Metagenomic Sequencing Service
Metagenomic sequencing is a culture-independent approach that enables high-throughput sequencing of all microbial DNA present in an environmental sample. By bypassing traditional cultivation steps, this technique allows for comprehensive characterization of complex microbial communities, including unculturable and low-abundance species.
Utilizing advanced platforms such as Illumina NovaSeq, PacBio Sequel IIe, and Oxford Nanopore, metagenomic sequencing captures complete microbial genetic content. When integrated with high-performance bioinformatics workflows, this approach supports de novo assembly, taxonomic profiling, functional annotation, and metabolic pathway prediction—offering deep insights into microbial diversity, functional capacity, and ecological interactions.
MtoZ Biolabs provides end-to-end Metagenomic Sequencing Service with multi-platform flexibility and customizable analysis depth, serving diverse applications in microbial ecology, agriculture, human health, food safety, and beyond.
Services at MtoZ Biolabs
MtoZ Biolabs offers metagenomic sequencing service that directly sequences total microbial DNA without PCR amplification, preserving true species diversity and abundance. Core services include:
· DNA Extraction & Quality Control
Compatible with fecal, soil, water, and fermentation samples. Includes extraction, purity assessment, and quantification.
· Library Preparation & Shotgun Sequencing
Conducted on Illumina NovaSeq or Nanopore platforms for high-resolution, unbiased metagenomic profiling.
· Host DNA Depletion
Removal of host-derived sequences (e.g., human, animal) to focus exclusively on microbial DNA.
· Data QC & Assembly
Adapter trimming, filtering of low-quality reads, contig assembly, and scaffold generation.
· Taxonomic Classification & Community Structure
Accurate annotation using tools such as Kraken2 and MetaPhlAn to determine species composition and relative abundance.
· Functional Gene & Pathway Annotation
Functional profiling via KEGG, eggNOG, and CARD databases to identify metabolic pathways, virulence genes, and resistance determinants.
· Visualization & Reporting
Generation of interactive plots showing taxonomic profiles, diversity indices, gene function distributions, and summary reports ready for publication.
Gu W, et al. Annu. Rev. Pathol. 2019.
Figure 1. Metagenomic Sequencing Workflow
Why Choose MtoZ Biolabs?
✅ Amplification Bias-Free: Shotgun metagenomics skips PCR amplification to preserve true community structure.
✅ Pan-Domain Coverage: Simultaneously detects bacteria, archaea, fungi, viruses, and microeukaryotes.
✅ Comprehensive Functional Insights: Reveals metabolic capabilities, resistance mechanisms, and mobile genetic elements (MGEs).
✅ Strain-Level Resolution: High-resolution analysis for tracking source strains and evaluating relative abundance.
✅ Rich Visual Outputs: Ready-to-publish charts and figures for species distribution, alpha/beta diversity, and functional gene maps.
✅ Scalable & Customizable: Tailored workflows for academic research, clinical microbiology, environmental surveillance, and industrial R&D.
Applications
What Could be Included in the Report?
1. Raw sequencing files (FASTQ) and quality control metrics
2. Microbial community composition and abundance profiles
3. Alpha and beta diversity analyses with visualizations
4. Functional gene and pathway annotation (KEGG, eggNOG, CARD)
5. Comprehensive, standardized report ready for publication and data reuse
To further support your research needs, MtoZ Biolabs’ Metagenomic Sequencing Service offers high-resolution, reproducible data through the integration of advanced sequencing platforms and robust bioinformatics pipelines. From microbial diversity profiling and resistance gene surveillance to functional pathway reconstruction, our service is designed to adapt to a wide range of scientific goals.
For taxonomy-driven or cost-sensitive projects, we also provide 16S rRNA, ITS, and 18S amplicon sequencing options. Contact MtoZ Biolabs today to customize your Metagenomic Sequencing Service and accelerate your discoveries in microbiome science.
Related Services
16S/18S/ITS Amplicon Sequencing Service
Full-Length 16S/18S/ITS Sequencing Service
How to order?
