• Home
  • Biopharmaceutical Research Services
  • Multi-Omics Services
  • Support
  • /assets/images/icon/icon-email-2.png



    Antibody Drug Activity Testing

      Antibody drugs, particularly monoclonal antibodies (mAb), play a critical role in the treatment of many diseases, especially in the treatment of cancer and immunological disorders. To ensure the effectiveness and safety of these antibody drugs, it is necessary to perform activity testing.


      Definition of Antibody Activity

      The activity of an antibody drug usually refers to its ability to bind to the target antigen and how it affects the target in a biological function, such as neutralizing viruses, killing tumor cells, or regulating immune responses.


      Services at Mtoz Biolabs

      1. Binding Activity Testing

      (1) Enzyme-Linked Immunosorbent Assay (ELISA)

      Uses the target antigen coated on microtiter plates to test the binding ability of the antibody drug.


      (2) Surface Plasmon Resonance (SPR)

      Can detect the binding between the antibody and the target molecule in real-time, and determine the rate constants for binding and dissociation.


      2. Biological Functional Activity Testing

      (1) Cell Proliferation Inhibition Assay

      Used to test whether the antibody drug can inhibit the proliferation of target cells.


      (2) Cytotoxicity Assays

      Such as Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Complement-Dependent Cytotoxicity (CDC).


      (3) Neutralization Assays

      For example, for antibodies targeting viral surface proteins, it can be tested whether they can neutralize the virus and prevent it from infecting cells.


      3. Other Activity Testing

      Antibodies may also have other biological activities, such as regulating the function of immune cells or affecting cell signal transduction. To comprehensively evaluate the activity of an antibody drug, various different experiments may need to be performed.


      To ensure the safety and effectiveness of antibody drugs in clinical applications, activity testing is usually performed multiple times at different stages of development, from early research and screening to later production and quality control.

    Submit Inquiry
    Name *
    Email Address *
    Phone Number
    Inquiry Project
    Project Description *


    How to order?


    Submit Inquiry