Resources

Proteomics Databases



Metabolomics Databases

• • CD-Based Peptide Secondary Structure Analysis

  In life sciences, the conformational states of peptide molecules critically influence their biological functions, particularly in essential processes such as signal transduction, immune recognition, and drug development. The peptide’s secondary structure, comprising α-helices, β-sheets, and random coils, not only defines its spatial architecture but also plays a central role in molecular interactions. Circular Dichroism (CD) spectroscopy, a rapid and sensitive spectroscopic technique, has become a ......

• • Pros and Cons of 3 Common Protein Structure Analysis Methods

  Proteins, as fundamental molecules driving biological processes, have their three-dimensional structures directly determining their functions. Accurate analysis of protein structure not only facilitates elucidation of biological mechanisms but also provides critical insights for drug discovery and disease mechanism studies. Currently, the principal techniques for protein structure analysis include X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryo-electron microscopy (Cryo-EM).

• • Top 5 Methods for Protein Structure Analysis and Their Applications

  The function of a protein is intrinsically linked to its three-dimensional structure. Protein structure analysis not only facilitates the interpretation of biological behavior but is also extensively utilized in diverse research areas, including drug discovery, antibody engineering, and the elucidation of metabolic pathways. Currently, researchers have access to multiple analytical techniques for analyzing protein structure, each with distinct advantages, limitations, and suitability for specific protein...

• • Protein Primary Structure Characterization Methods

  Proteins are fundamental biomolecules essential for life processes, and their structures are intrinsically linked to their functions. The primary structure of a protein refers to the linear sequence of amino acids, which serves as the foundation for the formation of higher-order structures such as secondary, tertiary, and quaternary conformations. Accurate determination of a protein’s primary structure is critical for elucidating its biological functions, investigating structural alterations, developing....

• • How Single Cell Proteomics Accelerates Precision Medicine

  Precision medicine aims to formulate scientifically informed diagnostic and therapeutic strategies tailored to individual patient characteristics. This approach fundamentally depends on a deep understanding of disease mechanisms and the ability to monitor therapeutic responses dynamically. With the advancement of omics technologies, platforms such as genomic sequencing, transcriptome analysis, and single-cell RNA sequencing have laid the groundwork for precision medicine. However, precision medicine......

• • Single Cell Proteomics Strategies in Immunology Research

  The immune system exhibits a highly sophisticated capacity for dynamic regulation, playing pivotal roles in processes such as host defense, tumor surveillance, autoimmunity, and tissue repair. Emerging evidence indicates that immune cells display substantial functional heterogeneity depending on developmental stages, microenvironmental cues, or external stimuli. In recent years, advances in single-cell technologies have significantly enhanced the resolution at which immunological processes can be studied...

• • How to Efficiently Identify Protein Structures: Technologies and Tools Explained

  The three-dimensional structure of a protein is fundamental for understanding its biological functions, molecular mechanisms, and therapeutic potential. Compared to sequence analysis, protein structure determination provides greater explanatory power in elucidating functional mechanisms, mapping protein interaction networks, and facilitating drug discovery. Consequently, how to identify protein structures effectively has become a central challenge in contemporary life sciences. With advances in both .......

• • Optimized Workflow for Single Cell Proteomics Using Mass Spectrometry

  Single cell proteomics (SCP) represents one of the most innovative technologies in modern life sciences, enabling high-resolution analysis of protein expression and functional dynamics at the individual cell level. Particularly in highly heterogeneous systems such as tumors, the immune system, and stem cell populations, SCP offers a powerful approach to elucidate cell fate decisions, state transitions, and disease progression from a functional standpoint. Within the SCP experimental framework, the .......

• • Methods and Applications of Protein Circular Dichroism (CD) Spectroscopy

  Circular Dichroism (CD) spectroscopy is a chiroptical technique that detects the differential absorption of left- and right-circularly polarized light by chiral molecules. It has been widely employed to investigate protein secondary structure, conformational dynamics, thermal stability, and folding pathways. Owing to its non-destructive nature, high sensitivity, and ease of use, CD spectroscopy has become an essential tool for protein structural characterization. In the fields of life sciences and ......

• • How to Interpret High-Dimensional Data in Single Cell Proteomics

  Single cell proteomics (SCP) is rapidly emerging as a powerful tool for dissecting cellular heterogeneity and the dynamic nature of biological processes. By profiling protein expression at the resolution of individual cells, researchers can gain critical insights into the molecular underpinnings of tissue homeostasis, disease progression, immune responses, and more. However, SCP data are inherently high-dimensional, typically involving the quantification of hundreds to thousands of proteins per cell........