Resources

Proteomics Databases



Metabolomics Databases

• • Antibody Drug Discovery

  Antibody drug discovery refers to the process of researching and developing novel antibodies for the treatment of various diseases. Antibodies are proteins produced by B cells that specifically bind to distinct antigens, neutralizing pathogens or marking them for immune system recognition. The primary goal of antibody drug discovery is to harness the specificity and high affinity of antibodies to develop drugs capable of precisely targeting diseased cells or pathogens. Compared to traditional small-m......

• • Small Molecule Drug Discovery

  Small molecule drug discovery refers to the process of identifying, optimizing, and developing small molecules with therapeutic potential using scientific methods and technologies. Small molecules typically have a low molecular weight (usually less than 900 Daltons), which allows them to easily penetrate cell membranes and bind to intracellular targets, thereby exerting their therapeutic effects. The process of small molecule drug discovery generally involves several stages, including target identifi......

• • Isotope Labeling

  Isotope Labeling is a powerful technique for introducing stable isotopes into biomolecules, enabling the investigation of dynamic changes and interactions in proteins, metabolites, and other biological molecules. In proteomics, isotope labeling is widely employed to quantify protein expression, analyze post-translational modifications, and trace metabolic pathways. By labeling proteins in distinct samples (e.g., treatment and control groups), this method allows for precise differentiation and quantif......

• • Single-Cell Metabolomics

  Single cell metabolomics refers to a scientific discipline that employs highly sensitive analytical techniques to investigate the metabolite composition and dynamic changes within individual cells. Unlike traditional metabolomics, which typically analyzes the average metabolic profile of a cell population, single cell metabolomics focuses on the metabolic state of individual cells. This approach enables a more precise understanding of cellular metabolic activity, reveals heterogeneity among cells, an......

• • PROTAC

  PROTAC (Proteolysis-targeting chimeras) is an innovative drug development strategy that uses the cell’s natural proteasomal degradation mechanism to selectively degrade target proteins, as opposed to traditional inhibition methods. This strategy overcomes the limitations of small molecule inhibitors, which are often restricted to targeting active sites and have difficulty addressing non-catalytic regions, thus offering a new approach for targeting "undruggable" proteins. The mechanism of PROTAC actio......

• • Accurate Mass Spectrometry

  Accurate mass spectrometry is a high-resolution and high-mass-accuracy technique used for precise molecular mass measurement and in-depth analysis of complex sample components. The core of accurate mass spectrometry is based on high resolution and mass accuracy, achieved with advanced mass analyzers like Fourier transform ion cyclotron resonance mass spectrometers (FT-ICR MS) and Orbitrap mass spectrometers. Mass resolution refers to the ability to distinguish ions with similar masses, while mass acc......

• • Bulk RNA Sequencing

  Bulk RNA sequencing is a technique that utilizes high-throughput sequencing technology to analyze the expression levels of all RNA molecules within a sample. Compared to traditional gene expression analysis methods, such as microarrays, bulk RNA sequencing offers superior sensitivity, resolution, and dynamic range. This approach allows for comprehensive capture of transcriptomic data, including both coding and non-coding RNA expression, gene fusions, alternative splicing events, and mutation analysis......

• • Cell Sequencing

  Cell sequencing is a technology that analyzes the genome, transcriptome, and epigenome of individual or groups of cells using high-throughput sequencing techniques. It allows for the investigation of gene expression, genetic variation, and epigenetic regulation at the single-cell or cell population level, providing detailed insights into cell heterogeneity, developmental trajectories, and functional states. This technology offers a novel perspective for biomedical research, with applications in cance......

• • LC-MS Chromatography

  LC-MS Chromatography is a modern analytical technique that combines liquid chromatography (LC) with mass spectrometry (MS). This approach leverages the unique advantages of both methods and has become an indispensable tool in life sciences, environmental analysis, drug research, and food safety. The liquid chromatography component primarily separates components in complex samples, while mass spectrometry provides high-resolution and high-sensitivity data by analyzing molecular mass and structure. The......

• • Single Nucleus RNA Sequencing

  Single nucleus RNA sequencing is a technique used to analyze RNA expression profiles within individual cell nuclei. It is particularly effective for samples where isolating intact cells is challenging, such as brain tissue rich in lipids. This technology allows researchers to obtain gene expression data at the single-cell level, which is critical for understanding complex biological processes, including development, disease progression, and cell differentiation. Compared to traditional RNA sequencing......