Skin Proteomics Solutions
- Single-batch processing of 1000+ samples.
- Project turnaround time reduced by 50%, ideal for large-scale clinical cohort studies.
- Dynamic detection range spanning six orders of magnitude
- Reproducibility rate as high as 90% (exceeding the industry average of 70%), ensuring reliable identification of differential proteins.
- Ph.D.-level technical team offering full-process support, including sample preparation, experimental design, and data interpretation.
- Publication-ready figures and tables generated with one-click workflows.
As the most complex multifunctional organ in the human body, the skin employs intricate protein networks to maintain barrier defense, immune regulation, and injury repair. However, traditional techniques, limited by sensitivity and throughput, struggle to systematically resolve dynamic protein profiles in skin during health and disease.
MtoZ Biolabs leverages internationally leading mass spectrometry platforms and advanced proteomic technologies to deliver high-precision, cost-effective, and clinically relevant skin proteomics solutions, empowering research into dermatological disease mechanisms, biomarker discovery, and translational medicine.
Figure 1. The Workflow of Skin Proteomics Analysis
Service Advantages
1. Ultra-High Throughput
2. High Sensitivity & Reproducibility
3. Interdisciplinary Support Network
Case Study
1. Spatially and Cell-Type Resolved Quantitative Proteomic Atlas of Healthy Human Skin
A study utilized advanced tissue dissection techniques, flow cytometry, and high-resolution proteomics to construct a spatially and cell-type resolved quantitative proteomic atlas of healthy human skin. The research team analyzed proteins across different skin layers and cell types, identifying and quantifying 10,701 proteins, while mapping their spatial distribution and cellular origins. The findings revealed structural proteins, novel cell-type-specific proteins, and immunologically relevant cytokines and chemokines. This study enhances the understanding of skin cell diversity and provides a crucial proteomic resource for basic and translational research.
Dyring-Andersen, B. et al. Nat Commun. 2020.
Figure 2. In-depth MS-based Proteomic Analysis of Skin-associated Cellular Subsets
2. Spatially Resolved Proteomic Map Shows That Extracellular Matrix Regulates Epidermal Growth
This study constructs a hierarchical skin proteome map using spatial quantitative proteomics, integrating decellularization, laser capture microdissection, and mass spectrometry. The research focuses on the basement membrane (BM), a key niche that regulates epidermal stem cell (EpSC) fate through physical and biochemical signaling. By analyzing normal and diseased skin tissues in situ, the study identifies TGFBI, an ECM glycoprotein, as a regulator that enhances EpSC growth and function and promotes wound healing. These findings illuminate how ECM proteins support EpSCs and provide potential insights for clinical treatment of skin ulcers and epidermal dysfunction-related diseases.
Li, J. et al. Nat Commun. 2022.
Figure 3. Quantitative Proteome Profiling of Spatially Distinct Protein Signatures in Normal Human Skin
Applications
1. Skin Cancer Research
2. Inflammatory Skin Disease Mechanism Investigation
3. Skin Regeneration and Wound Healing
Deliverables
1. Raw Mass Spectrometry files.
2. Protein Identification and Quantification Results (includes peptide sequences, coverage, and LFQ intensity values).
3. Differential Expression Analysis: Volcano plots, heatmaps.
4. Functional Enrichment Reports: KEGG pathway maps, Gene Ontology (GO) annotations.
MtoZ Biolabs leverages innovative 4D-DIA technology, exceptional sensitivity, and a Ph.D.-driven support team to convert your samples into breakthrough discoveries! Whether you are exploring disease mechanisms, validating biomarkers, or accelerating therapeutic innovation, our skin proteomics solutions deliver rapid, reliable, and actionable scientific insights.
How to order?
