Protein Symmetric Dimethylation Analysis
- Gene Expression and Chromatin Regulation
- Disease Mechanism Research
- Cell Signaling Pathways
- Drug Development
Protein symmetric dimethylation is a key form of post-translational modification (PTM) that typically occurs on lysine (Lys) or arginine (Arg) residues. In symmetric dimethylation, two methyl groups are attached to the nitrogen atoms of the guanidinium group in arginine. This modification is crucial for regulating gene expression, chromatin remodeling, and signal transduction. It significantly impacts biological processes such as cell differentiation, immune response, and cancer progression. Compared to asymmetric dimethylation, symmetric dimethylation is more closely associated with gene silencing and chromatin condensation, making it a primary focus in the study of epigenetic regulation.
Figure 1. Arginine Symmetric Dimethylation
MtoZ Biolabs, utilizing its advanced mass spectrometry platform, provides comprehensive and accurate Protein Symmetric Dimethylation Analysis services. Through high-resolution mass spectrometry and targeted enrichment strategies, we support researchers in uncovering the roles of symmetric dimethylation in gene regulation, signaling pathways, and disease mechanisms.
Analysis Workflow
Services at MtoZ Biolabs
1. Targeted Protein Symmetric Dimethylation Analysis
MtoZ Biolabs provides Targeted Protein Symmetric Dimethylation Analysis focused on the precise detection and quantification of specific symmetrically dimethylated proteins provided by the client, such as histones H3, H4, or other regulatory proteins of interest. By combining immunoprecipitation (IP) with high-resolution mass spectrometry, we accurately identify symmetric dimethylation sites and quantify modification levels. This targeted service is ideal for exploring how symmetric dimethylation affects gene expression, chromatin remodeling, and signal transduction, supporting detailed studies in epigenetics and disease-related protein regulation.
2. Symmetric Dimethylation Proteomics
For broader investigations, MtoZ Biolabs offers Symmetric Dimethylation Proteomics, which provides a comprehensive proteome-wide analysis of symmetric dimethylation patterns. Leveraging high-throughput LC-MS/MS, this service systematically profiles methylation modifications across diverse biological samples. It enables researchers to uncover large-scale modification trends and identify potential biomarkers, advancing understanding of regulatory networks in epigenetics, oncology, and metabolic research.
Why Choose MtoZ Biolabs?
1. Advance Analysis Platform: MtoZ Biolabs established an advanced protein PTM analysis platform, guaranteeing reliable, fast, and highly accurate analysis service.
2. One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.
3. High-Data-Quality: Deep data coverage with strict data quality control. AI-powered bioinformatics platform integrate PTM proteomics analysis data providing clients with a comprehensive data report.
4. Comprehensive Coverage: We offer quantitative analysis of symmetric dimethylation across multiple proteins, delivering a detailed modification landscape.
5. Customized Service: We provide flexible and tailored experimental designs to meet specific research needs, offering a personalized approach to analysis.
Sample Submission Requirements
For more sample details, please consult our technical team.
Applications
Deliverables
1. Comprehensive Experimental Details
2. Materials, Instruments, and Methods
3. Total Ion Chromatogram & Quality Control Assessment (project-dependent)
4. Data Analysis, Preprocessing, and Estimation (project-dependent)
5. Bioinformatics Analysis
6. Raw Data Files
With our advanced mass spectrometry platform and expertise, MtoZ Biolabs offers precise Protein Symmetric Dimethylation Analysis for accurate detection and quantification. We also provide services for other methylation modifications, including monomethylation, asymmetric dimethylation, trimethylation, and additional PTMs such as propionylation, acetylation, and phosphorylation. We are committed to delivering comprehensive technical support to advance your research. Please contact us for more details.
MtoZ Biolabs, an integrated chromatography and mass spectrometry (MS) services provider.
Related Services
Protein Trimethylation Analysis
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