High-Throughput Antibody Glycans Screening Service
High-throughput antibody glycans screening is a screening method based on high-throughput technology, capable of rapidly selecting antibodies with specific glycan structures. The glycosylation modifications of antibodies play a key role in their structural stability, half-life, effector functions, and immune regulation. Through high-throughput screening methods, large numbers of glycan structures can be rapidly screened to identify candidate antibodies with high affinity for glycan antigens, thus enabling the fast identification of antibodies with specific glycan structures, which play important roles in drug development and therapy.
The high-throughput antibody glycans screening service has important applications in multiple fields. In the antibody drug development stage, it can quickly screen candidate antibodies with specific glycan modifications. During production, it allows for the monitoring of the consistency and batch stability of antibody glycosylation modifications. In quality control and testing, high-throughput screening can be used to identify potential glycan variations. Additionally, this service can also be applied to basic research, such as exploring the role of glycan modifications in antibody functional regulation and immune response, providing a powerful tool for antibody engineering and glycomics research.
Primack, J. et al. Microfluidics and Miniaturization, 2011.
Figure 1. Overlay of the N-glycan Profiles of Purified IgG1 and IgG2 mAbs.
Services at MtoZ Biolabs
Based on a high-throughput screening platform, MtoZ Biolabs offers the high-throughput antibody glycans screening service for rapid and systematic analysis and screening of glycan modifications on antibodies. This service relies on a microchip array detection system and high-resolution mass spectrometry (LC-MS/MS) platform, enabling high-throughput detection of the binding characteristics of antibodies to specific glycan structures, thereby selecting antibodies with particular glycan structures. Through this service, researchers can efficiently screen high-affinity candidate antibodies in a short period, providing reliable data support for antibody function research, structural optimization, and biologics quality control.
Sample Submission Suggestions
1. Sample Type
Suitable for antibody samples with glycan modifications, including monoclonal antibodies, polyclonal antibodies, and recombinant antibodies. Samples should have a clear source and be free from contaminating impurities.
2. Sample Purity
It is recommended that the sample purity be no less than 90%, with serum proteins, lipids, or other impurities removed, to ensure the accuracy of the screening results.
3. Sample Storage and Transportation
Samples should be stored and transported at low temperatures. Liquid samples should be transported with ice packs or dry ice, while lyophilized powder samples should be sealed and protected from moisture. The entire transportation process should maintain a low temperature to ensure the stability of the samples.
Service Advantages
1. High-Throughput Screening Capability
Relying on an advanced high-throughput detection platform, large-scale antibody screening can be completed in a short time, significantly improving research efficiency.
2. Diverse Screening Methods
Combining microarray chips and mass spectrometry platforms with other detection methods, the service flexibly adapts to different experimental needs, ensuring comprehensive and reliable screening results.
3. Customized Solutions
Personalized screening plans are provided based on the client's research goals and antibody characteristics, meeting the needs at various stages of research and development.
4. One-Stop Service
From sample preparation and screening to data analysis and report generation, a complete one-stop service is provided, simplifying workflows and enhancing efficiency.
Applications
1. Antibody Function Research
The high-throughput antibody glycans screening service can be used to screen antibodies with high affinity for specific glycan structures, revealing their roles in molecular recognition and signal regulation.
2. Antibody Drug Development
In the drug development process, this service helps to quickly identify candidate antibodies, improving targeting and functional optimization efficiency.
3. Biopharmaceutical Quality Monitoring
During antibody production and optimization, this service monitors the stability of glycan modifications, ensuring product quality consistency.
4. Basic Research Exploration
The high-throughput antibody glycans screening service can be applied in immunology, cell biology, and other fields to support research on the mechanisms of antibody-glycan interactions.
FAQ
Q1: Can This Service Be Used to Discover Novel Antibodies?
A1: Yes. Through large-scale parallel screening, this service can quickly identify new candidate antibodies, supporting drug development and functional antibody research.
Q2: Does the Sample Have a Significant Impact on the Experimental Results?
A2: Yes. Samples must maintain high purity and integrity to avoid interference from impurities, ensuring the accuracy and reproducibility of the screening results.
Q3: Is this Service Suitable for Large-Scale Screening?
A3: Yes. The high-throughput platform allows for large-scale screening analysis, significantly improving research and development efficiency.
Related Services
High-Throughput Glycan Screening Service
High-Throughput N-Glycan Screening Service
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