Resources

Proteomics Databases



Metabolomics Databases

• • Comprehensive Insights into Protein Identification Techniques and Future

  Protein is one of the most fundamental components in living organisms and plays a crucial role in understanding their functions and disease mechanisms. The development of protein identification techniques has provided powerful tools for in-depth protein research.

• • In-Depth Analysis of Experimental Steps in Protein Characterization

  Protein is one of the most fundamental functional molecules in organisms, and it is of great significance for understanding the structure and function of biological entities. Protein structure identification is one of the key research areas in the field of biopharmaceuticals.

• • The Principles and Processes of Protein De Novo Sequencing Technology

  De Novo Sequencing is a technique used to determine the amino acid sequence of proteins or peptides solely based on experimental data, without relying on any known protein or nucleic acid databases. This technology is particularly important in the identification of new proteins or modified proteins.   De Novo Sequencing usually utilizes Mass Spectrometry (MS). Proteins or peptides are ionized in the mass spectrometer to produce positive ions.

• • Host Cell Protein (HCP) Detection Methods and Their Principles

  HCP (Host Cell Proteins) refer to protein impurities from the production cells in the process of biological product production. For example, when recombinant proteins are produced using mammalian cells (such as CHO cells), in addition to the target protein, there may be some proteins from the CHO cells themselves in the final product. These HCPs may affect the stability, potency, or safety of the product, so they need to be detected and controlled.

• • FT-IR (Fourier Transform Infrared Spectroscopy) Analysis

  FT-IR (Fourier Transform Infrared Spectroscopy) analysis is a technique widely used for the identification of chemical substances and the study of molecular structures. It is based on the specific absorption of infrared radiation by different chemical bonds and functional groups.   When molecules are irradiated with infrared radiation, they absorb radiation of specific wavelengths, leading to vibrations in the chemical bonds within the molecule.

• • Phosphorylation of Proteins

  Protein phosphorylation is one of the most common and important post-translational modifications in cells. Phosphorylation plays a crucial role in regulating protein activity, subcellular localization, interactions, and stability by adding or removing phosphate groups on specific amino acid residues of proteins.   Basic Process of Phosphorylation The phosphorylation process mainly involves two types of enzymes: protein kinases and protein phosphatases.

• • MtoZ Biolabs: Advanced Post-Translational Modification (PTM) Proteomics Services

  At MtoZ Biolabs, we offer comprehensive proteomic solutions designed to thoroughly analyze PTMs. Our state-of-the-art platform employs advanced mass spectrometry technologies coupled with highly specialized enrichment techniques, providing robust, sensitive, and precise PTM analysis. Our services cover the identification, quantification, and characterization of PTMs, offering valuable insights for academic and pharmaceutical research.

• • MtoZ Biolabs: Comprehensive Proteomics Services

  Proteomics is the large-scale study of proteins, the vital executors of life processes, which are responsible for a range of biological functions, from cellular structure to signal transduction and metabolism. Our proteomics services at MtoZ Biolabs aim to analyze and quantify the entire set of proteins expressed by a cell, tissue, or organism. We provide solutions for identifying proteins, elucidating their structure, post-translational modifications, and interactions, offering deep insights into biologica

• • Detection of Glycosylation Modifications in Proteins

  Glycosylation refers to the attachment of carbohydrate moieties (glycans) to proteins, significantly influencing their structure, stability, and function. There are two main types of glycosylation: N-linked glycosylation, where glycans are attached to the nitrogen atom of asparagine residues, and O-linked glycosylation, where glycans are attached to the oxygen atom of serine or threonine residues.

• • Procedure for Ubiquitin Proteomics Analysis

  Ubiquitin proteomics involves identifying and quantifying ubiquitinated proteins within a biological sample. This comprehensive analysis helps elucidate the dynamics of ubiquitination and its impact on cellular functions. The workflow for ubiquitin proteomics is complex and involves several critical steps, including sample preparation, ubiquitin enrichment, mass spectrometry analysis, and data interpretation.