Resources
Proteomics Databases
Metabolomics Databases
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Antibody protein sequencing is a vital technique for determining the amino acid sequences of antibody molecules. As key components of the immune system, antibodies have structures and functions directly linked to their ability to identify and neutralize foreign pathogens. The diversity and specificity of antibodies are largely dictated by their amino acid sequences. Thus, obtaining detailed sequence information is crucial for advances in biomedical research, drug development, and immunological studies......
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• C-Terminal Sequencing of Proteins
C-terminal sequencing of proteins involves identifying and analyzing the amino acid sequence at the protein's carboxyl-terminus using various chemical or enzymatic methods. In the field of proteomics, determining the C-terminal sequence is crucial as it influences the protein's function, stability, cellular localization, and interactions. Alterations in the C-terminal sequence can lead to various diseases, making it vital for diagnostic and therapeutic purposes. Moreover, C-terminal sequencing of prot......
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• Mass Spectrometry of Proteins and Peptides
Mass spectrometry of proteins and peptides is a powerful technique for identifying and quantifying these biomolecules in complex biological samples. This method is central to proteomics research, offering insights into the complexity and functions of proteins within biological systems. By measuring the mass-to-charge ratio (m/z) of ionized molecules or their fragments, mass spectrometry of proteins and peptides enables high-precision and high-sensitivity structural analysis. Applications of this techn......
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• Mass Spectrometry-Based Chemical Proteomics
Mass spectrometry-based chemical proteomics merges chemical probes, mass spectrometry, and bioinformatics to elucidate the functions, structures, and interactions of proteins within cellular environments. This sophisticated technique offers efficient and precise identification of proteins along with their post-translational modifications. Its applications extend to uncovering protein mechanisms, identifying drug targets, and deciphering signal transduction pathways in intricate biological systems. Suc......
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• Mass Spectrometry-Based Label-Free Quantitative Proteomics
Mass spectrometry-based label-free quantitative proteomics serves as an analytical technique for assessing the absolute and relative abundance of proteins within biological samples. Unlike traditional isotopic or chemical labeling methods, this label-free approach directly quantifies proteins by measuring the signal intensities from mass spectrometry. The foremost advantage of this methodology lies in its ability to bypass complex sample preparation, enabling more rapid and cost-effective handling of ......
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Phosphoprotein analysis, a specialized area within proteomics, focuses on the locations, regulatory mechanisms, and biological functions of phosphorylation within proteins. Phosphorylation, one of the most prevalent post-translational modifications, is controlled by protein kinases and phosphatases. It regulates protein activity, structure, and interactions dynamically by adding or removing phosphate groups at specific amino acid residues, including serine, threonine, and tyrosine. This modification i......
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• Mass Spectrometry of Amino Acids
Mass spectrometry of amino acids is a scientific technique employed for the qualitative and quantitative analysis of amino acids and their derivatives utilizing mass spectrometry. Amino acids, as fundamental constituents of proteins, play pivotal roles in organisms, including the construction of cellular tissues, involvement in metabolic reactions, and facilitation of signal transduction and immune responses. Due to its high sensitivity, specificity, and throughput, mass spectrometry of amino acids se......
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Protein amino acid analysis is a crucial technique for examining the composition and structure of proteins by determining the types and quantities of amino acids they contain. This analysis offers essential data for understanding protein functions, refining production processes, and developing novel bioproducts. Amino acids, as the fundamental building blocks of proteins, have specific types, proportions, and sequences that dictate protein functionality. This analysis is vital across multiple fields. ......
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PMF proteomics is a protein identification method that utilizes mass spectrometry to analyze the molecular weights of peptide fragments generated by enzymatic digestion of proteins. This process results in a unique "fingerprint" pattern that can be compared against a database for protein identification. PMF proteomics finds applications across various fields. In medical research, PMF is extensively used to identify disease-related proteins, thereby uncovering the molecular mechanisms of diseases. For ......
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• Protein Aggregation Analysis
Protein aggregation analysis is a technique used to study the formation of protein aggregates under specific conditions and their impact on biological functions and the stability of systems. Protein aggregation involves the formation of either insoluble or soluble aggregates through intermolecular interactions due to factors like denaturation, misfolding, or environmental stress. This phenomenon can serve as a normal regulatory process in biological systems or contribute to the pathology of various di......
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