Neuroproteomics Research Solutions
- Data-Independent Acquisition (DIA) for high-throughput, reproducible protein quantification.
- Neural biomarker analysis in CSF and blood for early disease detection.
- Post-translational modification analyses such as phosphoproteomics, glycoproteomics, and ubiquitinomics for studying key regulatory modifications.
- Affinity-based enrichment for low-abundance PTMs in neural proteins.
- Spatial proteomics to map protein expression in specific brain regions.
- Single-cell proteomics for understanding neuronal and glial cell heterogeneity.
- Affinity purification-MS (AP-MS) for large-scale neural protein interaction mapping.
- Crosslinking mass spectrometry (XL-MS) for structural insights into protein complexes.
- Alzheimer’s disease (AD)
- Parkinson’s disease (PD)
- Amyotrophic lateral sclerosis (ALS)
- Huntington’s disease (HD)
- Autism spectrum disorder (ASD)
- Schizophrenia
- Intellectual disabilities
- Stroke
- Traumatic brain injury (TBI)
- Multiple sclerosis (MS)
- Learning and memory disorders
- Epilepsy
- Mood disorders (e.g., depression, bipolar disorder)
- High Throughput: Quantify thousands of proteins in a single run, efficiently processing large datasets.
- High Accuracy: MtoZ Biolabs' Neuroproteomics Research Solutions achieve low variability in large-scale projects, ensuring reliable and consistent results.
- Comprehensive Coverage: Identify nearly all detectable molecules, including low-abundance proteins and peptides.
- Flexible Data Analysis: MtoZ Biolabs' Neuroproteomics Research Solutions offer standard and advanced analysis tailored to your research needs.
- Cost-Effective: Provide high-quality data at a competitive cost, ensuring accessibility for cutting-edge research.
- Sample Types: We accept various sample types, including protein, cells, CSF(fresh frozen), tissues, FFPE slices, etc.
- Storage and Shipping: Samples should be stored at -80℃ and shipped with dry ice.
The nervous system is one of the most complex and dynamic biological systems, with highly specialized cell types and intricate signaling networks. Understanding the proteomic landscape of the brain and neural tissues is essential for decoding molecular mechanisms of brain function, neurological diseases, and neurodevelopmental disorders. Neuroproteomics is the large-scale study of neural proteins, including their expression, post-translational modifications (PTMs), interactions, and functions. By integrating high-resolution mass spectrometry (MS) with advanced bioinformatics, neuroproteomics provides key insights into neurodegenerative diseases, synaptic plasticity, neuroinflammation, and brain development.
Figure 1. Applications of Neuroproteomics Research
Challenges in Neuroproteomics Research
1. Low-Abundance Neural Proteins
Many critical brain proteins are expressed at low levels, requiring high-sensitivity MS detection.
2. Complexity of Post-Translational Modifications (PTMs)
Phosphorylation, glycosylation, ubiquitination, and other PTMs play key roles in brain function but require specialized enrichment and analytical workflows.
3. Sample Heterogeneity
Brain tissues contain diverse cell types, including neurons, glial cells, and immune cells, making cell-type-specific proteomics essential.
4. Limited Availability of Neural Samples
Human brain tissue is often difficult to obtain, requiring the use of cerebrospinal fluid (CSF), plasma, or stem cell-derived neural models for biomarker discovery.
Service at MtoZ Biolabs
MtoZ Biolabs offers cutting-edge Neuroproteomics Research Solutions to support biomedical and clinical research in neuroscience. We utilize advanced mass spectrometry (MS) and bioinformatics to drive neuroproteomics research. Our services include but not limited to:
✔️Targeted Proteomics & Biomarker Discovery
✔️Post-Translational Modification (PTM) Analysis
✔️Spatial & Single-Cell Proteomics
✔️Protein-Protein Interaction (PPI) Networks Analysis
Analysis Workflow
Figure 2. Universal Neuroproteomics Workflow
Applicable Neurological Diseases & Research Areas
The Neuroproteomics Research Solutions at MtoZ Biolabs support research in various neurological and psychiatric disorders, including but not limited below:
1️⃣Neurodegenerative Diseases
2️⃣Neurodevelopmental Disorders
3️⃣Neuroinflammation & Brain Injury
4️⃣Synaptic Function & Plasticity
Service Advantages
Sample Submission Suggestions
*Note: Feel free to contact us if you have any additional sample requirements.
Deliverables
1. Comprehensive Experimental Details
2. Materials, Instruments, and Methods
3. Total Ion Chromatogram & Quality Control Assessment
4. Data Analysis, Preprocessing, and Estimation
5. Bioinformatics Analysis
6. Raw Data Files
At MtoZ Biolabs, we provide state-of-the-art Neuroproteomics Research Solutions, delivering high-quality, reproducible data to advance neuroscience research. Contact us today to discuss how MtoZ Biolabs can support your neuroproteomics research!
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