PTM Service
Post-translational modifications (PTMs) are covalent chemical changes that occur on proteins after translation, fundamentally regulating protein activity, stability, localization, and interactions. These modifications extend the functional diversity of the proteome and are central to the dynamic control of nearly every cellular process. PTMs such as phosphorylation, ubiquitination, acetylation, glycosylation, methylation, and SUMOylation influence key biological events including signal transduction, gene expression, cell cycle progression, DNA repair, and apoptosis.
Heitel, P. Molecules. 2023.
Because of their critical roles in health and disease, comprehensive PTM analysis has become an essential component in molecular biology, biomedical research, and biopharmaceutical development. Detailed characterization of PTMs supports the discovery of therapeutic targets, elucidates disease mechanisms, and provides biomarkers for early diagnosis and prognosis. In drug development, PTM profiling assists in quality control and functional evaluation of therapeutic proteins, monoclonal antibodies, and biosimilars.
Service at MtoZ Biolabs
MtoZ Biolabs offers a comprehensive PTM Service tailored to meet the growing demand for accurate and reproducible PTM characterization in both basic research and applied settings. Leveraging our advanced mass spectrometry platforms including Thermo Scientific Orbitrap Fusion Lumos and Q Exactive HF, along with high-resolution nanoLC systems, we enable full-spectrum PTM detection and quantification with site-level precision.
To meet a wide range of scientific needs, MtoZ Biolabs has developed a modular PTM services platform that covers multiple dimensions of PTM analysis. Our integrated service portfolio includes qualitative and quantitative profiling, PTM site mapping, functional correlation studies, and global modification network assessments. Furthermore, our expertise extends to histone modifications, which are crucial epigenetic regulators. We provide deep coverage and high-accuracy identification and quantification of histone PTMs.
Why Choose MtoZ Biolabs?
✔️Advanced Analysis Platform
MtoZ Biolabs established an advanced PTM Service platform, guaranteeing reliable, fast, and highly accurate analysis service.
✔️High-Data-Quality
Deep data coverage with strict data quality control. AI-powered bioinformatics platform integrates all proteomics analysis data, providing clients with a comprehensive data report.
✔️Comprehensive Detection of Multiple PTM Types
We offer enrichment and detection services for various post-translational modifications, including phosphorylation, acetylation, methylation, ubiquitination, glycosylation, and nitration, facilitating the analysis of complex biological regulatory mechanisms.
✔️Customized Services
MtoZ Biolabs provides personalized experimental design and data analysis tailored to diverse research needs, covering disease studies, target screening, biomarker discovery, and immune regulation, thereby advancing precision medicine research.
✔️One-Time-Charge
Our pricing is transparent, no hidden fees or additional costs.
Applications
1️⃣Disease Mechanism Research
By analyzing PTM patterns, this approach reveals key regulatory mechanisms underlying cancer, neurodegenerative diseases, cardiovascular diseases, and autoimmune disorders, aiding in early disease diagnosis and targeted therapy.
2️⃣Biomarker Discovery
PTM Service enables comparative analysis of modified proteins in healthy and diseased samples, identifying PTM biomarkers associated with diseases and providing potential biomarkers for precision medicine.
3️⃣Drug Target Screening and Mechanism of Action Studies
PTM analysis helps decipher how drugs influence protein modification states, facilitating the identification of potential drug targets, evaluating drug mechanisms and efficacy, and optimizing novel drug development strategies.
4️⃣Cell Signaling Pathway Research
By quantitatively analyzing phosphorylation, acetylation, ubiquitination, and other modifications, this approach reveals the role of proteins in signal transduction, metabolic regulation, and cell cycle control, contributing to fundamental life sciences research.
5️⃣Immunology Research
Analyzing PTMs of immune-related proteins helps explore their functions in immune responses, inflammatory reactions, and the tumor immune microenvironment, providing valuable data for immunotherapy development.
6️⃣Biopharmaceutical Development and Quality Control
PTM service can be used to monitor PTM patterns in antibody drugs, vaccines, and protein-based therapeutics, ensuring the stability and consistency of biopharmaceutical products while improving their quality and safety.
Sample Submission Suggestions
We accept, but are not limited to, the following sample types: cell lysates, tissues, serum, plasma, CSF, and purified protein complexes. Different PTM analysis workflows may require specific sample preparation conditions and submission quantities.
To ensure optimal results, we strongly recommend consulting our technical team prior to sample preparation. We will provide a customized sample submission protocol tailored to your research objectives and sample characteristics.
Deliverables
1. Comprehensive Experimental Details
2. Materials, Instruments, and Methods
3. Total Ion Chromatogram & Quality Control Assessment
4. Data Analysis, Preprocessing, and Estimation
5. Bioinformatics Analysis
6. Raw Data Files
If you are exploring PTM dynamics, validating therapeutic proteins, or investigating disease-related modifications, MtoZ Biolabs is your trusted partner for accurate, insightful, and publication-ready results. Contact us today to discuss your project and receive a tailored service proposal.
How to order?
