Peptidomics-Based Drug Off-Target Effects Research Service
- Tissues (e.g., liver, brain, kidney)
- Cultured cells (adherent or suspension)
- Biofluids (e.g., plasma, serum, cerebrospinal fluid)
- Tissues: ≥ 200 mg
- Biofluids: ≥ 200 µL
- Cells: ≥ 1 × 10⁷ cells per sample
- Samples should be stored at -80℃ and shipped with dry ice.
Off-target effects are a major concern in drug development, often leading to reduced therapeutic efficacy, unexpected toxicity, and clinical failure. These unintended biological interactions occur when a drug interacts with proteins, receptors, or signaling pathways other than its intended target. Understanding and mitigating off-target effects is crucial for improving drug safety, optimizing dosing strategies, and meeting regulatory expectations.
Peptidomics, the large-scale analysis of endogenous peptides, offers a powerful strategy for uncovering the molecular consequences of drug treatment beyond primary target engagement. As peptides are directly involved in numerous biological functions including signaling, metabolism, immune responses, and stress regulation, changes in their abundance and modification status can reveal subtle yet significant alterations in physiological pathways caused by off-target drug interactions.
Service at MtoZ Biolabs
MtoZ Biolabs offers a specialized Peptidomics-Based Drug Off-Target Effects Research Service to support pharmaceutical and biomedical research. Our Peptidomics-Based Drug Off-Target Effects Research Service platform combines advanced mass spectrometry, precise sample preparation, and robust bioinformatics to provide in-depth characterization of peptide-level changes in response to drug exposure. By analyzing drug-induced alterations in peptide expression and post-translational modifications, we help researchers identify unintended biological effects, evaluate drug specificity, and refine compound selection during preclinical and clinical development.
To uncover the full spectrum of off-target responses, we provide the following complementary analyses:
💠Protein–Protein Interaction Analysis
We study changes in protein–protein interaction networks influenced by drug treatment, helping identify indirect targets and affected cellular processes.
💠Proteome Expression Profiling
Comprehensive profiling of global protein expression levels to assess how drug exposure alters the proteome beyond peptide-level changes.
💠Post-Translational Modification (PTM) Analysis
Investigation of drug-induced alterations in key modifications such as phosphorylation, acetylation, and oxidation, which often mediate off-target effects.
💠Signal Pathway Analysis
Mapping of altered peptides and proteins to signaling pathways to interpret functional consequences and identify unintended biological activations.
Service Advantages
✔️Advanced Analysis Platform
MtoZ Biolabs established an advanced Peptidomics-Based Drug Off-Target Effects Research Service platform, guaranteeing reliable, fast, and highly accurate analysis service.
✔️Customizable and Scalable Solutions
Whether for early screening or in-depth mechanistic studies, our workflows are adaptable to different sample types, drug classes, and research objectives.
✔️Regulatory and Translational Value
Our data support both internal R&D and regulatory submissions by providing robust, mechanistically grounded evidence of drug specificity, safety, and biomarker relevance.
✔️One-Time-Charge
Our pricing is transparent, no hidden fees or additional costs.
Applications
1. Preclinical Drug Safety Evaluation: Peptidomics reveals early molecular changes associated with toxicity, helping to identify unintended off-target effects before clinical manifestation, thus enhancing preclinical safety evaluation.
2. Therapeutic Efficacy Optimization: By monitoring peptide-level responses to treatment, our service helps refine drug dosage and timing, improving therapeutic precision and minimizing adverse effects.
3. Target Identification and Validation: Peptidomic changes can highlight previously unrecognized biological pathways or protein interactions affected by a compound, aiding in the identification of novel or secondary drug targets.
4. Biomarker Discovery: Endogenous peptides altered by drug exposure may serve as sensitive biomarkers for off-target activity, treatment response, or toxicity, supporting both clinical monitoring and companion diagnostics.
Sample Submission Suggestions
1. Sample Types
We accept various sample types, including but not limited to:
2. Sample Quantity
3. Storage and Transport
*Note: If you have special sample types or require additional guidance, please contact us for personalized support before shipping.
Deliverables
1. Comprehensive Experimental Details
2. Materials, Instruments, and Methods
3. Total Ion Chromatogram & Quality Control Assessment (project-dependent)
4. Data Analysis, Preprocessing, and Estimation (project-dependent)
5. Bioinformatics Analysis
6. Raw Data Files
MtoZ Biolabs is your trusted partner for advanced peptidomics research. Our Peptidomics-Based Drug Off-Target Effects Research Service is designed to help you uncover hidden biological responses to drug treatment, reduce development risk, and refine therapeutic strategies. Contact us to discuss your project needs and receive expert support tailored to your research goals.
Related Services
Peptide Mass Spectrometric Identification Service
How to order?
