Custom Chemical Synthesis Service
Chemical synthesis refers to the process of transforming simple starting materials into structurally defined new compounds through a series of organic or inorganic reactions. It is a core technology in modern drug discovery, functional material development, and life science research. In the new drug development, the targeted construction of active and specific candidate molecules is essential for lead optimization, structure–activity relationship (SAR) studies, and structural modifications.
As a professional CRO, MtoZ Biolabs provides high-quality custom chemical synthesis service to research institutions, pharmaceutical companies, and biotech firms. With our experienced scientific team and diversified synthesis platforms, MtoZ Biolabs is capable of efficiently delivering various types of molecules from milligram to gram scale, supporting early-stage drug development and structural exploration.
Services at MtoZ Biolabs
MtoZ Biolabs’ custom chemical synthesis service covers the entire process—from molecular design and route development to product purification and structural confirmation. Our service portfolio includes, but is not limited to:
3. Custom Molecular Glues Synthesis
4. Custom Unnatural Amino Acids Synthesis
6. Custom Small Molecule Synthesis
To accommodate various molecular construction needs, MtoZ Biolabs offers a broad range of chemical transformations, including classical reactions, modern coupling strategies, and functional group modifications. Common examples include:
1. Substitution and Addition Reactions: e.g., nucleophilic/electrophilic substitution, Michael addition, Diels–Alder reactions, for backbone extension and functionalization.
2. Condensation and Hydrolysis Reactions: including esterification, amidation, hydrazone/Schiff base formation and hydrolysis, for linker and peptide bond construction.
3. Coupling Reactions: e.g., Suzuki, Sonogashira, and Buchwald–Hartwig reactions, for connecting aryl, heterocyclic, or alkyl groups via Pd-catalyzed methods.
4. Oxidation and Reduction Reactions: including alcohol oxidation, carbonyl reduction, and hydrogenation, to control oxidation states and molecular conformation.
5. Cyclization and Heterocycle Formation: such as Fischer indole synthesis, Biginelli reaction, Hantzsch synthesis, for pharmacophore construction.
6. Protecting Group Strategies: proficient in handling Boc, Fmoc, TBDMS, etc., enabling selective protection and deprotection in multi-step synthesis.
7. Bioorthogonal and Click Chemistry: such as CuAAC click reactions and thiol–maleimide conjugation, for probe design, conjugate assembly, and labeling.
Analysis Workflow
Service Advantages
1. Comprehensive Synthesis Capability
MtoZ Biolabs has robust capabilities in organic synthesis, covering diverse chemical structures such as aliphatic chains, aromatics, heterocycles, photoactive groups, and fluorinated compounds. We can synthesize both conventional small molecules and complex structures such as PROTAC linkers, bifunctional compounds, and protected peptide building blocks. Each synthesis is tailored through literature research and technical evaluation to minimize risk and cost.
2. Strict Quality Control
We implement quality checkpoints at every stage—from raw material sourcing to final purification and analysis. Standard deliverables include 1H NMR, LC-MS, and HPLC spectra. Upon request, we also provide 13C NMR, HRMS, or IR data to support stringent drug development requirements.
3. Controlled Timelines and Transparent Progress
Each project begins with an assessment of synthetic complexity and estimated turnaround time. Clients receive regular updates throughout the process. Most standard projects are delivered within 2–5 weeks. For urgent cases, we can arrange prioritized scheduling to meet time-sensitive needs.
4. Flexible Collaboration Models
We support both one-time synthesis projects and long-term collaborations, including structure series synthesis and batch deliveries. Clients may request single compounds or multiple analogs. We also support small-scale compound library construction for SAR screening or discovery programs.
5. Support for Structure Derivatization
Structure–activity relationship (SAR) studies are central to medicinal chemistry. MtoZ Biolabs assists clients in designing and synthesizing analogs derived from a parent structure. This enables systematic evaluation of the effects of structural modifications on activity, stability, or selectivity.
Applications
1. Lead compound synthesis and modification in drug development
2. Pharmacophore exploration and SAR studies
3. Construction of chemical probes and fluorescent tags
4. Development of PROTACs and molecular glue compounds
5. Validation and scale-up of functional or novel molecules
FAQ
Q1: Can you synthesize chiral or stereochemically complex molecules?
Yes, we can evaluate the feasibility of synthesizing molecules with stereocenters or other structural challenges. Please contact our project team with details.
Q2: Do you support batch synthesis or long-term supply?
Yes. We can provide stable, recurring supply plans and multi-batch deliveries, ideal for SAR validation or screening projects.
Sample Submission Suggestions
1. Structure Information: 2D structure, SMILES, or CAS number.
2. Purity and Quantity Requirements: e.g., >95% HPLC purity, target delivery amount.
3. Special Reaction Considerations: light sensitivity, moisture sensitivity, exothermicity, etc.
4. Intended Use: e.g., in vitro screening or SAR study. This helps us evaluate complexity and route.
Deliverables
1. Synthesized compound (delivered per agreed specifications and purity)
2. Structural confirmation data (1H NMR, LC-MS, HPLC)
3. Certificate of Analysis (COA)
4. Safety Data Sheet (upon request)
5. Synthetic summary report (if applicable)
In drug discovery, molecular construction, or chemical biology, reliable custom synthesis accelerates research success. With a professional team and standardized platform, MtoZ Biolabs provides flexible, efficient, and well-controlled custom chemical synthesis service tailored to your project needs.
Contact us today for a consultation or quotation, and let MtoZ Biolabs be your trusted synthesis partner.
How to order?
