GO Functional Annotation and Enrichment Analysis Service

The Gene Ontology (GO) is a database created by the Gene Ontology Consortium to provide a standardized vocabulary for gene and protein functions across species, which evolves with ongoing research. It uses a dynamic controlled vocabulary to describe the roles of genes and proteins within cells, offering a comprehensive description of gene and gene product attributes. The GO database is divided into three main categories: biological process (BP), cellular component (CC), and molecular function (MF), each describing potential molecular functions, cellular locations, and biological processes of gene products. Each node in the GO database, identified by unique names such as “Cell”, “Fibroblast Growth Factor Receptor Binding”, or “Signal Transduction”, and a unique identifier like “GO:nnnnnnn”, is annotated based on protein IDs mapped from the Uniprot database. The proteins are then functionally classified. The number of proteins associated with each GO node in BP, CC, and MF is listed, and statistical graphs of the secondary classification of expressed proteins are provided.

 

Services at MtoZ Biolabs

1. GO Secondary Classification Analysis

2. GO Levels Classification Analysis

3. topGO Protein Enrichment Analysis