Resources
Proteomics Databases
Metabolomics Databases
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Peptide hormone synthesis refers to the chemical or biological production of bioactive peptide hormones. These hormones are small protein molecules composed of amino acids linked by peptide bonds and play vital roles in regulating physiological processes, including growth, metabolism, immune responses, and reproduction. They act by binding to specific receptors, triggering signaling pathways, and modulating cellular activity and behavior. For example, insulin, a well-known peptide hormone, regulates b......
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• Protein-Protein Interaction Network Analysis
Protein-Protein Interaction Network Analysis is a crucial tool for understanding the complex relationships and functional modules formed by protein interactions within cells. Proteins rarely function in isolation; instead, they form intricate networks through stable or dynamic interactions, collectively regulating cellular processes. These networks are fundamental to biological phenomena such as signal transduction, gene expression, and metabolic regulation, and are tightly associated with disease ons......
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• Sequence-Specific DNA Binding Proteins
Sequence-specific DNA binding proteins are proteins that specifically recognize and bind to defined DNA sequences. These proteins are universally present across all living organisms, from bacteria to humans, and play crucial roles in gene expression regulation, DNA repair, replication, and recombination. Their ability to bind depends on the precise arrangement of DNA sequences, allowing them to finely control gene activation and repression, thereby influencing cellular behavior and growth. LC-MS (Li......
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• Protein-Protein Interaction Analysis
Protein-Protein Interaction analysis is a critical method for investigating the interactions between protein molecules and their functional mechanisms within living organisms. This analysis aims to uncover the relationships between different proteins, including their binding sites, binding affinity, and dynamic interaction processes. These insights help scientists better understand the molecular basis of biological processes. Many essential cellular activities, such as signal transduction, cell cycle ......
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IP mass spectrometry is a powerful technique that integrates immunoprecipitation with mass spectrometry analysis, enabling the study of protein interactions and complex protein networks. In biological research, proteins serve as essential molecules responsible for nearly all cellular functions, and understanding protein-protein interactions is crucial for elucidating their functional mechanisms. Using specific antibodies, IP mass spectrometry isolates target proteins along with their interacting partn......
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• Co-Immunoprecipitation Mass Spectrometry
Co-immunoprecipitation mass spectrometry is a powerful technique used to investigate protein-protein interactions and the composition of protein complexes. Immunoprecipitation utilizes specific antibodies to capture and isolate target proteins along with their interacting partners. The success of this method depends on the specificity and affinity of the antibodies, enabling efficient enrichment of target proteins from complex biological samples. Mass spectrometry, known for its high sensitivity and r......
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Protein-Protein Interaction networks refer to complex networks formed by interactions between proteins, playing a crucial role in regulating biological processes. Within each cell, thousands of proteins do not exist in isolation but assemble through specific interactions to form molecular machines or regulatory networks, collectively driving essential biological functions. These networks consist of nodes (proteins) and edges (interactions between proteins) as their core elements, exhibiting highly dyn......
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Circular dichroism spectrum is a spectroscopic technique widely used to study the optical activity of chiral molecules. Chiral molecules, which cannot be superimposed on their mirror images, are commonly found in biological macromolecules such as proteins and nucleic acids. The circular dichroism spectrum measures the difference in absorption between left-handed and right-handed circularly polarized light (known as circular dichroism), providing valuable information on molecular configuration, conform......
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• Mass Spectrometry Protein Sequencing
Mass spectrometry protein sequencing is a core technology in modern biology, pharmacy, and medical research. It utilizes mass spectrometers to precisely analyze proteins, revealing their molecular structures, amino acid sequences, and modification states. As a powerful analytical tool, mass spectrometry protein sequencing offers several key advantages. Firstly, mass spectrometry has exceptional sensitivity, enabling the detection of extremely low-abundance proteins in complex biological samples. Secon......
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HCP analysis is a technique used to detect and quantify residual host cell proteins in biopharmaceutical production. Host cell proteins are byproducts produced alongside the target recombinant protein during its expression in host cells. The main goal of HCP analysis is to detect and quantify these proteins, ensuring the purity of biopharmaceutical products and reducing potential risks to human health. In particular, HCP contamination in the production of biopharmaceuticals can lead to adverse effects......
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