What Are the Key Differences Between N-Linked and O-Linked Glycosylation?
N-linked and O-linked glycosylation are the two predominant forms of glycosylation in glycoproteins, both playing essential roles in various biological processes. Their key differences are summarized as follows:
N-Linked Glycosylation
1. This type of glycosylation occurs on the amide nitrogen of asparagine (Asn) residues.
2. It requires a specific consensus sequence, Asn-X-Ser/Thr, where X can be any amino acid except proline.
3. N-linked glycosylation is initiated in the endoplasmic reticulum (ER) and undergoes further processing and maturation in the Golgi apparatus.
O-Linked Glycosylation
1. O-linked glycosylation occurs on the hydroxyl group of serine (Ser) or threonine (Thr) residues.
2. Unlike N-linked glycosylation, it does not require a specific sequence motif.
3. O-linked glycosylation primarily takes place in the Golgi apparatus.
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