PRM-Targeted Proteomics Technology
Targeted proteomics, especially Parallel Reaction Monitoring (PRM), is a highly precise mass spectrometry method used for quantifying specific protein expression levels. In contrast to traditional proteomics methods, PRM allows for more precise quantification of specific peptides and proteins by precisely controlling mass spectrometer conditions, thereby increasing selectivity and sensitivity.
The fundamental principle of PRM involves initially selecting peptides using a mass spectrometer, followed by simultaneous monitoring of multiple fragment ions from these preselected peptides in parallel reaction monitoring mode. This approach ensures specific detection of target proteins and enhances the accuracy and reproducibility of the analysis. PRM technology is widely applied in proteomics research, including but not limited to:
1. Discovery and Validation of Disease Biomarkers
By quantifying specific protein expression levels, PRM aids in identifying disease-associated biomarkers.
2. Investigation of Protein Interactions
It enables the analysis of protein complex composition, shedding light on protein interactions.
3. Elucidation of Drug Mechanisms
PRM monitors protein expression changes post-drug treatment to understand drug mechanisms.
4. Personalized Medicine
It supports tailoring treatment plans based on individual protein expression differences.
MtoZ Biolabs, an integrated chromatography and mass spectrometry (MS) services provider.
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