Resources

Proteomics Databases



Metabolomics Databases

• • Application of Circular Dichroism in Protein Analysis

  Circular dichroism (CD) spectroscopy is a spectral technique used to analyze molecular structures, particularly suitable for studying the secondary structures of biomolecules such as proteins, nucleic acids, and peptides. It utilizes the difference in absorption of left-handed (counterclockwise) and right-handed (clockwise) circularly polarized light to obtain information about the structure of molecules.

• • HDX-MS: Unveiling Protein Structure and Dynamics

  Hydrogen Deuterium Exchange Mass Spectrometry (HDX-MS) is an advanced technique that combines hydrogen-deuterium exchange (HDX) and mass spectrometry (MS) for studying the dynamic structure and interactions of proteins and protein complexes. It provides information about protein secondary and tertiary structure, as well as details of protein dynamics, which are crucial for understanding protein function and protein-protein interactions.

• • Overpressure Solutions in Circular Dichroism Experiments

  The phenomenon of overpressure in Circular Dichroism (CD) experiments usually refers to the excessive pressure generated in the sample cell or system. This can lead to damage, leakage, or degradation of the sample cell, affecting the accuracy of the experimental results.

• • Lactoferrin Circular Dichroism Spectroscopy

  Lactoferrin is a naturally occurring protein found in mammalian milk, especially colostrum. It belongs to the transferrin protein family and its main function is to efficiently bind and transport iron ions. In addition, lactoferrin also exhibits a wide range of biological activities, including antimicrobial, antiviral, anti-inflammatory, and immune-regulating effects. These activities make lactoferrin important in the food industry, nutritional supplementation, and medical fields.

• • Significance of Host Cell Protein Residue Detection in Biopharma

  Host protein residual detection is an important quality control step in the biopharmaceutical process. In biopharmaceuticals, cell lines (hosts) are commonly used to produce proteins or other biological products. These cell lines can be bacteria, yeast, mammalian cells, etc. After the production process is completed, the product needs to undergo multiple purification steps to remove non-target impurities, including host cell proteins.

• • ICP-MS Trace Element Detection in Cardiac Tissue

  The heart tissue contains various trace elements such as magnesium (Mg), zinc (Zn), copper (Cu), selenium (Se), iron (Fe), and calcium (Ca), which play key roles in maintaining heart function and overall heart health. For example, Mg plays a role in maintaining normal heart rhythm, helping the myocardium relax, and preventing arrhythmia. It also participates in energy metabolism and electrolyte balance, which are crucial for heart function.

• • Protein Isoelectric Point Analysis in Adipose Tissue via CIEF

  Adipose tissue, as the main energy storage organ in the human body, plays multiple physiological roles including energy storage, hormone secretion, and regulation of overall metabolism. In recent years, with the increasing prevalence of obesity and related metabolic disorders, proteomic analysis of adipose tissue has become a hot research topic.

• • Analysis of Protein Content in Liver Tissue

  The liver, as the largest solid organ in the human body, carries out complex physiological functions. It is primarily involved in blood purification and detoxification, metabolic regulation, protein synthesis, and bile production. Protein plays a crucial role in the functions of the liver. The liver is responsible for synthesizing various plasma proteins (such as albumin, clotting factors, components of the complement system), as well as being involved in the production and metabolism of lipoproteins.

• • Fish Tissue Protein Glycan Profiling Detection

  Fish tissue protein is the main component of fish meat, including various amino acids and proteins, which has important value for human health. These proteins not only determine the nutritional quality of fish meat, but also affect its taste and processing characteristics. The protein-glycan spectrum detection technology of fish tissue can comprehensively evaluate the quality and characteristics of fish meat.

• • Mechanism of 2D-Electrophoresis

  Two-Dimensional Electrophoresis (2-DE) is a widely utilized separation technique in proteomics research. By leveraging the differences in proteins' isoelectric points (pI) and molecular weights, 2-DE achieves high-resolution separation of complex protein mixtures through two sequential, orthogonal electrophoresis processes.