Resources
Proteomics Databases
Metabolomics Databases
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• Ultra High Throughput Screening
Ultra high throughput screening utilizes automated and miniaturized platforms to rapidly screen extensive compound libraries, identifying potential active molecules, drug targets, or biomarkers. In drug discovery, ultra high throughput screening is widely applied to identify compounds exhibiting biological activity against specific targets, which typically include proteins, enzymes, or other biomolecules closely involved in disease pathogenesis and progression. By screening against these targets, scie......
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Bulk TCR sequencing is a technique employed for analyzing the genes encoding T-cell receptors (TCRs). The TCR is a key molecule located on the surface of T cells, primarily responsible for recognizing and binding antigens derived from foreign pathogens, thereby initiating immune responses. Because each T cell harbors a unique TCR sequence, the immune system can identify and respond to diverse pathogens. Through bulk TCR sequencing, researchers can conduct deep sequencing on large-scale T-cell samples,......
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LC-MS screening is an efficient analytical technique integrating liquid chromatography (LC) with mass spectrometry (MS). Its primary function is to separate and identify various molecules within samples and analyze them according to their mass and chemical characteristics. LC-MS screening plays an important role in proteomics research, as it enables the identification and quantification of proteins in samples and allows researchers to study protein dynamics comprehensively. Through LC-MS screening, sc......
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• HTS (High-Throughput Screening)
HTS (high-throughput screening) aims to rapidly analyze and evaluate the biological activity or characteristics of large numbers of compounds, proteins, or other biomolecules. Central to this method is the use of automated equipment and miniaturization technologies, which enable rapid, systematic analysis of extensive sample sets to identify potentially bioactive compounds, antibodies, or genes. The applications of HTS span a broad range of fields, from drug discovery to fundamental biological researc......
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Epitope mapping methods are bioinformatics tools widely applied across multiple fields, including vaccine design, antibody development, and disease diagnostics. In vaccine design, these methods precisely identify antigenic epitopes on pathogen surfaces, thereby enhancing vaccine immunogenicity. Scientists can develop targeted vaccines by selecting epitopes capable of eliciting the strongest immune responses, thus improving the host's protective immunity against specific pathogens. Epitope mapping meth......
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ICP metal testing (ICP-MS) is an analytical technique employed for the detection and quantitative analysis of metal elements in environmental samples. ICP metal testing utilizes the high-temperature plasma environment to ionize metal elements within samples, facilitating their precise detection. This technique has extensive applications across environmental monitoring, food safety assessments, geological exploration, and biomedical research. In environmental monitoring, ICP metal testing effectively d......
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Host cell proteins (HCPs) are non-target proteins produced by host cells during biopharmaceutical production. These proteins primarily originate from cell lines used to express recombinant proteins or antibody-based therapeutics, such as Escherichia coli (E. coli) or yeast cells. The presence of HCPs in biopharmaceutical products can have several significant implications: 1. Immunogenicity Certain HCPs may elicit immune responses, leading to adverse effects or reduced drug efficacy due to immunogeni......
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To measure protein stability is a critical aspect of research into proteins' structural integrity and functional activity under various conditions. Proteins are fundamental molecules responsible for essential biological processes, and their cellular functions are highly dependent on their structural integrity. In vivo, protein stability directly impacts enzyme catalytic efficiency, signal transduction accuracy, and immune response effectiveness. Thus, to measure protein stability is not only essential......
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• Parallel Reaction Monitoring (PRM): Principles, Workflow, and Applications
Parallel reaction monitoring (PRM) is a targeted quantitative proteomics technique based on high-resolution mass spectrometry. In recent years, it has gained widespread application in functional protein studies, biomarker validation, and targeted quantification within complex biological matrices. Compared to multiple reaction monitoring (MRM), PRM offers significant advantages in specificity, resolution, and interference resistance, making it particularly suited for high-precision quantification of ta......
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STRING proteomics is a computational approach leveraging the STRING database to analyze protein-protein interaction (PPI) networks. In cellular environments, proteins rarely function in isolation; instead, they engage in intricate interaction networks to regulate biological processes. By integrating large-scale experimental data, computational predictions, and bioinformatics methodologies, STRING proteomics systematically characterizes protein interactions, offering insights into functional networks, ......
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