occurring peptides or peptide mimetics, underscoring their importance in pharmacology. Peptidomics is the large-scale, high-throughput study of peptides. Unlike traditional proteomics, which focuses on full-length proteins, peptidomics specifically targets low-molecular-weight peptides that are either cleaved from larger precursors or independently synthesized.
Peptidomics-based drug discovery is an emerging research strategy that leverages the comprehensive analysis of peptides to identify new therapeutic agents, elucidate disease mechanisms, and support the development of targeted treatments. This approach integrates advanced mass spectrometry, computational analysis, and functional biology to systematically profile and characterize peptides in biological systems.
Service at MtoZ Biolabs
MtoZ Biolabs provides a comprehensive Peptidomics-Based Drug Discovery Service that integrates high-resolution mass spectrometry, robust peptide enrichment workflows, and AI-driven bioinformatics analysis. Our platform enables in-depth exploration of the peptidome from diverse sample types and conditions, empowering researchers and pharmaceutical developers to harness peptide information for translational innovation.
Our core capabilities include:
1. Peptide Identification and Characterization
We conduct high-throughput identification of peptides from diverse biological matrices. Our platform enables precise peptide sequencing, post-translational modification analysis, protease cleavage mapping, and structural elucidation—laying the foundation for drug candidate screening and mechanism studies.
2. Bioactivity Evaluation
We evaluate peptide bioactivity through a combination of in vitro and in vivo assays tailored to specific therapeutic goals. This includes antimicrobial testing, anti-inflammatory and antioxidant activity assays, cell proliferation or cytotoxicity studies, as well as animal-based functional evaluations. These experiments help confirm biological relevance, support mechanism-of-action studies, and guide peptide optimization for drug development.
3. Drug Development Support
We provide customized services for validating peptide biomarkers, studying peptide–target interactions, and monitoring peptide drug stability and quality. Our comprehensive datasets help refine lead compound selection, optimize formulation, and guide preclinical evaluation.
Peptidomics-Based Drug Discovery Solutions
Why Choose MtoZ Biolabs?
☑️Advanced Analysis Platform: MtoZ Biolabs established an advanced Peptidomics-Based Drug Discovery Service platform, guaranteeing reliable, fast, and highly accurate analysis service.
☑️Customized Research Support: Flexible experimental design, sample handling, and analysis depth tailored to your discovery goals.
☑️End-to-End Service: From peptide extraction to final interpretation, we provide a complete and reliable solution for peptidomics-driven research.
☑️One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.
Applications
1. Therapeutic Target Discovery
By profiling peptide expression patterns in physiological and pathological states, researchers can uncover novel peptide-based targets associated with disease onset, progression, or drug responsiveness.
2. Mechanism-of-Action Studies
Endogenous peptide signatures offer insight into the molecular mechanisms behind drug efficacy, resistance, or toxicity, supporting functional studies and drug repositioning.
3. Functional Peptide Screening
Our platform enables large-scale identification of peptides with antimicrobial, anti-inflammatory, immunomodulatory, or metabolic regulatory properties, facilitating early-stage screening of therapeutic candidates.
4. Peptide Biomarker Identification
Peptidomics helps discover disease-associated or treatment-responsive peptide biomarkers for patient stratification, drug efficacy monitoring, and personalized therapy development.
5. Off-Target Effect Analysis
Comprehensive profiling of unintended peptide responses can reveal off-target interactions, aiding in preclinical safety assessment and toxicity risk reduction.
6. Drug Side Effect Mechanism Elucidation
We assist in investigating the peptidomic basis of drug-induced adverse reactions, helping clients understand and mitigate side effects at the molecular level.
7. Quality Control of Peptide Drugs
Peptidomics ensures the batch-to-batch consistency, purity, and structural integrity of peptide-based therapeutics, playing a critical role in process validation and regulatory submission.
8. Support for Prodrug and Delivery System Design
Analysis of cleavage sites, peptide stability, and metabolic conversion guides the rational design of prodrugs or peptide-based delivery strategies with improved pharmacokinetics.
Sample Submission Suggestions
1. Sample Types
We accept various sample types, including but not limited to:
2. Sample Quantity
3. Storage and Transport
*Note: If you have special sample types or require additional guidance, please contact us for personalized support before shipping.
Deliverables
1. Comprehensive Experimental Details
2. Materials, Instruments, and Methods
3. Total Ion Chromatogram & Quality Control Assessment
4. Data Analysis, Preprocessing, and Estimation
5. Bioinformatics Analysis
6. Raw Data Files
Related Services
Peptide Mass Spectrometric Identification Service
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