Custom Unnatural Amino Acids Synthesis Service

Unnatural amino acids (UAAs) are amino acids synthesized through chemical or enzymatic methods that are rarely found or entirely absent in nature. Compared to natural amino acids, UAAs exhibit greater structural diversity, broader physicochemical properties, and customizable functional modules. These features enable UAAs to expand the protein coding repertoire, serving as essential building blocks for modulating molecular function, probing structure–activity relationships, and developing novel therapeutics. Today, UAAs are widely applied in protein engineering, bioorthogonal labeling, targeted drug design, high-throughput compound library construction, and advanced materials development.

 

To address the increasing demand for structurally complex, high-purity, and functionally customizable UAAs in both research and industrial sectors, MtoZ Biolabs offers comprehensive, high-quality Custom Unnatural Amino Acids Synthesis Service. Backed by a strong foundation in organic chemistry and molecular analysis, we deliver one-stop solutions spanning molecular design to product delivery. As a specialized CRO in custom chemical synthesis, MtoZ Biolabs is committed to supporting clients in drug discovery, protein modification, and synthetic biology with efficient and reliable UAA synthesis.

 

Services at MtoZ Biolabs

Our unnatural amino acids synthesis platform integrates a range of synthetic approaches, including asymmetric catalysis, dynamic kinetic resolution (DKR), modular construction, multicomponent reactions (e.g., Ugi and Passerini), and biocatalysis. These strategies enable us to address challenges in stereoselectivity, functional group compatibility, and the construction of cyclic or quaternary carbon structures. We provide customized synthesis for a wide variety of structures, including:

1. Chiral α- or β-amino acid derivatives

2. Functionalized UAAs containing azides, alkynes, phosphates, fluorescent tags, etc.

3. Cyclic, bridged, or rigid scaffolds

4. Building blocks for bioorthogonal reactions, site-specific labeling, or molecular probes

5. Unnatural amino acid cores for medicinal chemistry and drug optimization

 

Our custom unnatural amino acids synthesis service spans milligram-scale exploratory synthesis to gram- and kilogram-scale production, meeting needs from early-stage screening to applied research. Clients may submit a target molecular structure or request support for design and synthetic route development.

 

Analysis Workflow

 



 

Service Advantages

1. Diversified Synthetic Platform

We utilize asymmetric catalysis, multicomponent reactions, and biocatalysis to address various structural complexities. Our experience includes the synthesis of UAAs with multiple chiral centers, sensitive functional groups, and constrained ring systems.

 

2. Rigorous Structure Control and Quality Assurance

Each batch undergoes intermediate and final QC using high-resolution MS, NMR, and HPLC to ensure structural integrity and purity. This guarantees reliable delivery of well-characterized products.

 

3. Experienced Technical Team

Our chemists are highly skilled in synthesizing challenging structures, including quaternary carbon centers, guanidine-modified backbones, bridged rings, and multiply substituted chiral centers. We offer insightful guidance on synthetic design and process optimization.

 

4. Flexible Delivery and Controllable Timelines

From milligram-scale research use to kilogram-scale production, our workflow is adaptable to various project phases. Typical turnaround time is 3–6 weeks, with custom timelines available upon complexity assessment.

 

5. Transparent Pricing

We operate on a one-time-charge model. All fees are quoted up front, covering synthesis, purification, characterization, and reporting. There are no hidden or unexpected costs, enabling straightforward budgeting and project planning.

 

 

Applications

1. Site-specific modification in protein structural and functional studies

2. Enhanced stability and optimization of peptide-based therapeutics

3. Construction of labeled or photo-responsive molecular probes

4. SAR exploration through diverse pharmacophore scaffolds

5. Incorporation of high-functionality monomers in material science

 

FAQ

Q1: I only have a structural concept without a synthetic route. Can you help?

Yes. MtoZ Biolabs can work directly from your target structure or conceptual design. Our team will assess the synthetic feasibility—including stereochemistry, functional group compatibility, and overall complexity—and propose suitable synthetic routes. We also offer structural optimization or alternatives if needed.

 

Q2: Do you support multiple stereocenters and sensitive functional groups?

Yes. We have extensive experience with complex UAAs featuring multiple stereocenters, quaternary carbon frameworks, or cyclic constraints. Using asymmetric catalysis and dynamic kinetic resolution, we can precisely control stereochemistry. For sensitive groups like azides, alkynes, and phosphates, we apply optimized protecting groups and tailored reaction conditions to ensure functional integrity and chemical stability.

 

Deliverables

1. Custom synthesized UAA products: Delivered with ≥95% purity by default (customizable upon request)

2. Structural confirmation data: Including ¹H-/¹³C-NMR, HRMS, and optional FTIR or elemental analysis

3. Purity analysis: HPLC by default; UPLC or LC-MS reports available for selected projects

4. Synthetic route summary: Overview of key steps, reaction strategies, and optimization notes for internal reference or documentation

5. Raw experimental data (optional): Available upon request to support traceability, publications, or regulatory submissions

 

Unnatural amino acids are critical components in life science research and rational molecule design. With a comprehensive synthetic platform and a well-coordinated project management system, MtoZ Biolabs is dedicated to delivering reliable and efficient Custom Unnatural Amino Acids Synthesis Service. Whether you are conducting fundamental research, lead optimization, or material innovation, MtoZ Biolabs is ready to support your project with expert chemistry and consistent results.

 

For quotes or consultation, please contact us today. We look forward to working with you!