Integrative Metagenomics-Metabolomics Analysis

Metagenomics is a critical discipline that analyzes the composition and functionality of microbial communities in environmental samples, revealing microbial diversity and its interactions with the environment. In contrast, metabolomics focuses on the alterations of small-molecule metabolites within organisms, providing a holistic view of cellular metabolic activities. By integrating metagenomic and metabolomic data, researchers can identify strains, genes, and metabolites that exhibit intergroup differences from various perspectives, enabling a thorough analysis of the relationships among specific microbial communities, gene functions, and metabolites. This integration helps pinpoint key factors that influence shifts in microbial metabolic states or functionalities.

 

MtoZ Biolabs offers a combined analysis service of metagenomics and metabolomics that integrates high-throughput sequencing with metabolite analysis technologies. Utilizing a systems biology approach, this service merges data from the two fields to explore the effects of microbial communities on host metabolism, thus providing novel insights into the study of complex biological systems.

 

Analysis Workflow

 



 

Service Advantages

1. Innovative and Comprehensive Research Pathway

This service combines metagenomic and metabolomic analyses to bridge the study of microbial community structure and functional mechanisms.

 

2. Multifaceted Perspective

By mapping microbial gene functions to metabolites, it uncovers key microbial groups that drive changes in environmental phenotypes.

 

3. High Throughput and Sensitivity

The capability to analyze numerous samples simultaneously allows for the identification of low-abundance genes and metabolites, significantly enhancing experimental efficiency.

 

4. Systematic Analytical Approach

Employing systems biology methodologies ensures effective integration and interpretation of multi-level data, yielding comprehensive biological insights.

 

Applications

Agriculture and Forestry: Investigating mechanisms of stress resistance, growth and development processes, and breeding conservation studies.

Animal Husbandry: Studying meat and dairy quality and exploring pathogenic mechanisms.

Basic Medicine and Clinical Diagnosis: Identifying biomarkers, elucidating disease mechanisms, classifying diseases, and facilitating personalized treatments.

Biopharmaceuticals: Understanding mechanisms of drug action, conducting efficacy evaluations, and advancing drug development.

Microbial Research: Examining pathogenic mechanisms, resistance strategies, and pathogen-host interactions.

 

Application Case

Metagenomics and metabolomics of Toddy, an Indian fermented date palm beverage



Das, S. et al. Food Res. Int. 2023.

 

MtoZ Biolabs, an integrated Chromatography and Mass Spectrometry (MS) Services Provider, provides advanced proteomics, metabolomics, and multi-omics analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample consumption. For any inquiries or requirements, please contact us.