Resources
Proteomics Databases
Metabolomics Databases
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• Gas Chromatography Mass Spectrometry
Gas chromatography mass spectrometry (GC-MS) is a critical analytical tool widely applied in fields such as chemistry, environmental science, biotechnology, and food safety. Its core principle combines gas chromatography with mass spectrometry to separate the components of a sample and subsequently identify and quantify these components. During the gas chromatography process, the sample is vaporized at high temperatures and carried by an inert carrier gas into the chromatographic column, where substa......
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ICP mass spectrometry is an essential analytical tool extensively used across multiple disciplines, including geochemistry, environmental science, biomedical research, and materials science. The technology combines inductively coupled plasma (ICP) as the ionization source with mass spectrometry for elemental analysis. The process involves ionizing the elements in a sample, followed by their analysis and detection by a mass spectrometer. ICP mass spectrometry offers high sensitivity, a broad dynamic r......
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Vaccine discovery refers to the process of identifying, developing, and producing biologic agents that enhance the immune system's ability to defend against specific pathogens through scientific research and experimentation. The central role of vaccines is to stimulate the immune system to generate an immune response against a specific pathogen by simulating an infection, without causing actual infection. This process typically involves pathogen antigen screening, validation of vaccine immunogenicity......
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• Liquid Chromatography Mass Spectrometry
Liquid chromatography mass spectrometry (LC-MS) is an analytical technique that combines the capabilities of liquid chromatography and mass spectrometry. Liquid chromatography is employed to separate the components of a mixture, while mass spectrometry is utilized to detect and identify these separated components. The separation process in liquid chromatography relies on the differences in distribution coefficients of various compounds between the stationary phase and the mobile phase. Following sepa......
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• Receptor-Ligand Binding Assay
Receptor-ligand binding assays are among the core techniques for studying molecular interactions and play a crucial role in life sciences and drug development. The binding of receptors and ligands underpins many biological processes, such as cellular signal transduction, metabolic regulation, and immune responses. Receptors can be proteins located on the cell surface or within the cell, while ligands may include small molecules, peptides, nucleic acids, antibodies, or other proteins. By investigating ......
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Vaccine Development encompasses the entire process from initial antigen discovery to final clinical trials and regulatory approval. Vaccines are designed to prevent infectious diseases by stimulating the immune system to produce specific antibodies, providing protection against future infections. The core of vaccine development lies in identifying and validating antigens capable of inducing effective immune responses. With advancements in proteomics, genomics, and bioinformatics, these technologies ar......
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Functional proteomics is a scientific discipline dedicated to studying protein functions within cells and organisms, focusing on elucidating their biological roles and dynamic changes under specific conditions. By integrating proteomics technologies with functional analyses, this field investigates protein roles in both physiological and pathological processes, providing valuable insights into life sciences. Unlike traditional proteomics, which primarily emphasizes protein identification and quantif......
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• Affinity Purification-Mass Spectrometry
Affinity Purification-Mass Spectrometry (AP-MS) is an integrated method that combines specific protein separation techniques with high-sensitivity molecular detection, widely applied in proteomics research. The principle of this technique involves selectively isolating target proteins and their associated molecules from complex biological samples through affinity purification, followed by identification and quantification using mass spectrometry. Affinity purification relies on high-specificity inte......
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• Competitive Ligand Binding Assay
Competitive ligand binding assay is an experimental technique used to elucidate the binding mechanisms and biological functions of small molecules, drugs, or other ligands by analyzing their competition with biomacromolecules such as proteins, DNA, or RNA. This method is integral to drug discovery, target identification, and mechanistic studies, allowing researchers to characterize ligand binding properties, pinpoint critical binding sites, and refine the activity of lead compounds. The core principle......
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Affinity purification-mass spectrometry (AP-MS) integrates affinity purification techniques with mass spectrometry to investigate molecular interactions, the composition of protein complexes, and the dynamic behavior of functional biomolecules. This method leverages the specific binding properties of target molecules, such as proteins, nucleic acids, or small molecules, to isolate them from complex biological samples while simultaneously capturing associated interacting molecules. Subsequent identific......
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