Resources

• Full Sequence Analysis of Recombinant Protein Vaccines by Mass Spectrometry

Recombinant protein vaccines are vaccines prepared using genetic engineering techniques, with the aim of inducing an immune response by expressing and producing specific proteins of the pathogen. These vaccines do not contain the complete active pathogen, but instead select specific proteins or parts of proteins of the pathogen as antigens.

• Mass Spectrometry Exploring Diverse Sites of Histone Epigenetic Modifications

Epigenetic modifications are a genetic mechanism that alters gene expression without changing the genetic sequence. It mainly includes DNA methylation of the genome and modifications of histones. Among them, histone modifications are of particular interest in the field of biology and play a crucial role in the study of many major diseases.

• Neoantigen Screening and Immunotherapy

Cancer has always been a major threat to human health. However, with the continuous advancement of technology, immunotherapy, as an innovative cancer treatment, has gradually shown great potential. Immunotherapy activates the patient's own immune system to actively attack cancer cells, becoming the beacon of hope in leading the new era of cancer treatment. In personalized immunotherapy, the screening technology for neoantigens plays a crucial role.

• Mass Cytometry Markers Revealing Cellular Heterogeneity

Mass cytometry, as an important tool in the field of biopharmaceutical research, has revealed the secrets of cells by accurately measuring protein expression.

• Mass Cytometry Sample Preparation and Analysis Steps

In mass spectrometry flow analysis, sample preparation is the first step of the journey and an important part that affects the subsequent analysis. The following steps are essential in the experimental process.

• How to Optimize Analysis Results of Mass Cytometry Single-Cell Protein Detection?

Entering the smallest unit of the human body - individual cells, exploring the mysteries of their proteins, mass spectrometry flow cytometry has opened a new window for us to explore the world. This technology can detect thousands of proteins from a single cell, allowing us to decipher the life code of each cell.

• Disulfide Proteomics Detection and Mass Spectrometry Techniques

Disulfide bonds play a crucial role in biological systems, as they provide a stable three-dimensional structure to proteins and regulate their functions by connecting two cysteine residues. For example, insulin, a commonly active hormone in the human body, contains disulfide bonds.

• The Significance of Phosphorylation Site Identification by Mass Spectrometry

Protein phosphorylation is an extremely important biological process that is directly associated with many life phenomena. Mass spectrometry technology for identifying phosphorylation sites on proteins is gradually becoming a new direction in disease research.

• Fourier-Transform Infrared Analysis of Antibody Drugs

Antibody drugs are a class of drugs that are artificially synthesized antibodies used to treat diseases by specifically binding to target molecules. Common types of antibody drugs include monoclonal antibodies, artificially synthesized antibody fragments, immunotoxins, and antibody-drug conjugates. Antibody drugs have demonstrated significant efficacy in treating various diseases such as cancer, autoimmune diseases, inflammatory diseases, immune regulation, and ophthalmic diseases.

• Mass Cytometry Analysis of Cell Phenotypes

The world of life is so wonderful, with each organism composed of an astonishing number of cells, and each type of cell having its own unique characteristics and functions. How to observe and understand the heterogeneity, cell phenotypes, and their differences has been a long-standing research direction for biologists. For this purpose, the field of biopharmaceuticals brings us a powerful tool - mass spectrometry flow cytometry technology.