Histone Phosphorylation in Epigenetic Regulation

Kinases such as Aurora and ATM/ATR install histone phosphorylation; phosphatases reverse it. Marks like H3S10ph and γ-H2AX anchor transcription and repair complexes.

Key takeaways

• H3S10/H3S28 linked to activation.
• γ-H2AX marks DNA double-strand breaks.
• Aurora B drives mitotic H3S10 phosphorylation.
• Combines with acetylation and methylation in histone codes.







Related services

Histone PTM analysis Histone Phosphorylation Analysis Service Histone Phosphorylation Analysis Histone Isolation and Enrichment Service Serine/Threonine Phosphoproteomics Analysis Service

Epigenetic MS services Histone Methylation Analysis Histone Acetylation Analysis Phosphoproteomics Analysis Service Deep Phosphoproteomics Service

FAQ

What is γ-H2AX? H2AX Ser139 phosphorylation recruiting DNA repair factors.

How is it measured? Antibodies or LC-MS/MS with phosphopeptide enrichment.

Conclusion

Histone phosphorylation is a fast epigenetic switch integrated with other histone marks.