Is GalNAc-Associated O-Glycosylation Elevated in Cancer Cells Compared to Normal Cells?
In many cancer cells, O-glycosylation, particularly the pattern associated with N-acetylgalactosamine (GalNAc), is often elevated relative to normal cells. This phenomenon arises because glycosylation processes in cancer cells are frequently dysregulated, with O-glycosylation undergoing pronounced alterations as a key mechanism regulating protein function and cellular behavior. The enhancement of GalNAc-type glycosylation may influence multiple biological properties of cancer cells, such as the promotion of tumor growth, migration, and invasion. Nevertheless, the occurrence and magnitude of this alteration depend on the cancer type and the specific cellular context. Therefore, although increased GalNAc glycosylation has been observed across various cancers, this characteristic is not universally exhibited.
MtoZ Biolabs, an integrated chromatography and mass spectrometry (MS) services provider.
Related Services
How to order?
