LC-MS Analysis Service
- Pharmaceutical Development and Quality Control: Analysis of drug components, metabolism studies, impurity identification, and bioavailability assessments.
- Food Safety Testing: Detection of pesticide residues, food additives, and rapid screening for illicit substances.
- Environmental Analysis and Monitoring: Qualitative and quantitative analysis of environmental pollutants such as organic contaminants in water and soil.
- Metabolomics Research: Comprehensive metabolite profiling in biological systems, contributing to disease research and biomarker discovery.
- Clinical and Biomedical Research: Clinical pharmacology studies, diagnostic biomarker analysis, and research on metabolic disorders.
Liquid Chromatography-Mass Spectrometry (LC-MS) integrates the high-efficiency separation capabilities of liquid chromatography with the highly sensitive and specific detection power of mass spectrometry, making it an essential analytical technique in modern science. LC-MS is widely utilized for qualitative analysis, quantitative analysis, and the identification of complex sample components, playing an indispensable role across various fields such as pharmaceutical development, environmental monitoring, food safety, and biomedical research. With continuous technological advancements and rising analytical demands, businesses and research institutions increasingly require sophisticated LC-MS solutions.
Figure 1. The Elements of an LC–MS System
Services at MtoZ Biolabs
MtoZ Biolabs, a professional instrumentation and analytical services provider, leverages advanced equipment, experienced technical teams, and extensive industry expertise to deliver highly efficient, accurate, and reliable LC-MS Analysis Service.
Our LC-MS analysis services aim to address technical challenges such as composition analysis, identification of unknown substances, quantitative analysis of target compounds, and impurity analysis. Utilizing state-of-the-art instruments such as Thermo Scientific Orbitrap and AB Sciex QTRAP series mass spectrometers combined with ultra-performance liquid chromatography (UPLC), MtoZ ensures exceptional sensitivity, resolution, and accuracy in sample analysis.
The LC-MS Analysis Service is widely applicable to the analysis of various sample types, including small-molecule compounds, metabolites, proteins, biological hormones, drugs and their metabolites, food components, organic pollutants, and biomarkers, enabling clients to obtain reliable and reproducible experimental data.
Analysis Workflow
MtoZ Biolabs offers a clear and efficient LC-MS analysis workflow consisting of the following steps:
1. Project Consultation and Design: Clarify analysis objectives based on client requirements and develop detailed analytical strategies.
2. Sample Preparation and Pre-treatment: Receive and verify samples, strictly adhering to standardized pre-treatment procedures to ensure compatibility and reliable results.
3. Instrumental Analysis and Data Acquisition: Samples undergo liquid chromatography separation followed by mass spectrometry detection to obtain high-quality raw data.
4. Data Analysis and Reporting: Employ professional software (e.g., Xcalibur, Analyst, MassLynx) for comprehensive data interpretation, qualitative and quantitative analysis, and preparation of standardized analytical reports.
5. Results Delivery and Technical Support: Provide detailed analytical reports and original data, complemented by ongoing technical consulting and after-sales support.
Service Advantages
The LC-MS analysis service from MtoZ Biolabs offer the following distinct advantages:
1. Advanced Instrumentation: Equipped with leading international LC-MS systems to ensure sensitivity and resolution of data.
2. Experienced Technical Team: Professionals with extensive theoretical knowledge and practical experience, ensuring reliable data quality.
3. Rigorous Quality Control: Strict quality control protocols throughout the analysis process ensure data accuracy and reproducibility.
4. Customized Services: Tailored analytical plans are designed based on the specific needs of each client, providing flexible and efficient solutions.
5. Detailed Professional Reports: Comprehensive and structured analytical reports to support clients in both research and commercial applications.
Applications
LC-MS analytical techniques have broad applications across industries and research fields, notably in:
Case Study
1. A Validated LC–MS/MS Method for Clinical Pharmacokinetics and Presumptive Phase II Metabolic Pathways Following Oral Administration of Andrographis Paniculata Extract
Songvut, P. et al. Sci Rep. 2023.
Figure 2. MS/MS Spectra of Compounds or Tentative Metabolites Detected in Human Urine afer a Single Oral Administration of A. Paniculata Extract
2. LC-MS Characterization and Purity Assessment of a Prototype Bispecific Antibody
Woods, RJ. et al. MAbs. 2013.
Figure 3. Mass Spectra for Homo-A
FAQ
Q1: What are the sample submission requirements?
A: We accept solid, liquid, or biological samples clearly labeled with appropriate safety information. For detailed preparation instructions, please consult our technical team.
Q2: How long does it typically take to receive results?
A: Standard projects usually take 7-10 working days. Complex or special cases might take longer; timelines are specified in project proposals.
Q3: Does the service include raw data?
A: Yes, we provide comprehensive reports including raw spectra, analytical methods, and detailed interpretation processes.
Q4: Which data analysis software is used?
A: Commonly used software includes Xcalibur, Analyst, and MassLynx, selected based on instrument compatibility and analytical needs.
Q5: Can you assist in manuscript preparation?
A: Yes, our team has extensive research experience and can assist in manuscript preparation and review processes.
By choosing MtoZ Biolabs' LC-MS analysis service, clients receive efficient and reliable technical support to advance scientific exploration and business development. For more information, please feel free to contact us.
How to order?
