Glycated Hemoglobin Measurement Service
- Multiple high-resolution analytical methods (HPLC, MS, CE, Immunoassays) for glycated hemoglobin quantification
- High sensitivity, reproducibility, and low detection limits for clinical diagnostics and research
- Customizable testing solutions to support clinical trials, epidemiological studies, and diabetes management
- Expert scientific consultation to tailor assays for unique research or clinical needs
MtoZ Biolabs provides comprehensive Glycated Hemoglobin Measurement Service that offers precise, reliable, and high-throughput analysis of glycated hemoglobin (HbA1c) levels. This service is essential for diabetes management, clinical diagnostics, and metabolic research, providing valuable insights into long-term blood glucose control.
Overview
Glycated hemoglobin (HbA1c) forms when glucose in the bloodstream binds irreversibly to hemoglobin in red blood cells. The HbA1c level is a critical marker for assessing chronic blood glucose levels and is commonly used in the management of diabetes. Elevated HbA1c levels indicate poor blood glucose control and are associated with an increased risk of diabetes-related complications, including cardiovascular disease, neuropathy, and retinopathy.
Unlike traditional blood glucose measurements, which reflect short-term glucose levels, HbA1c provides a long-term view of glucose control, offering clinicians a more comprehensive assessment of a patient’s glycemic status. Accurate HbA1c measurement is vital for monitoring disease progression, evaluating treatment effectiveness, and guiding therapeutic decisions.
Hörber, S. et al. Biotechnol. Adv. 2020.
Figure 1. Schematic Illustration of the Formation of HbA1c
Services at MtoZ Biolabs
MtoZ Biolabs offers a variety of analytical platforms tailored to provide the highest accuracy and reliability in Glycated Hemoglobin Measurement Service. Each method ensures sensitive detection, reliable quantification, and in-depth analysis of glycation patterns.
1. High-Performance Liquid Chromatography (HPLC)
HPLC with cation-exchange columns effectively separates glycated hemoglobin from other hemoglobin variants. This method provides high-resolution analysis and reproducible results, making it suitable for quantitative HbA1c measurement in plasma, whole blood, or other biological matrices.
2. Mass Spectrometry (MS)
Mass spectrometry provides highly sensitive and detailed analysis of HbA1c, enabling the identification of glycation sites and the quantification of glycation levels on hemoglobin. This approach is ideal for research settings, allowing for structural analysis and in-depth glycation studies.
3. Immunoassays
Immunoassay platforms, including the D-100 HbA1c Analyzer and Siemens DCA Vantage Analyzer, use specific antibody-antigen interactions to quantify HbA1c levels rapidly. These platforms are ideal for high-throughput clinical settings, offering high sensitivity and specificity.
4. Capillary Electrophoresis (CE)
Capillary electrophoresis offers a quick, efficient method for separating and quantifying HbA1c in blood samples. The technique uses an electric field to separate hemoglobin variants based on size and charge, providing reliable and rapid results.
Sample Submission Suggestions
MtoZ Biolabs accepts whole blood, plasma, serum, and other biological fluids for Glycated Hemoglobin Measurement Service. Typically, 50-100 µL of whole blood or plasma is sufficient for accurate analysis. Samples should be stored at −20 °C and shipped on dry ice to ensure sample integrity. Provide basic information such as matrix type, estimated concentration, and intended analysis.
For specific sample preparation instructions or any specialized formats, please contact MtoZ Biolabs for a customized sample submission guideline.
Applications
Our Glycated Hemoglobin Measurement Service supports the following primary applications:
Diabetes Management: Accurate HbA1c measurement is essential for monitoring long-term blood glucose control, assessing treatment effectiveness, and adjusting therapeutic strategies.
Cardiovascular Risk Assessment: Elevated HbA1c levels are associated with increased cardiovascular risk, making HbA1c an important marker for cardiovascular disease prediction and management.
Research on Diabetes Complications: Studying the relationship between glycemic control and complications such as neuropathy, retinopathy, and nephropathy, and evaluating interventions to prevent or mitigate these effects.
Pharmacological Research: Monitoring the impact of new drugs or therapeutic interventions on glycemic control and HbA1c levels in clinical trials.
Epidemiological Studies: Using HbA1c as a key biomarker to assess the prevalence of diabetes and related metabolic disorders in different populations, supporting public health strategies.
Why Choose MtoZ Biolabs?
MtoZ Biolabs combines cutting-edge instrumentation with clinical expertise to offer reliable, reproducible, and scientifically rigorous results for glycobiology and clinical diagnostics.
Key Advantages:
With our Glycated Hemoglobin Measurement Service, MtoZ Biolabs provides trusted analytical solutions for diabetes research, clinical diagnostics, and personalized medicine applications.
FAQ
Q1: Why is HbA1c a better indicator than blood glucose measurements for long-term glycemic control?
HbA1c reflects the average blood glucose concentration over the lifespan of red blood cells (approximately 8-12 weeks), providing a more reliable measure of long-term glycemic control compared to single-point blood glucose measurements.
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