Integrated Neuropeptidomics Analysis Service

Neuropeptidomics is a branch of omics research focused on studying neuropeptides, aiming to systematically analyze their expression patterns, functions, and modification states. It helps reveal the dynamic changes and pathological mechanisms of the nervous system. With advancements in mass spectrometry, neuropeptidomics has gained wide applications, enabling precise detection of low-abundance neuropeptides and their modified forms, providing robust data support for neuroscience and drug development.

 



Secher, A. et al. Nat Commun. 2016.

Figure 1. Analytical Framework for Analysis of Endogenous Peptides

 

MtoZ Biolabs, a global leader in mass spectrometry-based proteomics outsourcing services, is dedicated to providing efficient and precise mass spectrometry analysis solutions for researchers. By integrating multiple advanced technology platforms, we have launched the Integrated Neuropeptidomics Analysis Service designed to offer comprehensive neuropeptide analysis for neuroscience research. This service supports in-depth exploration of neurodegenerative disease mechanisms, neural function studies, and drug screening, helping researchers uncover the complexities of the nervous system and advancing both basic research and clinical applications.

 

Services at MtoZ Biolabs

Our integrated neuropeptidomics analysis service includes, but is not limited to:

1. Neuropeptide Identification and Quantification: Using high-resolution mass spectrometry to identify and quantify neuropeptides in complex samples, including Targeted Mass Spectrometry-Based Quantitative Neuropeptidomics and Untargeted Mass Spectrometry-Based Quantitative Neuropeptidomics analysis, accurately detecting changes in their abundance.

2. Post-translational Modification Analysis: Exploring neuropeptide post-translational modifications, such as phosphorylation and acetylation, using mass spectrometry, to help elucidate their role in neural signaling pathways.

3. Single-Cell Neuropeptidomics Analysis: Deeply investigating the dynamic changes of neuropeptides at the single-cell level.

 

Analysis Workflow

1. Sample Preparation and Extraction: Neuropeptides are extracted from biological samples such as brain tissue, cerebrospinal fluid, or blood. Standard operating procedures are followed to ensure sample representativeness and quality.

 

2. Mass Spectrometry Analysis: Neuropeptides are separated and analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS), combined with Data Independent Acquisition (DIA) technology to enhance accuracy and sensitivity.

 

3. Data Analysis: The data is processed using specialized software and combined with bioinformatics tools to analyze neuropeptide types, abundances, and post-translational modifications.

 

4. Report Generation: Detailed reports are generated based on the analysis results, including neuropeptide quantification data, modification states, and related signaling pathways, providing scientific support for researchers.

 

Service Advantages

1. High Resolution and Sensitivity

Our LC-MS/MS platforms offer extremely high resolution and sensitivity, enabling precise measurements of low-abundance neuropeptides, making them particularly suited for complex biological samples. 

 

2. Customized Solutions

We offer personalized service plans tailored to clients' specific needs. From neuropeptide quantification to post-translational modification detection, we customize the analysis workflow based on the research direction and sample types, ensuring solutions that meet client requirements.

 

3. Multi-Omics Data Integration

MtoZ Biolabs' integrated neuropeptidomics analysis service extends beyond neuropeptide identification and quantification by integrating data from metabolomics and proteomics. This multi-dimensional data integration provides researchers with a more comprehensive view of the neuropeptide's role in neural biology, uncovering deeper insights into their mechanisms.

 

4. Transparent Pricing

MtoZ Biolabs adheres to the principle of transparent pricing. All services come with a detailed breakdown of costs and a full service plan, without hidden charges, allowing clients to manage their projects flexibly within their budget. We offer phase-based billing and customizable service combinations to ensure cost-effective, clear process management for every client.

 

5. Fast Turnaround

Our integrated neuropeptidomics analysis service maintain high quality while offering an efficient experimental process. We promise quick delivery of experimental data and reports, ensuring clients receive valuable research results in the shortest time, advancing their scientific projects.

 

Applications

1. Neurodegenerative Disease Research

By analyzing neuropeptides, researchers can reveal their changes in neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, uncover new disease biomarkers, and contribute to the advancement of personalized medicine.

 

2. Drug Development

In neuropeptides as drug targets research, we help pharmaceutical teams identify potential neuro-related targets, providing solid scientific data for drug development.

 

3. Neurobiology Basic Research

Combining neuropeptidomics with multi-omics analysis, we explore the roles of neuropeptides in signaling pathways, immune responses, and other biological processes, advancing basic research toward clinical application.

 

FAQs

Q: What is the typical service cycle for the integrated neuropeptidomics analysis service?

A: For standard projects, the typical cycle from sample reception to final report delivery is usually 3 to 6 weeks, depending on the number of samples, the complexity of experiments, and the depth of data analysis. MtoZ Biolabs optimizes workflows to shorten the turnaround time while ensuring data quality. We also offer personalized rush service options if needed.

 

Sample Submission Suggestions

 

Requirement	Details
Sample Types	Neuro tissue, cerebrospinal fluid (CSF), blood, etc.
Sample Volume	At least 200 mg of tissue or 200 µL of liquid per sample.
Sample Condition	Samples should be processed according to specified guidelines and stored appropriately to avoid degradation or contamination.
Storage Conditions	Store samples at -80°C or as per provided instructions to maintain integrity.
Shipping Method	Ship samples on dry ice or with appropriate cold storage to ensure sample stability during transit.

 

If you have any specific questions or uncertainties regarding sample types, quantities, or submission requirements, please feel free to contact our technical staff for guidance.

 

Deliverables

1. Neuropeptide quantification and identification report

2. Post-translational modification analysis data

3. Multi-omics data integration report

4. High-quality raw data files

4. Visualized analytical charts and results

 

MtoZ Biolabs’ integrated neuropeptidomics analysis service not only helps you explore the molecular mechanisms of the nervous system but also provides crucial scientific evidence for the diagnosis and treatment of neurological diseases. Whether you're engaged in basic research or preclinical studies, we offer top-notch service and technical support.

 

If you would like to learn more about our services, please feel free to contact us. Let MtoZ Biolabs be your powerful partner in advancing neuroscience research and innovation!