Sulfatides Analysis Service

MtoZ Biolabs provides a comprehensive Sulfatides Analysis Service to enable the precise identification and quantification of sulfatides in biological and clinical samples. Sulfatides, also known as sulfated galactocerebrosides, are negatively charged glycosphingolipids widely distributed in the central nervous system (CNS), peripheral nerves, and other tissues. Structurally, they consist of a ceramide backbone linked to a galactose or glucose residue bearing a sulfate group.

 

Sulfatides are essential for myelin stability, neural conductivity, and immune regulation. Dysregulated sulfatide metabolism has been implicated in multiple diseases, including multiple sclerosis, Alzheimer’s disease, metachromatic leukodystrophy, and certain cancers. Leveraging high-resolution mass spectrometry and advanced lipidomics workflows, MtoZ Biolabs delivers reliable and reproducible sulfatide profiling to support both mechanistic research and clinical translational studies.

 

 

Figure 1. The Structural Formula of a Sulfatide

 

Services at MtoZ Biolabs

1. Sulfatide Species Identification and Classification

Using ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS), we identify and classify sulfatide species, including monohexosyl and dihexosyl ceramide derivatives. Analysis covers variations in fatty acyl chain length, unsaturation, and hydroxylation to reveal detailed molecular composition.

 

2. Quantitative Determination of Sulfatides

Quantification strategies include label-free, isotope-labeled, and isobaric labeling methods. Label-free quantification enables relative comparisons, while isotope-labeled standards provide absolute accuracy. TMT or iTRAQ labeling can be adapted for lipidomics workflows to compare sulfatide levels across multiple samples or conditions.

 

3. Structural Characterization and Isomer Differentiation

High-resolution MS/MS determines sulfate group position, glycosidic linkage, and ceramide structure. Ion mobility and negative-ion mode analyses enhance differentiation of structural and positional isomers.

 

4. Targeted and Untargeted Lipidomics Integration

Both targeted and untargeted lipidomics approaches are available. Targeted quantification uses MRM or PRM for precise measurement of specific sulfatide species, while untargeted analysis provides a global lipidome overview for discovering novel metabolites and pathway changes.

 

5. Customizable Analytical Workflows

MtoZ Biolabs designs flexible workflows for neurological disease research, biomarker identification, drug evaluation, and lipid formulation quality control. All analyses are performed under GLP-compliant standards to ensure reliability and data integrity.

 

Sample Submission Suggestions

 



Note: Provide details on sample collection and handling. If you need further details, our technical support team is happy to assist and provide comprehensive guidance on sample submission.

 

Why Choose MtoZ Biolabs?

✅ Advanced Lipidomics Platform: Equipped with high-resolution LC-MS/MS systems such as Orbitrap and Q-TOF, MtoZ Biolabs ensures sensitive and precise sulfatide analysis across all sample types.

✅ Expert Structural and Quantitative Capabilities: Our team combines expertise in glycosphingolipid chemistry and MS-based quantification, providing both qualitative and quantitative insights with scientific accuracy.

✅ Comprehensive Data Interpretation: From molecular identification to biological significance, we integrate data analysis with pathway and network interpretation to enhance research depth.

✅ Customized Project Design: We offer flexible analytical solutions tailored to research objectives, covering method development, validation, and reporting.

✅ One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.

 

This comprehensive Sulfatides Analysis Service supports studies across neuroscience, oncology, metabolism, and immunology by uncovering disease-associated alterations, elucidating lipid–protein interactions, and revealing potential biomarkers and therapeutic targets. With high-resolution and reproducible results, it bridges mechanistic insight and translational application in both academic and industrial research.

 

At MtoZ Biolabs, our Sulfatides Analysis Service integrates LC-MS/MS, ion mobility spectrometry, and advanced bioinformatics to deliver confident identification and quantitation of sulfatides. Our platform helps researchers decode sphingolipid metabolism, discover clinically relevant lipid signatures, and accelerate the development of lipid-targeted therapeutics. For consultation or collaboration, contact the MtoZ Biolabs Lipidomics Team, your trusted partner in precision lipid analysis.

 

What Could be Included in the Report?

1. Comprehensive Experimental Details

2. Materials, Instruments, and Methods

3. Total Ion Chromatogram & Quality Control Assessment

4. Data Analysis, Preprocessing, and Estimation

5. Bioinformatics Analysis

6. Raw Data Files

 

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