Resources
Proteomics Databases
Metabolomics Databases
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• Techniques for Protein Identification Using Mass Spectrometry
Mass spectrometry serves as a powerful analytical technique for identifying and quantifying proteins within complex samples. By measuring the mass-to-charge ratio (m/z) and abundance of peptides or proteins, it enables precise characterization of protein identity and structure. This approach relies on mass spectrometers and involves key steps including sample preparation, peptide separation, ionization, detection, and data analysis. Sample Preparation 1. Protein Extraction Proteins are isolated from......
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The immune peptidome, also referred to as the "Immunopeptidome," encompasses the repertoire of peptides presented by major histocompatibility complex (MHC) molecules on the cell surface. These peptides are derived from the degradation of intracellular proteins and are displayed to facilitate T cell recognition of specific antigens via T cell receptors (TCRs), enabling targeted immune responses. Investigations into the immune peptidome enhance our understanding of how the immune system detects and resp......
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• Advances in Immunopeptidomics
Immunopeptidomics is a scientific discipline dedicated to studying peptide molecules integral to the immune system. This field aims to identify and quantify peptides involved in antigen presentation, immune surveillance, and the orchestration of immune responses. These peptides may be derived from various protein sources, including pathogen-derived proteins, endogenous self-proteins, and non-classical antigens. By investigating these molecules, researchers can deepen their understanding of immune syst......
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MALDI TOF MS is renowned for its high resolution, wide mass range, and rapid analytical capabilities. This technique determines the mass-to-charge ratio (m/z) of ions by measuring their flight time from the ion source to the detector. The unique approach of TOF-MS makes it a powerful tool in fields such as proteomics, metabolomics, and materials science. With ongoing technological advancements, the role of MALDI TOF MS has become increasingly pivotal in both basic research and applied sciences. The ......
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Matrix-assisted laser desorption/ionization time-of-flight (MALDI TOF mass spectrometry) is widely used in proteomics, metabolomics, and other molecular analysis fields. Due to its high sensitivity, broad dynamic range, and ability to cover a wide molecular weight range, MALDI TOF mass spectrometry has become an essential tool for the study of biomolecules. Initially developed by Karas and Hillenkamp in 1988, MALDI TOF mass spectrometry rapidly became a key component of modern mass spectrometry. It ex......
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• Analytical Chemistry Mass Spectrometry
Analytical chemistry mass spectrometry is a vital tool in chemical analysis, used for the separation, identification, and quantification of compounds. This technique relies on the mass analysis of ions, measuring their mass-to-charge ratio (m/z) to extract information about molecular mass and structure. Due to its exceptional sensitivity and specificity, analytical chemistry mass spectrometry is widely applied across fields such as chemistry, biochemistry, and drug development. The fundamental princ......
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• Molecular Weight from Mass Spec
Molecular weight from mass spec is an analytical technique based on mass spectrometry that precisely measures molecular mass. With its high sensitivity, resolution, and broad applicability, it has become an essential tool in modern life sciences and chemical research. This method is widely used in proteomics, drug development, biochemical analysis, and materials science, providing key insights into molecular structure, properties, and functions by analyzing mass characteristics. Principle of Molecul......
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• Intact Protein Quantification
Intact protein quantification is a technique used to analyze the content of intact protein molecules. This method directly quantifies proteins without the need for pre-treatment such as degradation or cleavage, making it especially valuable in proteomics research. By preserving the natural state of proteins, intact protein quantification retains important information, such as post-translational modifications, and offers unique insights for biomarker discovery, drug development, and the study of biolog......
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Mass determination is a high-precision analytical technique based on mass spectrometry, used to measure the mass of molecules or ions. As a crucial tool in modern science and technology, it is extensively applied across fields such as chemistry, biology, pharmacology, and materials science, offering essential support in exploring the molecular and atomic scale of the world. At the core of mass determination is the measurement of the mass-to-charge ratio (m/z) of charged ions using a mass spectromete......
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• Mass Spectrometry Molecular Weight
Mass spectrometry molecular weight determination is a technique used to determine the molecular weight of a molecule or ion by measuring its mass. This method is widely applied in fields such as biological sciences, chemistry, and materials science, where it aids researchers in determining the molecular weight of biomolecules and inferring their molecular structures. The technique relies on the use of a mass spectrometer, a highly sensitive and complex instrument capable of quickly and accurately iden......
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