Exosome Engineering
- Targeted Drug Delivery: Deliver chemotherapeutics, peptides, or small molecules to specific tissues or cells
- Gene Therapy: Transport mRNA, siRNA, or miRNA for gene modulation
- Cancer Immunotherapy: Display tumor antigens or immunostimulatory molecules for vaccine development
- Regenerative Medicine: Promote tissue repair via targeted exosome delivery
- Isolated Exosomes: ≥200 μg total protein or ≥100 μL in PBS
- Plasma/Serum: ≥2 mL per sample
- Cell Culture Supernatants: ≥5 mL per sample
- Other Body Fluids: Please inquire for specific requirements
Exosome Engineering is a technology that involves the modification of exosomes to enhance their applications in cell therapy, drug delivery, and immune regulation. Exosomes are nano-sized vesicles secreted by cells, widely present in various body fluids, and naturally carry molecules such as proteins, RNA, and lipids, which allow them to effectively participate in intercellular communication. By engineering the surface, contents, and biological properties of exosomes, they can be endowed with stronger targeting abilities, higher drug-loading capacities, or enhanced therapeutic effects in specific diseases.
Exosome engineering service has broad applications in cancer treatment, gene therapy, immunotherapy, and neurodegenerative diseases, among other fields. For example, in cancer treatment, engineered exosomes can serve as drug carriers, precisely targeting tumor cells; in immunotherapy, exosomes can carry antigens or immune-modulating factors to enhance immune responses. Through engineering modifications of exosomes, their delivery efficiency can be improved, and toxicity reactions can be reduced, thereby holding immense potential for clinical therapies.
Sadeghi, S. et al. Inflammopharmacology, 2023.
Figure 1. Summary of the Engineering Modification of Exosomes
Services at MtoZ Biolabs
Based on advanced technology and analysis platforms, the exosome engineering service provided by MtoZ Biolabs can engineer exosomes to ensure optimization in terms of targeting, loading capacity, and biocompatibility. The service includes exosome modification, surface labeling, functional molecule loading, and provides detailed functional evaluation and targeting analysis data. By modifying the surface and adjusting the content of exosomes, their functionality is enhanced in cell therapy, drug delivery, and immune regulation.
Service Advantages
✔️Customizable Modification Strategies
Flexible surface functionalization and cargo-loading methods tailored to specific applications, targets, and delivery routes.
✔️Rigorous Quality Control
Each batch of engineered exosomes undergoes strict QC, including size distribution, marker validation, and loading efficiency assessments.
✔️Multi-Omics Integration
Support for proteomics, transcriptomics, lipidomics, and metabolomics to validate exosome functionality and composition.
✔️One-Time-Charge
Our pricing is transparent, no hidden fees or additional costs.
✔️High Safety and Biocompatibility
Engineered exosomes exhibit excellent biocompatibility and low immunogenicity, ensuring their safety when used in vivo.
Applications
Engineered exosomes have broad and expanding applications:
Sample Submission Suggestions
We accept the following sample types:
Samples should be stored at -80°C and shipped on dry ice. Avoid repeated freeze–thaw cycles. Pre-consultation is encouraged for custom design.
Deliverables
1. Purified engineered exosomes (optional delivery formats: lyophilized or in suspension)
2. Detailed technical report covering engineering strategy, methodology, QC results, and storage instructions
3. Supporting raw data from characterization assays (e.g., Western blot, NTA, LC-MS/MS)
4. Optional: downstream omics data, functional assay results, or scale-up documentation based on request
Exosome engineering is transforming the landscape of targeted therapy, diagnostics, and precision medicine. MtoZ Biolabs is committed to supporting innovation through high-quality, customizable exosome engineering services that meet the demands of modern biomedical research. Contact us today to discuss your project and request a customized proposal!
How to order?
