Resources

Proteomics Databases



Metabolomics Databases

• • Neutrophil Proteomics

  Neutrophil proteomics is the field of study that examines the composition and function of proteins within neutrophils (a type of white blood cell, also known as a type of leukocyte). Neutrophils are part of the immune system, playing a crucial role in eliminating infections and inflammation. By studying the proteome of neutrophils, we can gain deeper insight into their role in immune response, inflammation regulation, and disease progression. The research content of neutrophil proteomics includes:

• • Quantitative Proteomics Labeling

  With the advancement of proteomics, qualitative analysis of protein types and modifications alone can no longer meet research needs. In this context, quantitative proteomics technology has emerged and has become one of the hot topics in life sciences in recent years. The quantification technology of proteomics is based on the known protein type, and quantifies its expression and abundance based on the signal intensity given by mass spectrometry. It can be divided into targeted and non-targeted.

• • Unlabeled Quantitative Proteomics

  Label-free Quantitative Technology is one of the methods for studying quantitative proteomics. Compared to traditional labeling quantitative methods, label-free quantitative protein technology has significant advantages. Traditional labeling methods usually involve complex experimental steps, which are time-consuming and laborious, and the cost of labeling reagents is high.

• • What Is the Recombination of Type III Collagen?

  Recombinant Type III Collagen is a type of collagen protein produced through biotechnological methods. In nature, collagen is a vital structural protein, widely present in the skin, bones, tendons, and other connective tissues of humans and animals. Type III collagen is particularly common in newly formed connective tissues and rapidly growing tissues, such as during the wound healing process.

• • Qualitative Detection of Recombinant Human Collagen Protein

  Collagen, as one of the most abundant proteins in the human body, plays a key role in maintaining the integrity and function of tissue structures. With the development of bioengineering technology, recombinant human collagen (rhCollagen) produced by recombinant DNA technology has been widely applied in various fields such as medicine, cosmetics, and tissue engineering.

• • T Cell Antigen Receptor Sequencing

  The T cell antigen receptor (TCR) is a characteristic marker of T cells, playing a crucial role in the immune system. Each T cell typically expresses a specific TCR, which has a unique structure and sequence that can recognize different antigens, including bacteria, viruses, tumor cells, and other pathogens. Once the TCR binds to the antigen, the T cell initiates an immune response, generating cytotoxic effects, secreting cytokines, and coordinating the activities of other immune cells.

• • Protein Phosphorylation Mass Spectrometry Analysis

  Protein phosphorylation is a type of post-translational modification catalyzed by protein kinases and phosphatases (PP), playing crucial roles in many cellular processes including the cell cycle, growth, apoptosis, and signal transduction pathways. To understand these mechanisms, it is essential to analyze protein phosphorylation. There are many methods for phosphorylation analysis, including kinase activity assays, development of phosphorylation-specific antibodies, protein blotting

• • Chemistry Proteomics

  Chemical proteomics is one of the important approaches in chemical biology research. It differs from traditional proteomics techniques that focus on qualitative or quantitative identification of proteins. Chemical proteomics aims to investigate the interactions between proteins in complex systems such as cell lysates, live cells, and tissues, and small molecule drugs using a variety of functional chemical probes in combination with proteomics techniques.

• • Detection of Binding Activity of Antibody Drugs

  The evaluation of binding activity of antibody drugs (such as monoclonal antibodies) is a key step in ensuring their efficacy and safety in the drug development and quality control process. Binding activity refers to the ability of an antibody to bind to its specific antigen. Here are some commonly used methods for evaluating the binding activity of antibody drugs:

• • Peptide Sequence Determination by MS-MS

  Peptide sequence determination is a core component of proteomics research, which involves the precise identification of protein or peptide sequences. MS-MS, also known as tandem mass spectrometry, is a powerful technique used to achieve this goal. This article will introduce the basic principles of peptide sequence determination, the working mechanism of MS-MS technology, and its applications in biomedical research.