Qualitative Peptidomics Service
- Disease Mechanism Research
- Biomarker Discovery
- Signal Pathway Studies
- Drug Target Validation
- Food and Nutrition Research
Qualitative Peptidomics Service aims to comprehensively identify and structurally analyze endogenous peptides in biological samples. This service focuses on sequence recognition, molecular mass determination, identification of post-translational modifications (such as phosphorylation, methylation, glycosylation, etc.) of peptides, and the discovery of potential functional peptides or disease markers. It is widely used in the fields of mechanism research, drug development, and disease biomarker screening.
Peptidomics is a cutting-edge branch of proteomics, focusing on systematically identifying and analyzing the distribution, structure, and function of endogenous peptides in biological systems. Compared with intact proteins, peptides have small molecular weights, flexible structures, and complex modifications. They play a key role in multiple physiological processes such as cell signal transduction, hormone regulation, immune response, and metabolic regulation. At the same time, peptides are often used as disease biomarkers, drug candidate molecules, or metabolic intermediates, and have received extensive attention in the clinical and drug development fields. As the basic direction of peptidomics research, Qualitative Peptidomics is committed to systematically revealing the identity, structure, post-translational modifications (PTMs) and variation characteristics of peptides in biological samples.
Services at MtoZ Biolabs
Leveraging high-resolution mass spectrometry and other advanced platforms, MtoZ Biolabs offers a comprehensive and customizable Qualitative Peptidomics Service covering peptide identification, sequence determination, structural analysis, and post-translational modification profiling. This service is designed to support researchers in efficiently exploring peptide-level functions and conducting in-depth mechanistic studies.
Chromatography and mass spectrometry are used to assess peptide purity in samples, ensuring the reliability of downstream experiments and providing a solid foundation for drug development and formulation quality control.
Peptide Molecular Mass Determination
High-resolution mass spectrometry is used to accurately determine the molecular weight of peptides, providing a fundamental basis for subsequent identification and purity assessment.
Peptide Mass Spectrometric Identification
Through the high-resolution mass spectrometry platform combined with database comparison and algorithm recognition, peptides can be quickly screened and identified, which is suitable for the preliminary identification of functional peptides in complex samples and the verification of known peptides.
Peptide amino acid sequences can be analyzed using Edman degradation or mass spectrometry, enabling N-terminal sequencing, C-terminal sequencing, and full-length sequence determination.
Peptide Post-Translational Modification Identification
For modifications such as phosphorylation, methylation, acetylation, and glycosylation, specialized enrichment strategies combined with mass spectrometry are employed to accurately identify modification sites and uncover underlying regulatory mechanisms.
Circular dichroism (CD) and nuclear magnetic resonance (NMR) are used to analyze the secondary and tertiary structures of peptides, supporting studies on structure–activity relationships.
Peptide Biomarker Identification
By comparing peptide profile differences under various physiological or pathological conditions and integrating statistical and bioinformatics approaches, potential diagnostic or prognostic biomarkers can be identified.
Schrader M. et al. Eupa Open Proteomics. 2014.
Figure 1. General methods of peptidomics.
Service Advantages
Advanced Analysis Platform: MtoZ Biolabs established an advanced Qualitative Peptidomics Service platform, guaranteeing reliable, fast, and highly accurate analysis service.
One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.
High-Data-Quality: Deep data coverage with strict data quality control. AI-powered bioinformatics platform integrates all Qualitative Peptidomics data, providing clients with a comprehensive data report.
Comprehensive Coverage of Multidimensional Peptide Analysis: Our service portfolio encompasses molecular weight determination, sequence identification, structural analysis, purity assessment, biomarker discovery, and post-translational modification profiling, meeting diverse needs from basic research to applied development.
Customized Service Support: Tailored experimental designs and bioinformatics solutions are available based on the client's research objectives and sample types.
Sample Submission Suggestions
Sample Types: Accepts samples including cells, tissues, body fluids, and synthetic peptide mixtures.
Storage and Transportation: Store at low temperatures (−20°C or −80°C). Dry ice transportation is recommended to avoid repeated freeze-thaw cycles.
Additional Notes: We recommend contacting us prior to sample submission for detailed and tailored sample preparation guidelines.
Applications
Qualitative Peptidomics Service has broad application value across multiple areas of life science research, including but not limited to:
By analyzing differences in the peptidome between pathological and normal states, this service helps reveal the molecular mechanisms underlying diseases.
Identifies characteristic endogenous peptides with diagnostic or prognostic value, supporting the development of clinical detection tools.
Explores changes in bioactive peptides under physiological or stress conditions to understand their regulatory roles in signal transduction.
Detects functional peptides and their post-translational modifications, providing a basis for peptide drug screening and mechanism-of-action studies.
Analyzes the composition of food-derived bioactive peptides to evaluate nutritional and physiological effects in the development of functional foods.
Related Services
Peptide Sample Preparation Service
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