Targeted Mass Spectrometry-Based Quantitative Neuropeptidomics Service

Neuropeptides are important signaling molecules in the nervous system, playing a crucial role in neurotransmission, regulation, and intercellular signaling. Quantifying neuropeptides can reveal their dynamic changes under various physiological and pathological conditions, helping to deepen the understanding of the functioning of the nervous system, disease mechanisms, and potential drug targets. This provides essential biomarkers and data support for neuroscience and clinical research. However, the low abundance of neuropeptides, complex sample matrix interference, and their diverse structural features make precise and sensitive quantification challenging.

 

Utilizing advanced mass spectrometry technology, MtoZ Biolabs offers the Targeted Mass Spectrometry-Based Quantitative Neuropeptidomics Service for researchers in neuroscience, clinical research, and drug development, aiding in exploring the biological functions and mechanisms of neuropeptides.

 

Services at MtoZ Biolabs

MtoZ Biolabs' targeted mass spectrometry-based quantitative neuropeptidomics service employs state-of-the-art liquid chromatography-tandem mass spectrometry (LC-MS/MS) technology combined with targeted analysis strategies such as PRM or MRM to precisely measure the content and structural characteristics of neuropeptides. Targeted mass spectrometry technology offers unparalleled advantages in neuropeptide quantification, providing both high sensitivity and selectivity for detection.

 

Our service not only supports the quantitative analysis of neuropeptides but also includes their qualitative identification and functional research. By accurately measuring the changes in neuropeptide levels in biological samples, we provide comprehensive data support that can reveal dynamic changes in neuropeptides under various physiological and pathological conditions, driving deeper insights into neuroscience research and disease mechanisms.

 

Analysis Workflow

 



 

Service Advantages

1. High Sensitivity and High Precision

With advanced targeted mass spectrometry technology (Thermo Fisher Orbitrap series, Q Exactive, etc.), we can detect neuropeptides at extremely low concentrations and provide accurate quantitative results. Even in complex biological samples, we ensure precise neuropeptide quantification, minimizing interference from sample impurities.

 

2. Flexible Sample Type Support

MtoZ Biolabs' Targeted Mass Spectrometry-Based Quantitative Neuropeptidomics Service supports a wide range of sample types, including but not limited to cerebrospinal fluid, brain tissue, serum, urine, etc. Whether clinical samples or lab-created samples, we provide flexible solutions to meet the needs of various clients.

 

3. Highly Customized Service

We provide tailor-made Targeted Mass Spectrometry-Based Quantitative Neuropeptidomics Service according to client requirements, from sample preparation to the design of analysis protocols, ensuring that the specific needs of neuropeptide research are met.

 

4. Professional Team Support

Our team consists of experienced scientists and engineers with years of mass spectrometry analysis experience and neuropeptidomics research background. Clients can receive professional technical support and consultation, ensuring the scientific and accurate design of experimental protocols.

 

5. Support for Multiple Quantification Methods

We offer a variety of quantification methods, including Isobaric Labeling quantification techniques (such as TMT, iTRAQ, and SILAC) and Label-Free quantification. These methods can be selected based on the specific needs of the experiment, ensuring efficient and precise quantification results under different experimental conditions.

 

Applications

1. Neurodegenerative Disease Research

Neuropeptides play an important role in many neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and depression. By quantitatively analyzing these neuropeptides, we provide data support for early diagnosis, pathology research, and drug development.

 

2. Drug Development and Screening

In the drug development process, neuropeptides are one of the drug targets. We help pharmaceutical companies assess the impact of candidate drugs on neuropeptides, providing early data support for clinical trials.

 

3. Basic Neuroscience Research

Through targeted mass spectrometry-based quantitative analysis of neuropeptides, we can study their roles in neural signal transmission, memory, emotional regulation, and more, providing essential data for basic neuroscience research.

 

FAQs

1. How long does the experimental cycle for Targeted Mass Spectrometry-Based Quantitative Neuropeptidomics Service typically take?

The experimental cycle for neuropeptide quantification typically takes 2 to 4 weeks. The exact time depends on sample type, experimental design, and the complexity of data processing. After receiving the samples, we will provide a detailed time estimate based on the specific requirements of the experiment.

 

Sample Submission Suggestions

1. Sample Types: Serum, cerebrospinal fluid, urine, brain tissue, cell culture supernatant, etc.

2. Sample Volume: We recommend submitting 5-100 µL of sample depending on the sample type, with specific requirements based on the experimental design.

3. Storage Conditions: Samples should be stored at -80°C to avoid repeated freeze-thaw cycles.

 

Deliverables

1. Quantitative Analysis Report: Detailed quantification results of neuropeptides, including statistical analysis and data visualization charts.

2. Raw Data Files: We provide the original mass spectrometry data files, allowing clients to conduct further analysis if needed.

3. Data Interpretation: Professional technical reports and data interpretation to help clients understand the experimental results.

 

MtoZ Biolabs, with advanced targeted mass spectrometry technology and extensive neuropeptidomics research experience, offers comprehensive and accurate Targeted Mass Spectrometry-Based Quantitative Neuropeptidomics Service. Whether you are engaged in basic research, drug development, or disease mechanism research, we can provide powerful data support.

 

If you are looking for high-quality quantitative neuropeptidomics service, please contact us immediately, and we will provide the most professional support for your research.

 

Related Services

Untargeted Mass Spectrometry-Based Quantitative Neuropeptidomics Service