Resources
Proteomics Databases
Metabolomics Databases
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• Biosimilar Antibody Sequencing
Biosimilar antibody sequencing refers to the detailed analysis of the DNA and protein sequences of biosimilar antibodies. As the biopharmaceutical field continues to grow, antibody biologics are becoming increasingly important in treating various diseases. However, due to the high costs of development, complex clinical trials, and lengthy timeframes, the emergence of biosimilars provides a promising solution to reduce treatment costs and improve drug accessibility. The aim of biosimilar antibody seque......
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Whole proteome analysis is a proteomics research approach based on mass spectrometry technology, designed to systematically examine the types, quantities, functions, and interactions of all proteins within biological organisms or cells. Unlike traditional targeted protein analysis, whole proteome analysis offers a comprehensive tool for understanding the functions and mechanisms of biological systems by identifying and quantifying all proteins in complex biological samples. This technique has broad ap......
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• Autoantibody Biomarker Discovery
Autoantibody biomarker discovery is a multifaceted process that integrates various technical approaches, alongside stringent validation and mechanistic studies, to ensure the clinical relevance of the identified biomarkers. Detecting specific autoantibodies in the human body offers a valuable tool for diagnosing numerous diseases. Autoantibodies are produced by the immune system against the body’s own tissues during immune dysfunction. These antibodies serve as hallmark markers of autoimmune diseases,......
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• 4 Steps of Edman Degradation
Edman degradation is a widely used method for determining the amino acid sequence of peptides and proteins. The 4 steps of Edman degradation involve: initial reaction, cyclization, cleavage, and repetitive cycles. In the first step, the N-terminal amino acid reacts with phenylisothiocyanate (PITC), forming a phenylthiocarbamyl derivative. During cyclization, under acidic conditions, a cyclic derivative (thiazolinone) is formed. In the cleavage step, the cyclic product is converted to phenylthiohydanto......
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• Whole Protein Mass Spectrometry
Whole protein mass spectrometry is a mass spectrometry-based high-throughput proteomics technique designed to comprehensively analyze the protein composition, expression levels, post-translational modifications, and interactions within biological samples. In comparison with traditional protein detection techniques such as Western Blot or ELISA, whole protein mass spectrometry offers significant advantages, including unbiased, highly sensitive, and high-resolution analysis. It enables the identificatio......
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Free amino acid analysis is primarily employed to detect and quantify the types and concentrations of free amino acids in various samples. Free amino acids are unbound within organisms and play crucial roles in processes such as protein synthesis, enzyme regulation, and signal transduction. Thus, analyzing free amino acids can illuminate an organism's metabolic state and support fields like disease diagnosis, nutrition research, and genetic engineering. In the food industry, for instance, free amino a......
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Total amino acid analysis involves the comprehensive quantitative and qualitative assessment of all amino acids present in biological or chemical samples. By comparing retention times of sample amino acids to those of standards, the identity of amino acids can be established. A match in retention times indicates the presence of a specific amino acid in the sample. Quantification is achieved through standard curve methodology, where standard curves for each amino acid are constructed. By measuring the ......
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• Antibody De Novo Sequencing: Advances in Mass Spectrometry
Antibody de novo sequencing is the process of determining the amino acid sequence of an antibody purely through the analysis of the antibody protein itself, without relying on known genetic sequence templates. Mass spectrometry is central to this process. Advances in mass spectrometry, such as the ethcd fragmentation mode in eclipse mass spectrometry, enable the differentiation of leucine (Leu) and isoleucine (Ile) through neutral losses of 43Da and 29Da from their side chains, respectively. This deve......
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• Biomarker Discovery and Validation
Biomarker discovery and validation represent key research directions in modern medicine and biology. Biomarkers are indicators detectable through biological techniques, reflecting the presence or change of biological or pathological states. These indicators can include a range of biomolecules such as genes, proteins, and metabolites, as well as physiological and biochemical parameters. The discovery and validation of biomarkers are crucial for early disease diagnosis, therapeutic monitoring, and the d......
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• Protein Mass Spectrometry Service: Precision Protein Analysis
Protein mass spectrometry services are specialized offerings that utilize mass spectrometry technology for the analysis of proteins. This technology, known for its high sensitivity and resolution, enables the precise identification and quantification of proteins. These services are primarily employed to investigate the structure, function, and interactions of proteins. The fundamental principle involves converting protein molecules into charged ions, which are then analyzed based on their mass-to-char......
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