Peptidomics-Based Drug Target Research Service
- Tissues (e.g., liver, brain, kidney)
- Cultured cells (adherent or suspension)
- Biofluids (e.g., plasma, serum, cerebrospinal fluid)
- Tissues: ≥ 200 mg
- Biofluids: ≥ 200 µL
- Cells: ≥ 1 × 10⁷ cells per sample
- Samples should be stored at -80℃ and shipped with dry ice.
The identification and validation of drug targets are fundamental to the development of effective therapeutics. Traditional target discovery approaches, such as genomics, transcriptomics, and proteomics, provide valuable information about potential targets. However, these methods often fail to capture the full complexity of proteolytic regulation, post-translational processing, and functional peptide signaling. Peptidomics, the large-scale study of endogenous peptides, offers a powerful and complementary perspective that reveals biologically active peptides and their associated precursor proteins, protease networks, and disease-related cleavage events.
Peptidomics focuses on low-molecular-weight peptides naturally present in cells, tissues, and biofluids. These peptides serve as functional messengers, enzymatic substrates, or degradation products that reflect the physiological and pathological state of a biological system. By profiling peptide changes in response to drug treatment or disease progression, researchers can uncover novel targets, monitor protease activity, and explore peptide–receptor interactions critical for therapeutic intervention.
Service at MtoZ Biolabs
MtoZ Biolabs provides a comprehensive Peptidomics-Based Drug Target Research Service that integrates high-resolution LC-MS/MS, advanced enrichment techniques, and custom bioinformatics pipelines. Our platform enables deep peptidome profiling across a variety of sample types and experimental models, delivering actionable insights for target identification, functional validation, and early-stage drug discovery.
MtoZ Biolabs helps clients achieve the following:
💠Identification of Novel Drug Targets
Our peptidomics platform enables the identification of previously unrecognized bioactive peptides and their associated precursor proteins. By profiling the peptidome in disease models, we help pinpoint new drug targets that could be leveraged for therapeutic intervention.
💠Disease Mechanism Research
We assist in unraveling the complex molecular mechanisms underlying diseases by analyzing peptide-level changes in response to drug treatments. This insight aids in understanding how drugs modulate disease pathways at the molecular level, uncovering key regulatory peptides involved in disease progression.
💠Drug Repurposing
By profiling the peptidome of drug-treated cells or tissues, we identify unexpected peptide responses that could suggest new uses for existing drugs. This service helps to uncover alternative therapeutic applications for established compounds.
💠Peptide-Based Therapeutic Development
MtoZ Biolabs supports the development of peptide-based therapeutics by identifying bioactive peptides that can serve as drug candidates. Our service helps in screening and validating peptide candidates that could potentially be developed into targeted therapies for specific diseases.
💠Drug Resistance Research
Through the study of peptide alterations in response to drug treatments, we support research into drug resistance mechanisms. This includes identifying resistance-associated peptides and understanding how bacteria or cancer cells evade drug efficacy, offering new avenues for combatting resistance.
Analysis Workflow
1. Sample Preparation
Biological samples are processed using enzyme-free extraction to enrich endogenous peptides.
2. Peptide Purification
Peptides are desalted and fractionated using SPE or high-pH RPLC to reduce complexity and improve detection.
3. LC-MS/MS Analysis
Peptides are analyzed using high-resolution LC-MS/MS platforms to ensure accurate mass detection and fragmentation for precise peptide identification and characterization.
4. Database Search
MS data are searched against curated protein databases to identify peptide sequences and origins.
5. Bioinformatics-Based Target Discovery
Identified peptides are quantitatively analyzed across experimental groups. Statistical and clustering analyses are used to highlight differentially expressed peptides. Integrated functional annotation, pathway enrichment, and peptide-protein interaction mapping are performed to infer putative drug targets.
6. Validation and Functional Interpretation
Candidate targets are cross-validated using external databases and literature mining. Peptides related to known or novel disease mechanisms are prioritized for follow-up studies or functional assays.
7. Custom Reporting
Comprehensive analysis reports include peptide profiles, quantitative results, target candidates, interaction networks, and mechanistic interpretations tailored to the client's research focus and therapeutic interests.
Why Choose MtoZ Biolabs?
✅High-Quality Results: Advanced Peptidomics-Based Drug Target Research Service platform ensures reliable and highly accurate data.
✅Specialized in Peptidomics: Deep expertise in peptide analysis for drug target discovery.
✅Flexible Project Design: Custom workflows tailored to specific research needs.
✅Fast Turnaround Time: Efficient workflow to accelerate your research timeline.
✅Transparent Pricing: One-time charge with no hidden fees.
Sample Submission Suggestions
1. Sample Types
We accept various sample types, including but not limited to:
2. Sample Quantity
3. Storage and Transport
*Note: If you have special sample types or require additional guidance, please contact us for personalized support before shipping.
Deliverables
1. Comprehensive Experimental Details
2. Materials, Instruments, and Methods
3. Total Ion Chromatogram & Quality Control Assessment
4. Data Analysis, Preprocessing, and Estimation
5. Bioinformatics Analysis
6. Raw Data Files
To learn more about our Peptidomics-Based Drug Target Research Service, please contact us. Our team of experts is ready to provide customized solutions for your drug development needs.
Related Services
Drug Target Identification and Validation Services
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